SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 8 GLY A 504
ARG A 503
VAL A 465
PHE A 428
None
0.96A 1gsfC-4bc7A:
undetectable
1gsfC-4bc7A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 7 PHE A 581
VAL A 557
GLY A 556
ILE A 548
None
0.72A 1p2yA-4bc7A:
undetectable
1p2yA-4bc7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 8 VAL A 510
TYR A 513
ASP A 100
LEU A 125
None
1.22A 1pk2A-4bc7A:
undetectable
1pk2A-4bc7A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 ASP A 516
LEU A 519
HIS A 617
None
0.63A 1qknA-4bc7A:
undetectable
1qknA-4bc7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 GLY A 327
ASP A 331
ASN A 324
None
0.52A 1vq1A-4bc7A:
undetectable
1vq1A-4bc7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 8 TYR A 571
SER A 319
TYR A 578
HIS A 616
SO4  A1659 (-4.7A)
None
None
FAD  A 999 (-3.9A)
1.37A 2bteA-4bc7A:
undetectable
2bteA-4bc7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 GLY A 492
TYR A 485
ALA A 394
LEU A 468
LEU A 463
None
1.27A 2npnA-4bc7A:
undetectable
2npnA-4bc7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 8 TYR A 571
SER A 319
TYR A 578
HIS A 616
SO4  A1659 (-4.7A)
None
None
FAD  A 999 (-3.9A)
1.29A 2v0gA-4bc7A:
undetectable
2v0gA-4bc7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 ALA A 495
ALA A 394
SER A 464
GLY A 401
ALA A 466
None
1.11A 2vh3A-4bc7A:
undetectable
2vh3A-4bc7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 ALA A 495
SER A 464
GLY A 401
SER A 392
ALA A 466
None
1.31A 2vh3A-4bc7A:
undetectable
2vh3A-4bc7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 ALA A 496
SER A 464
GLY A 401
SER A 392
ALA A 466
None
1.12A 2vh3A-4bc7A:
undetectable
2vh3A-4bc7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 HIS A 361
MET A 365
MET A 336
None
1.33A 2vj1A-4bc7A:
undetectable
2vj1A-4bc7A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 GLU A 301
GLU A 288
TRP A 313
None
1.19A 3hrdA-4bc7A:
undetectable
3hrdE-4bc7A:
undetectable
3hrdF-4bc7A:
undetectable
3hrdA-4bc7A:
20.00
3hrdE-4bc7A:
20.00
3hrdF-4bc7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 LEU A 658
LYS A 624
VAL A 619
GLY A 620
LEU A 639
None
1.44A 3hvtA-4bc7A:
3.9
3hvtA-4bc7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.10A 3kkzA-4bc7A:
undetectable
3kkzA-4bc7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.10A 3kkzB-4bc7A:
undetectable
3kkzB-4bc7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_1
(16S RRNA METHYLASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 4 ASN A  99
ASP A 516
GLU A 526
TRP A  93
None
1.37A 3mteA-4bc7A:
0.0
3mteA-4bc7A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.10A 3sxjA-4bc7A:
undetectable
3sxjA-4bc7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.09A 3sxjB-4bc7A:
undetectable
3sxjB-4bc7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.14A 3t7sB-4bc7A:
undetectable
3t7sB-4bc7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLN A 400
GLY A 401
SER A 392
GLU A 407
ALA A 488
None
1.11A 3t7sD-4bc7A:
undetectable
3t7sD-4bc7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 THR A 283
GLY A 281
GLY A 311
SER A 261
GLN A 262
None
None
FAD  A 999 (-3.4A)
None
None
1.26A 3tkaA-4bc7A:
undetectable
3tkaA-4bc7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 THR A 283
GLY A 281
GLY A 312
SER A 261
GLN A 262
None
None
FAD  A 999 (-3.5A)
None
None
1.23A 3tkaA-4bc7A:
undetectable
3tkaA-4bc7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 HIS A 187
HIS A 189
ILE A 194
None
0.66A 3u52A-4bc7A:
undetectable
3u52C-4bc7A:
undetectable
3u52A-4bc7A:
19.09
3u52C-4bc7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 8 GLY A 327
LYS A 322
TYR A 326
GLU A 301
None
0.88A 3u9hA-4bc7A:
undetectable
3u9hA-4bc7A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 10 PRO A 415
ILE A 408
HIS A 419
LEU A 405
ILE A 418
None
1.25A 4dtaA-4bc7A:
undetectable
4dtaA-4bc7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 9 VAL A 373
VAL A 338
GLU A 376
GLY A 311
SER A 315
FAD  A 999 (-3.8A)
None
None
FAD  A 999 (-3.4A)
FAD  A 999 (-3.1A)
1.08A 4fwdA-4bc7A:
undetectable
4fwdA-4bc7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 LEU A 405
CYH A 404
PHE A 395
PRO A 415
GLY A 391
None
1.40A 4j7xF-4bc7A:
undetectable
4j7xF-4bc7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLY A 493
ALA A 488
LEU A 468
PHE A 395
SER A 464
None
1.01A 4pb1A-4bc7A:
undetectable
4pb1A-4bc7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLY A 493
ALA A 488
LEU A 468
PHE A 395
SER A 464
None
1.11A 4pd5A-4bc7A:
undetectable
4pd5A-4bc7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
5 / 12 GLY A 493
ALA A 488
LEU A 468
PHE A 395
SER A 464
None
1.01A 4pd9A-4bc7A:
undetectable
4pd9A-4bc7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 VAL A 393
TYR A 485
ALA A 488
None
0.53A 4ybnA-4bc7A:
undetectable
4ybnA-4bc7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 6 ARG A 623
GLY A 618
SER A 242
LEU A 622
None
1.23A 5bphD-4bc7A:
undetectable
5bphD-4bc7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 6 TYR A 296
ILE A 379
VAL A 269
ALA A 276
None
0.82A 5cu6A-4bc7A:
undetectable
5cu6A-4bc7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 GLN A 424
THR A 564
ASP A 422
None
0.82A 5k9dA-4bc7A:
undetectable
5k9dA-4bc7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 7 ILE A  83
ILE A  82
THR A 283
ILE A 282
None
0.91A 5murB-4bc7A:
undetectable
5murB-4bc7A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 SER A 319
HIS A 615
TYR A 571
None
None
SO4  A1659 (-4.7A)
0.97A 5y2tA-4bc7A:
undetectable
5y2tA-4bc7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
4 / 5 ALA A 496
SER A 392
GLY A 391
TYR A 485
None
1.27A 5yodB-4bc7A:
undetectable
5yodB-4bc7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia
porcellus)
3 / 3 GLU A 605
LEU A 540
ARG A 536
None
0.80A 6d8fA-4bc7A:
undetectable
6d8fA-4bc7A:
23.58