SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 141
ILE A 257
TRP A 258
LEU A 235
LEU A 136
 None
 1.13A 1b02A-4b9aA:
undetectable		 1b02A-4b9aA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 103
LEU A  34
LEU A  64
GLY A 109
ALA A 110
 None
 1.26A 1pxxB-4b9aA:
undetectable		 1pxxB-4b9aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 103
LEU A  34
LEU A  64
GLY A 109
ALA A 110
 None
 1.25A 1pxxD-4b9aA:
undetectable		 1pxxD-4b9aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 101
LEU A  34
VAL A  60
LEU A  15
HIS A 120
 None
None
None
None
SO4  A1305 (-4.2A)
 1.44A 1qabE-4b9aA:
undetectable		 1qabE-4b9aA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  15
LEU A  22
SER A  70
 None
 0.63A 1tlmA-4b9aA:
undetectable		 1tlmA-4b9aA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 214
TYR A  39
PHE A 201
TYR A  67
 SO4  A1312 (-4.6A)
SO4  A1312 ( 4.8A)
None
None
 1.37A 1xqlA-4b9aA:
undetectable
1xqlB-4b9aA:
undetectable		 1xqlA-4b9aA:
22.92
1xqlB-4b9aA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  68
SER A  70
THR A  42
HIS A  43
PHE A  10
 None
 1.39A 2hmaA-4b9aA:
undetectable		 2hmaA-4b9aA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 233
GLN A 122
PRO A 121
 None
SO4  A1305 (-3.5A)
SO4  A1305 (-3.2A)
 1.00A 2qhfA-4b9aA:
undetectable		 2qhfA-4b9aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 288
LEU A 292
ILE A  49
ARG A  52
 None
 1.03A 2rlfB-4b9aA:
undetectable
2rlfC-4b9aA:
undetectable		 2rlfB-4b9aA:
8.97
2rlfC-4b9aA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 280
ILE A 270
LEU A 242
VAL A 128
ILE A 104
 SO4  A1304 (-3.7A)
None
None
None
None
 1.19A 3adsB-4b9aA:
undetectable		 3adsB-4b9aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 106
TYR A  67
ARG A 108
GLY A 109
 None
None
SO4  A1312 (-4.0A)
None
 1.01A 3b9mA-4b9aA:
undetectable		 3b9mA-4b9aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 274
HIS A 106
MET A 275
 SO4  A1308 ( 3.8A)
None
None
 0.80A 3mihA-4b9aA:
undetectable		 3mihA-4b9aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  11
VAL A  26
VAL A  60
LEU A  96
THR A  92
 None
 1.11A 4yhaA-4b9aA:
undetectable		 4yhaA-4b9aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A  11
VAL A  26
VAL A  60
LEU A  96
THR A  92
 None
 1.21A 4yhaC-4b9aA:
undetectable		 4yhaC-4b9aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 207
CYH A 211
PRO A 163
ILE A 167
 None
 1.05A 5ki6A-4b9aA:
2.3		 5ki6A-4b9aA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  35
HIS A  37
ILE A 104
GLY A 105
GLY A 109
 None
 0.83A 5o96C-4b9aA:
undetectable
5o96D-4b9aA:
undetectable		 5o96C-4b9aA:
22.96
5o96D-4b9aA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A  32
LEU A  33
VAL A 128
PHE A 291
LEU A 292
 GOL  A1313 ( 4.7A)
None
None
None
None
 1.41A 6eliA-4b9aA:
undetectable		 6eliA-4b9aA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4b9a PROBABLE EPOXIDE
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   7
GLU A  55
ALA A  54
LEU A 285
LEU A  61
 None
 1.00A 6f6iA-4b9aA:
undetectable
6f6iB-4b9aA:
undetectable		 6f6iA-4b9aA:
12.71
6f6iB-4b9aA:
13.62