SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 SER A  63
LEU A  99
ILE A  65
ALA A  96
THR A  93
 None
 1.38A 2v0mD-4b9pA:
undetectable		 2v0mD-4b9pA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		6 / 12 LEU A 117
TYR A  48
LEU A  23
ARG A 110
THR A  49
SER A  86
 None
None
None
None
CA  A1167 (-3.6A)
None
 1.48A 3okxB-4b9pA:
undetectable		 3okxB-4b9pA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A  51
SER A 135
ASN A 134
THR A  17
ASN A  13
 CA  A1167 (-2.3A)
CA  A1167 (-2.5A)
None
None
None
 1.38A 4dajC-4b9pA:
0.0		 4dajC-4b9pA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A  42
LEU A  29
VAL A 105
PHE A  92
 None
 1.03A 4lb0B-4b9pA:
undetectable		 4lb0B-4b9pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A   9
VAL A 154
ILE A  90
ILE A 107
VAL A 105
 None
 1.05A 4y0pA-4b9pA:
undetectable		 4y0pA-4b9pA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PRO A  25
ILE A  15
GLN A  24
ALA A 116
ILE A 111
 None
 1.45A 5zovB-4b9pA:
undetectable		 5zovB-4b9pA:
17.03