SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 VAL A 855
VAL A 856
THR A 709
ARG A 854
 None
 1.12A 3bjwA-4b9wA:
undetectable		 3bjwA-4b9wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 VAL A 855
VAL A 856
THR A 709
ARG A 854
 None
 1.13A 3bjwC-4b9wA:
undetectable		 3bjwC-4b9wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		3 / 3 TYR A 718
MET A 717
ILE A 878
 None
 0.90A 4c8bB-4b9wA:
undetectable		 4c8bB-4b9wA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 10 ALA A 844
VAL A 881
GLU A 885
LEU A 882
LEU A 887
 None
 1.27A 4zmeB-4b9wA:
undetectable		 4zmeB-4b9wA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		3 / 3 VAL A 789
GLN A 806
CYH A 763
 None
 0.83A 5icxA-4b9wA:
undetectable
5icxE-4b9wA:
undetectable		 5icxA-4b9wA:
20.88
5icxE-4b9wA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		3 / 3 VAL A 789
GLN A 806
CYH A 763
 None
 0.82A 5icxC-4b9wA:
undetectable
5icxF-4b9wA:
undetectable		 5icxC-4b9wA:
20.88
5icxF-4b9wA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 GLY A 721
GLN A 821
TRP A 823
VAL A 865
 None
 1.45A 5vunA-4b9wA:
undetectable		 5vunA-4b9wA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 4 GLY A 721
GLN A 821
TRP A 823
VAL A 865
 None
 1.42A 5vuoA-4b9wA:
0.0		 5vuoA-4b9wA:
17.30