SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 433
SER A  43
LEU A 382
LEU A 357
 None
 1.02A 1yajA-4b98A:
undetectable		 1yajA-4b98A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  64
GLY A  66
ASN A 292
ALA A  40
GLY A 293
 None
 1.05A 2pkkA-4b98A:
3.0		 2pkkA-4b98A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 107
PRO A 108
LEU A 111
 None
 0.55A 2po7B-4b98A:
2.3		 2po7B-4b98A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  57
VAL A 261
ARG A 267
 None
PXG  A 470 (-4.0A)
None
 0.88A 3b0wB-4b98A:
undetectable		 3b0wB-4b98A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 107
PRO A 108
LEU A 111
 None
 0.35A 3hcrA-4b98A:
undetectable		 3hcrA-4b98A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 104
ALA A 274
ALA A 299
VAL A 286
ASN A 285
 None
 1.04A 3jb3A-4b98A:
undetectable		 3jb3A-4b98A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 276
GLY A 381
VAL A 239
ASN A 379
GLY A 195
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.28A 3km6A-4b98A:
undetectable		 3km6A-4b98A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 9 TYR A 276
GLY A 381
VAL A 239
ASN A 379
GLY A 195
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.31A 3kmoA-4b98A:
undetectable		 3kmoA-4b98A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 164
GLY A 152
ASN A 169
VAL A 179
GLY A 160
 None
 0.99A 3sglA-4b98A:
undetectable		 3sglA-4b98A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 292
ALA A  65
GLY A  64
THR A 425
 None
 1.19A 4bboC-4b98A:
undetectable		 4bboC-4b98A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 186
GLY A 416
GLY A 417
ASN A 169
GLY A 168
 None
 1.00A 4n09D-4b98A:
3.0		 4n09D-4b98A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 226
ARG A 378
GLY A 233
GLY A 230
 PXG  A 470 (-3.9A)
None
None
None
 0.91A 4rdxA-4b98A:
undetectable		 4rdxA-4b98A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 152
HIS A 154
GLY A 148
GLU A 226
 None
None
None
PXG  A 470 (-3.9A)
 1.11A 4v20A-4b98A:
undetectable		 4v20A-4b98A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 114
PHE A 115
LEU A 163
LEU A 283
ALA A 222
 None
 1.12A 5fctB-4b98A:
undetectable		 5fctB-4b98A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 406
LEU A 444
GLY A 441
GLU A 442
 None
 0.86A 5hhjA-4b98A:
undetectable		 5hhjA-4b98A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 341
THR A 291
ALA A 294
GLY A  64
ALA A  65
 None
 1.04A 5lf3Y-4b98A:
undetectable
5lf3Z-4b98A:
undetectable		 5lf3Y-4b98A:
16.19
5lf3Z-4b98A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  64
THR A  62
ASN A 292
 None
 0.62A 5odiG-4b98A:
undetectable		 5odiG-4b98A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 427
TYR A  54
LEU A 382
SER A  58
 None
 1.07A 6a7pB-4b98A:
undetectable		 6a7pB-4b98A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 285
GLY A 160
GLY A 155
GLU A 122
ILE A 128
 None
None
PXG  A 470 (-3.5A)
None
None
 0.97A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 285
GLY A 160
GLY A 155
ILE A 224
GLU A 122
 None
None
PXG  A 470 (-3.5A)
None
None
 1.05A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 113
ASN A 112
LEU A 111
 None
 0.88A 6f7lB-4b98A:
undetectable		 6f7lB-4b98A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 344
ALA A 341
GLY A 338
LEU A 339
ARG A  69
 None
 1.34A 6nm4B-4b98A:
undetectable		 6nm4B-4b98A:
18.65