SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 GLU A 195
HIS A 201
ASP A  87
 None
None
CK7  A1285 (-4.0A)
 0.87A 1i9gA-4b9dA:
undetectable		 1i9gA-4b9dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		4 / 8 GLU A  68
THR A  24
TYR A   4
ILE A  32
 None
 1.00A 1qvtA-4b9dA:
undetectable		 1qvtA-4b9dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 12 ILE A 258
PHE A 109
ILE A 186
LEU A 238
ILE A 252
 None
 1.12A 1re7B-4b9dA:
undetectable		 1re7B-4b9dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 10 LEU A 116
HIS A 120
LEU A 144
ILE A 134
ALA A 188
 None
CL  A1287 (-4.1A)
None
None
None
 1.10A 2bxeB-4b9dA:
undetectable		 2bxeB-4b9dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 12 GLU A  25
GLU A  68
GLU A   2
ARG A  67
ARG A  28
 None
 1.29A 2cmlC-4b9dA:
undetectable		 2cmlC-4b9dA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 11 ALA A 150
ASN A 133
LEU A  55
VAL A  54
ILE A  63
 None
 1.05A 3jw5A-4b9dA:
undetectable		 3jw5A-4b9dA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 SER A  69
ASP A 146
ASP A 128
 None
 0.58A 3uj7A-4b9dA:
undetectable		 3uj7A-4b9dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		4 / 8 SER A 233
LEU A 234
PHE A 257
TYR A 229
 None
 1.00A 4j7uD-4b9dA:
undetectable		 4j7uD-4b9dA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 12 GLU A  25
GLU A  68
GLU A   2
ARG A  67
ARG A  28
 None
 1.29A 4mwrA-4b9dA:
undetectable		 4mwrA-4b9dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 SER A  69
ASP A 146
ASP A 128
 None
 0.63A 4mwzA-4b9dA:
undetectable		 4mwzA-4b9dA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 LEU A  88
LEU A 136
ARG A  91
 None
 0.67A 6fgcA-4b9dA:
undetectable		 6fgcA-4b9dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 LEU A  88
LEU A 136
ARG A  91
 None
 0.65A 6fgdA-4b9dA:
undetectable		 6fgdA-4b9dA:
21.72