SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 8 ALA A 136
LEU A 138
LEU A 173
LEU A 121
 None
 0.87A 1dvtA-4basA:
undetectable
1dvtB-4basA:
undetectable		 1dvtA-4basA:
19.70
1dvtB-4basA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 1.00A 2hyyA-4basA:
undetectable		 2hyyA-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.90A 2hyyB-4basA:
undetectable		 2hyyB-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 8 VAL A  57
ILE A  77
TYR A  74
MET A 102
 None
 0.91A 2weyB-4basA:
undetectable		 2weyB-4basA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.92A 3k5vA-4basA:
undetectable		 3k5vA-4basA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.96A 3k5vB-4basA:
undetectable		 3k5vB-4basA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 8 ASP A  85
SER A  18
ASN A  17
GLY A 160
 None
GNP  A1182 (-3.3A)
GNP  A1182 (-3.9A)
GNP  A1182 (-3.7A)
 0.93A 4fo4A-4basA:
undetectable		 4fo4A-4basA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		5 / 12 LEU A 173
GLY A 169
LEU A 142
VAL A 139
ILE A 155
 None
 1.22A 6bxmA-4basA:
2.5		 6bxmA-4basA:
22.32