SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		5 / 12 LEU A 490
VAL A 486
LEU A 372
LEU A 376
HIS A 457
 None
 1.22A 1mx1E-4bbkA:
undetectable		 1mx1E-4bbkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		3 / 3 LEU A 490
ARG A 463
ILE A 487
 None
 0.64A 2xn5B-4bbkA:
undetectable		 2xn5B-4bbkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		4 / 6 CYH A 468
LEU A 453
CYH A 423
LEU A 440
 None
 1.16A 5hpuC-4bbkA:
undetectable
5hpuD-4bbkA:
undetectable		 5hpuC-4bbkA:
16.39
5hpuD-4bbkA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		4 / 4 GLU A 424
PRO A 443
ILE A 442
LEU A 441
 None
 0.97A 5m45A-4bbkA:
undetectable		 5m45A-4bbkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		4 / 4 GLU A 424
PRO A 443
ILE A 442
LEU A 441
 None
 1.04A 5m45D-4bbkA:
2.2		 5m45D-4bbkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		4 / 4 GLU A 424
PRO A 443
ILE A 442
LEU A 441
 None
 0.96A 5m45G-4bbkA:
undetectable		 5m45G-4bbkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4bbk FERMITIN FAMILY
HOMOLOG 1
(Mus
musculus) 		4 / 4 GLU A 424
PRO A 443
ILE A 442
LEU A 441
 None
 1.08A 5m45J-4bbkA:
undetectable		 5m45J-4bbkA:
11.55