SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX8_A_RTLA135_0 (CELLULAR RETINOL-BINDING PROTEIN I, HOLO)	4bcx	AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 (Homo sapiens)	5 / 12	PHE A 745 LEU A 725 ALA A 715 ARG A 760 ILE A 712	None	1.31A	1mx8A-4bcxA: undetectable	1mx8A-4bcxA: 18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4POO_A_SAMA301_0 (PUTATIVE RNA METHYLASE)	4bcx	AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 (Homo sapiens)	5 / 12	THR A 701 GLY A 738 ILE A 741 LEU A 739 THR A 699	None	1.21A	4pooA-4bcxA: undetectable	4pooA-4bcxA: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TIW_A_OAQA302_0 (SULFOTRANSFERASE)	4bcx	AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 (Homo sapiens)	5 / 12	ILE A 696 LEU A 748 VAL A 717 LEU A 682 LEU A 759	None None IMD A1786 ( 4.8A) None None	1.22A	5tiwA-4bcxA: undetectable	5tiwA-4bcxA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_B_BEZB201_0 (NS3 PROTEASE)	4bcx	AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 (Homo sapiens)	4 / 5	HIS A 765 ALA A 735 SER A 704 GLY A 677	None	0.89A	5yodB-4bcxA: undetectable	5yodB-4bcxA: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_D_BEZD201_0 (NS3 PROTEASE)	4bcx	AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 (Homo sapiens)	4 / 5	HIS A 765 ALA A 735 SER A 704 GLY A 677	None	1.00A	5yodD-4bcxA: undetectable	5yodD-4bcxA: 21.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX8_A_RTLA135_0","CELLULAR RETINOL-BINDING PROTEIN I, HOLO","4bcx","AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2","Homo sapiens",5,"PHE A 745;LEU A 725;ALA A 715;ARG A 760;ILE A 712","None","1.31A","1mx8A-4bcxA:undetectable","1mx8A-4bcxA:18.62"],["4POO_A_SAMA301_0","PUTATIVE RNA METHYLASE","4bcx","AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2","Homo sapiens",5,"THR A 701;GLY A 738;ILE A 741;LEU A 739;THR A 699","None","1.21A","4pooA-4bcxA:undetectable","4pooA-4bcxA:21.00"],["5TIW_A_OAQA302_0","SULFOTRANSFERASE","4bcx","AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2","Homo sapiens",5,"ILE A 696;LEU A 748;VAL A 717;LEU A 682;LEU A 759","None;None;IMD A1786 ( 4.8A);None;None","1.22A","5tiwA-4bcxA:undetectable","5tiwA-4bcxA:21.13"],["5YOD_B_BEZB201_0","NS3 PROTEASE","4bcx","AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2","Homo sapiens",4,"HIS A 765;ALA A 735;SER A 704;GLY A 677","None","0.89A","5yodB-4bcxA:undetectable","5yodB-4bcxA:21.91"],["5YOD_D_BEZD201_0","NS3 PROTEASE","4bcx","AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2","Homo sapiens",4,"HIS A 765;ALA A 735;SER A 704;GLY A 677","None","1.00A","5yodD-4bcxA:undetectable","5yodD-4bcxA:21.91"]]