SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 105
ALA A 101
LEU A 202
SER A 199
 None
 0.77A 1dvtA-4baxA:
undetectable
1dvtB-4baxA:
undetectable		 1dvtA-4baxA:
17.82
1dvtB-4baxA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 7 MET A 245
SER A 258
ALA A 256
ILE A 317
 None
 1.01A 1fxhA-4baxA:
undetectable
1fxhB-4baxA:
undetectable		 1fxhA-4baxA:
20.75
1fxhB-4baxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 8 MET A 245
SER A 258
ALA A 256
ILE A 317
 None
 1.05A 1gm7A-4baxA:
undetectable
1gm7B-4baxA:
undetectable		 1gm7A-4baxA:
20.75
1gm7B-4baxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 GLU A 318
HIS A 237
ASP A 298
 None
 0.77A 1i9gA-4baxA:
undetectable		 1i9gA-4baxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 THR A  19
PRO A  21
THR A  22
 None
 0.87A 1ovfB-4baxA:
undetectable		 1ovfB-4baxA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 4 LEU A 196
ASP A 337
VAL A 330
THR A  98
 None
 1.30A 3cyxB-4baxA:
undetectable		 3cyxB-4baxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 CYH A 340
THR A 341
THR A 338
HIS A 268
LEU A 259
 None
 1.37A 3gwxB-4baxA:
undetectable		 3gwxB-4baxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 GLY A  49
TRP A  15
VAL A  86
 None
 0.68A 3n62B-4baxA:
undetectable		 3n62B-4baxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 GLY A  49
TRP A  15
VAL A  86
 None
 0.66A 3n65B-4baxA:
undetectable		 3n65B-4baxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 GLY A  49
TRP A  15
VAL A  86
 None
 0.66A 3n66B-4baxA:
undetectable		 3n66B-4baxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 237
GLU A 180
ASN A 232
 None
 0.94A 4bupB-4baxA:
undetectable		 4bupB-4baxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 7 ASP A 327
THR A  22
LEU A 202
LEU A  83
 None
 1.11A 4ib4A-4baxA:
undetectable		 4ib4A-4baxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 335
ARG A 321
ILE A 252
ILE A 253
LEU A 343
 None
 1.25A 4j24C-4baxA:
undetectable		 4j24C-4baxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 335
ARG A 321
ILE A 252
ILE A 253
LEU A 343
 None
 1.21A 4j26B-4baxA:
undetectable		 4j26B-4baxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		4 / 8 LEU A  25
TYR A 210
HIS A 163
LEU A 202
 None
NA  A1351 ( 4.1A)
None
None
 0.92A 4l1xA-4baxA:
undetectable		 4l1xA-4baxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 163
ASN A 166
ALA A 170
 None
 0.38A 5n4tB-4baxA:
undetectable		 5n4tB-4baxA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 GLY A  49
TRP A  15
VAL A  86
 None
 0.65A 5vuoB-4baxA:
undetectable		 5vuoB-4baxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 237
GLU A 180
ASN A 232
 None
 0.87A 5wbvA-4baxA:
undetectable		 5wbvA-4baxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4bax GLUTAMINE SYNTHETASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 237
GLU A 180
ASN A 232
 None
 0.87A 5wbvB-4baxA:
undetectable		 5wbvB-4baxA:
22.78