SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 HIS A  55
HIS A  53
THR A  62
SER A 132
 None
 0.82A 1gtfN-4bc5A:
undetectable
1gtfO-4bc5A:
undetectable		 1gtfN-4bc5A:
9.72
1gtfO-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 11 SER A 259
PHE A 268
SER A 114
LEU A 125
VAL A  69
 None
 1.49A 1q23G-4bc5A:
undetectable		 1q23G-4bc5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		6 / 12 LEU A 449
GLY A 441
ALA A 442
ILE A 412
GLY A 339
ILE A 448
 None
 1.47A 2rkgA-4bc5A:
undetectable		 2rkgA-4bc5A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 LEU A 121
LEU A  72
ASP A  73
ARG A 120
 None
 0.93A 2rlfA-4bc5A:
undetectable
2rlfB-4bc5A:
undetectable		 2rlfA-4bc5A:
6.54
2rlfB-4bc5A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 LEU A 121
LEU A  72
ASP A  73
ARG A 120
 None
 0.95A 2rlfC-4bc5A:
undetectable
2rlfD-4bc5A:
undetectable		 2rlfC-4bc5A:
6.54
2rlfD-4bc5A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 7 ARG A 265
ARG A 120
ILE A  74
TYR A 266
 None
 1.14A 2yfbA-4bc5A:
undetectable		 2yfbA-4bc5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 ARG A 265
ARG A 120
ILE A  74
TYR A 266
 None
 1.20A 2yfbB-4bc5A:
undetectable		 2yfbB-4bc5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 ILE A 463
ASN A  30
VAL A 471
GLY A 472
 None
 0.80A 3em0B-4bc5A:
undetectable		 3em0B-4bc5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 4 ASP A 215
SER A 217
PHE A 321
SER A 284
 None
 1.47A 3i5uA-4bc5A:
0.2		 3i5uA-4bc5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		3 / 3 ASP A 215
PHE A 321
SER A 284
 None
 0.91A 3i5uB-4bc5A:
undetectable		 3i5uB-4bc5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 11 SER A  63
PHE A  39
LEU A  72
ILE A  75
ASP A  14
 None
 1.45A 3ko0C-4bc5A:
undetectable
3ko0D-4bc5A:
undetectable
3ko0E-4bc5A:
undetectable
3ko0F-4bc5A:
undetectable		 3ko0C-4bc5A:
11.78
3ko0D-4bc5A:
11.78
3ko0E-4bc5A:
11.78
3ko0F-4bc5A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 ASP A  14
LEU A  72
ILE A  75
PHE A  39
SER A  63
 None
 1.38A 3ko0G-4bc5A:
undetectable
3ko0H-4bc5A:
undetectable
3ko0I-4bc5A:
undetectable
3ko0J-4bc5A:
undetectable		 3ko0G-4bc5A:
11.78
3ko0H-4bc5A:
11.78
3ko0I-4bc5A:
11.78
3ko0J-4bc5A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 11 SER A  63
PHE A  39
ASP A  14
LEU A  72
ILE A  75
 None
 1.43A 3ko0Q-4bc5A:
undetectable
3ko0R-4bc5A:
undetectable
3ko0S-4bc5A:
undetectable
3ko0T-4bc5A:
undetectable		 3ko0Q-4bc5A:
11.78
3ko0R-4bc5A:
11.78
3ko0S-4bc5A:
11.78
3ko0T-4bc5A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 PHE A 478
LEU A  11
ALA A  91
ALA A 477
 None
 0.97A 3ns1L-4bc5A:
undetectable		 3ns1L-4bc5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		6 / 9 LEU A 449
GLY A 441
ALA A 442
ILE A 412
GLY A 339
ILE A 448
 None
 1.37A 3nu4B-4bc5A:
undetectable		 3nu4B-4bc5A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
THR A 304
ALA A 332
LEU A 426
LEU A 290
 None
 1.13A 3p5nA-4bc5A:
undetectable		 3p5nA-4bc5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
THR A 304
ALA A 332
LEU A 426
LEU A 290
 None
 1.12A 3p5nB-4bc5A:
undetectable		 3p5nB-4bc5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 GLY A 414
ALA A 418
ARG A 391
GLU A 407
ILE A 346
 None
 1.04A 4aztA-4bc5A:
undetectable		 4aztA-4bc5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 ALA A 108
LEU A 125
SER A 209
PHE A 204
VAL A 274
