SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
MET A 327
LEU A 170
ILE A 251
LEU A 188
 None
 1.03A 1dreA-4b99A:
undetectable		 1dreA-4b99A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 TRP A 226
HIS A 145
LYS A 184
 None
 1.33A 1l7xA-4b99A:
1.0		 1l7xA-4b99A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 TYR A 164
TYR A 161
GLU A 356
PRO A 353
 None
 1.26A 1q13A-4b99A:
undetectable		 1q13A-4b99A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
MET A 327
LEU A 170
ILE A 251
LEU A 188
 None
 1.00A 1rx2A-4b99A:
undetectable		 1rx2A-4b99A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
MET A 327
LEU A 170
ILE A 251
LEU A 188
 None
 1.05A 1rx3A-4b99A:
undetectable		 1rx3A-4b99A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
 None
 1.25A 1sqnA-4b99A:
undetectable		 1sqnA-4b99A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 231
GLN A 241
LEU A 170
VAL A 248
 None
 1.18A 1u72A-4b99A:
undetectable		 1u72A-4b99A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 7 ILE A  61
LYS A  84
LEU A 106
ILE A 114
ASP A 200
 R4L  A1394 (-4.0A)
None
None
None
None
 0.76A 1uwjA-4b99A:
5.5		 1uwjA-4b99A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ALA A  82
ILE A 115
LEU A 137
ASP A 143
LEU A 189
 R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
 0.88A 1yi4A-4b99A:
22.7		 1yi4A-4b99A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 ARG A 304
THR A 311
VAL A 307
 None
 0.97A 2q64A-4b99A:
undetectable		 2q64A-4b99A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 PHE A 130
ILE A 385
PHE A  90
ILE A 117
 None
 0.94A 2qwxA-4b99A:
undetectable
2qwxB-4b99A:
undetectable		 2qwxA-4b99A:
19.80
2qwxB-4b99A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
 None
 1.23A 2w8yB-4b99A:
undetectable		 2w8yB-4b99A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 9 VAL A  69
ALA A  82
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.76A 2xp2A-4b99A:
6.5		 2xp2A-4b99A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.64A 2y7jA-4b99A:
26.6		 2y7jA-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.68A 2y7jB-4b99A:
26.7		 2y7jB-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.67A 2y7jC-4b99A:
26.7		 2y7jC-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.69A 2y7jD-4b99A:
26.7		 2y7jD-4b99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
 None
 1.29A 3d90A-4b99A:
undetectable		 3d90A-4b99A:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  69
ALA A  82
LEU A 106
ILE A 115
HIS A 180
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
None
None
 1.00A 3gp0A-4b99A:
37.6		 3gp0A-4b99A:
43.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A  84
LEU A 139
MET A 140
ILE A 198
 None
R4L  A1394 ( 4.9A)
None
None
 0.87A 3gp0A-4b99A:
37.6		 3gp0A-4b99A:
43.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A  82
GLU A 102
LEU A 106
ILE A 115
LEU A 139
 R4L  A1394 ( 3.7A)
None
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
 0.88A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A  82
LEU A 106
ILE A 115
LEU A 139
ASP A 200
 R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.73A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A  82
LYS A  84
ILE A 115
LEU A 139
ASP A 200
 R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.63A 3hecA-4b99A:
35.9		 3hecA-4b99A:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  69
ALA A  82
LYS A  84
GLU A 102
LEU A 106
ILE A 115
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
None
None
R4L  A1394 (-4.9A)
 0.85A 3hegA-4b99A:
36.5		 3hegA-4b99A:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 HIS A 180
PHE A 363
PHE A 365
 None
 0.72A 3lk0D-4b99A:
undetectable		 3lk0D-4b99A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ILE A 115
ALA A  82
LEU A 137
VAL A 135
ALA A  89
 R4L  A1394 (-4.9A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
None
None
 1.04A 3ozuA-4b99A:
undetectable		 3ozuA-4b99A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
MET A 327
LEU A 170
ILE A 251
LEU A 188
 None
 1.14A 3ql0A-4b99A:
undetectable		 3ql0A-4b99A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 ASP A 119
GLY A  52
VAL A  81
VAL A 136
 None
 0.78A 3ufnB-4b99A:
undetectable		 3ufnB-4b99A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 GLY A  64
GLY A  67
VAL A  69
ALA A  82
LYS A  84
LEU A 189
 None
None
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.5A)
 0.85A 3v5wA-4b99A:
25.7		 3v5wA-4b99A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 LEU A 137
MET A 140
ASP A 143
 R4L  A1394 (-3.9A)
None
R4L  A1394 ( 4.2A)
 0.57A 3v5wA-4b99A:
25.7		 3v5wA-4b99A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 ALA A  82
LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
 R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
 0.74A 3zbfA-4b99A:
23.2		 3zbfA-4b99A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.73A 3zbfA-4b99A:
23.2		 3zbfA-4b99A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 9 ILE A 105
ILE A 114
ILE A 115
MET A 140
ILE A 198
 None
None
R4L  A1394 (-4.9A)
None
None
 0.92A 3zosA-4b99A:
6.7		 3zosA-4b99A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 5 VAL A  69
ILE A 114
MET A 140
ILE A 198
 R4L  A1394 (-4.0A)
None
None
None
 0.55A 4c8bA-4b99A:
22.1		 4c8bA-4b99A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 ALA A  82
LYS A  84
LEU A 106
ILE A 114
HIS A 180
LEU A 189
ASP A 200
 R4L  A1394 ( 3.7A)
None
None
None
None
R4L  A1394 (-4.5A)
None
 0.88A 4c8bB-4b99A:
22.3		 4c8bB-4b99A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 PHE A  90
ILE A  86
PRO A  87
PHE A 130
 None
 1.02A 4fgkA-4b99A:
undetectable		 4fgkA-4b99A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
MET A 327
LEU A 170
ILE A 251
LEU A 188
 None
 1.10A 4gh8A-4b99A:
undetectable		 4gh8A-4b99A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 11 VAL A  69
ALA A  82
LYS A  84
LEU A 137
ASP A 143
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
 0.58A 4iaaA-4b99A:
22.5		 4iaaA-4b99A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		8 / 12 GLY A  64
VAL A  69
ALA A  82
LYS A  84
LEU A 137
LEU A 139
ASP A 143
LEU A 189
 None
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
 0.73A 4mkcA-4b99A:
22.7		 4mkcA-4b99A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		8 / 12 GLY A  64
VAL A  69
LYS A  84
LEU A 137
LEU A 139
ASP A 143
LEU A 189
ASP A 200
 None
R4L  A1394 (-4.0A)
None
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
None
 0.74A 4mkcA-4b99A:
22.7		 4mkcA-4b99A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 PHE A 130
ILE A 385
PHE A  90
ILE A 117
 None
 0.94A 4qogA-4b99A:
undetectable
4qogB-4b99A:
undetectable		 4qogA-4b99A:
19.80
4qogB-4b99A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  69
ALA A  82
LYS A  84
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.70A 4r7iA-4b99A:
20.9		 4r7iA-4b99A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ILE A  61
ALA A  82
LYS A  84
ILE A 115
LEU A 139
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
 0.69A 4rz7A-4b99A:
7.6		 4rz7A-4b99A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ILE A  61
ALA A  82
LYS A  84
LEU A 139
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 ( 4.9A)
R4L  A1394 (-4.5A)
 0.57A 4rz7A-4b99A:
7.6		 4rz7A-4b99A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 9 VAL A  69
LYS A  84
ILE A 105
ILE A 115
LEU A 189
ILE A 198
 R4L  A1394 (-4.0A)
None
None
R4L  A1394 (-4.9A)
R4L  A1394 (-4.5A)
None
 1.10A 4v01B-4b99A:
21.9		 4v01B-4b99A:
25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ALA A  82
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.46A 4xoyA-4b99A:
16.0		 4xoyA-4b99A:
46.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ALA A  82
LEU A 139
MET A 140
LEU A 189
 R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 (-4.5A)
 0.54A 4xp3A-4b99A:
38.7		 4xp3A-4b99A:
46.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 9 VAL A  69
ALA A  82
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.82A 5aaaA-4b99A:
22.6		 5aaaA-4b99A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		8 / 10 VAL A  69
ALA A  82
LYS A  84
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.95A 5aabA-4b99A:
22.2		 5aabA-4b99A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		8 / 10 VAL A  69
ALA A  82
LYS A  84
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.93A 5aacA-4b99A:
22.1		 5aacA-4b99A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 9 ILE A  61
GLY A  62
VAL A  69
ALA A  82
ILE A 115
MET A 140
 R4L  A1394 (-4.0A)
R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
None
 0.81A 5lw1B-4b99A:
35.7		 5lw1B-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 10 GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
 R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.55A 5lw1E-4b99A:
26.9		 5lw1E-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 9 GLY A  62
VAL A  69
ALA A  82
LEU A 139
MET A 140
 R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
 0.42A 5lw1H-4b99A:
35.9		 5lw1H-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 ILE A 377
ALA A 380
ILE A 381
GLU A 384
 None
 0.58A 5mvmA-4b99A:
undetectable
5mvmB-4b99A:
undetectable		 5mvmA-4b99A:
11.29
5mvmB-4b99A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 MET A 327
LEU A 321
ALA A 320
ILE A 251
LEU A 163
 None
 1.38A 6cbzB-4b99A:
undetectable		 6cbzB-4b99A:
11.53