 None
 1.24A 4eckA-4bc5A:
undetectable		 4eckA-4bc5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 4 PRO A  44
LEU A  43
ILE A  74
ARG A 120
 None
 1.30A 4f4dA-4bc5A:
undetectable		 4f4dA-4bc5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		3 / 3 PRO A 248
TYR A 213
GLY A 216
 None
 0.59A 4g2zA-4bc5A:
undetectable		 4g2zA-4bc5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 5 GLN A 223
THR A 163
LEU A 241
LEU A 234
 None
 0.99A 4lvcB-4bc5A:
undetectable		 4lvcB-4bc5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 5 GLN A 223
THR A 172
LEU A 241
LEU A 234
 None
 1.08A 4lvcB-4bc5A:
undetectable		 4lvcB-4bc5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 ARG A 409
ASP A 454
VAL A 297
ALA A 438
 None
 0.91A 4nkxA-4bc5A:
undetectable		 4nkxA-4bc5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 5 ARG A 476
GLY A  94
ALA A  95
GLY A  12
 None
 0.87A 4u9uA-4bc5A:
undetectable		 4u9uA-4bc5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 5 ARG A 476
GLY A  94
ALA A  95
GLY A  12
 None
 0.86A 4u9uB-4bc5A:
undetectable		 4u9uB-4bc5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 GLY A 279
TYR A 475
ALA A 474
GLY A  94
 None
 0.78A 5albL-4bc5A:
undetectable		 5albL-4bc5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 PHE A 306
ALA A 332
HIS A 319
LEU A 334
 None
None
5FX  A1531 ( 4.5A)
None
 1.26A 5dzkg-4bc5A:
undetectable
5dzku-4bc5A:
undetectable		 5dzkg-4bc5A:
17.94
5dzku-4bc5A:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 SER A 132
HIS A  55
HIS A  53
THR A  62
 None
 0.82A 5eezL-4bc5A:
undetectable
5eezV-4bc5A:
undetectable		 5eezL-4bc5A:
9.72
5eezV-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 SER A 132
HIS A  55
HIS A  53
THR A  62
 None
 0.82A 5ef1L-4bc5A:
undetectable
5ef1V-4bc5A:
undetectable		 5ef1L-4bc5A:
9.72
5ef1V-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 8 SER A 132
HIS A  55
HIS A  53
THR A  62
 None
 0.81A 5ef2L-4bc5A:
undetectable
5ef2V-4bc5A:
undetectable		 5ef2L-4bc5A:
9.72
5ef2V-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 6 TRP A  68
GLY A  51
THR A  17
SER A  63
VAL A  52
 None
None
5FX  A1531 ( 4.8A)
None
None
 1.37A 5ewuA-4bc5A:
undetectable		 5ewuA-4bc5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 6 TRP A  68
GLY A  51
SER A  63
VAL A  52
 None
 1.04A 5ewuB-4bc5A:
undetectable		 5ewuB-4bc5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 279
GLY A 472
SER A 473
LEU A  92
 None
 1.12A 5gwxA-4bc5A:
undetectable		 5gwxA-4bc5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 4 GLN A 223
THR A 163
LEU A 241
LEU A 234
 None
 1.01A 5m5kB-4bc5A:
undetectable		 5m5kB-4bc5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 12 LEU A 362
PHE A 416
ARG A 347
GLY A 300
LEU A 299
 None
 1.24A 5ogcB-4bc5A:
undetectable		 5ogcB-4bc5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		6 / 12 LEU A 449
GLY A 441
ALA A 442
ILE A 412
GLY A 339
ILE A 448
 None
 1.49A 5t8hB-4bc5A:
undetectable		 5t8hB-4bc5A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		4 / 7 LEU A  59
ASP A 139
GLN A 175
GLN A 182
 None
 1.28A 6g31D-4bc5A:
undetectable		 6g31D-4bc5A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4bc5 XYLULOSE KINASE
(Homo
sapiens) 		5 / 11 ILE A 436
LEU A 437
THR A 304
LEU A 307
PHE A 306
 None
 1.21A 6hupA-4bc5A:
undetectable
6hupB-4bc5A:
undetectable		 6hupA-4bc5A:
11.36
6hupB-4bc5A:
9.36