SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4be3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H1D_A_SAMA301_0 (CATECHOL-O-METHYLTRA NSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	VAL A 174 GLY A 146 TYR A 163 TYR A 299 GLN A 292	None	1.21A	1h1dA-4be3A: undetectable	1h1dA-4be3A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_SAMB1293_1 (GLYCINE N-METHYLTRANSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 5	ARG A 278 SER A 142 ASN A 91 SER A 314	None	1.34A	1kiaB-4be3A: undetectable	1kiaB-4be3A: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_C_SAMC2293_1 (GLYCINE N-METHYLTRANSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	ARG A 278 SER A 142 ASN A 91 SER A 314	None	1.32A	1kiaC-4be3A: undetectable	1kiaC-4be3A: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NSI_A_H4BA600_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.17A	1nsiA-4be3A: undetectable 1nsiB-4be3A: undetectable	1nsiA-4be3A: 21.10 1nsiB-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NSI_B_H4BB601_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.18A	1nsiA-4be3A: undetectable 1nsiB-4be3A: undetectable	1nsiA-4be3A: 21.10 1nsiB-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NSI_C_H4BC602_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.20A	1nsiC-4be3A: undetectable 1nsiD-4be3A: undetectable	1nsiC-4be3A: 21.10 1nsiD-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NSI_D_H4BD603_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.17A	1nsiC-4be3A: undetectable 1nsiD-4be3A: undetectable	1nsiC-4be3A: 21.10 1nsiD-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PNL_B_PACB559_0 (PENICILLIN AMIDOHYDROLASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	SER A 130 SER A 140 ALA A 317 ASN A 91	None	0.93A	1pnlA-4be3A: undetectable 1pnlB-4be3A: undetectable	1pnlA-4be3A: 20.99 1pnlB-4be3A: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVD_B_SAMB601_0 (CATECHOL-O-METHYLTRA NSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	GLY A 133 TYR A 333 VAL A 137 ALA A 208 ASP A 318	None	1.42A	2avdB-4be3A: undetectable	2avdB-4be3A: 17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_A_H4BA600_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.18A	2nsiA-4be3A: undetectable 2nsiB-4be3A: undetectable	2nsiA-4be3A: 21.10 2nsiB-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_B_H4BB601_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.17A	2nsiA-4be3A: undetectable 2nsiB-4be3A: undetectable	2nsiA-4be3A: 21.10 2nsiB-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_C_H4BC602_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.19A	2nsiC-4be3A: undetectable 2nsiD-4be3A: undetectable	2nsiC-4be3A: 21.10 2nsiD-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_D_H4BD603_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.18A	2nsiC-4be3A: undetectable 2nsiD-4be3A: undetectable	2nsiC-4be3A: 21.10 2nsiD-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_A_SAMA301_0 (UPF0217 PROTEIN AF_1056)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 9	LEU A 120 GLU A 228 GLY A 118 GLY A 346 LEU A 238	None	1.20A	2qmmA-4be3A: undetectable	2qmmA-4be3A: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_A_RIMA199_1 (MATRIX PROTEIN 2)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	LEU A 106 LEU A 296 ILE A 54 ARG A 103	None None None SRT A 400 (-3.6A)	1.03A	2rlfA-4be3A: undetectable 2rlfB-4be3A: undetectable	2rlfA-4be3A: 8.17 2rlfB-4be3A: 8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_C_RIMC399_1 (MATRIX PROTEIN 2)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	LEU A 106 LEU A 296 ILE A 54 ARG A 103	None None None SRT A 400 (-3.6A)	0.99A	2rlfC-4be3A: undetectable 2rlfD-4be3A: undetectable	2rlfC-4be3A: 8.17 2rlfD-4be3A: 8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VQY_A_PARA1201_1 (AAC(6')-IB)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	GLY A 153 TYR A 287 LEU A 254 GLU A 115 GLN A 292	None	1.35A	2vqyA-4be3A: undetectable	2vqyA-4be3A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_B_SALB1304_1 (LYSR-TYPE REGULATORY PROTEIN)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 10	THR A 102 ILE A 94 GLY A 57 PHE A 73 ILE A 324	None	1.07A	2y7kB-4be3A: undetectable	2y7kB-4be3A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_C_SALC1302_1 (LYSR-TYPE REGULATORY PROTEIN)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	THR A 102 ILE A 94 GLY A 57 PHE A 73 ILE A 324	None	1.00A	2y7kC-4be3A: undetectable	2y7kC-4be3A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_D_SALD1300_1 (LYSR-TYPE REGULATORY PROTEIN)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	THR A 102 ILE A 94 GLY A 57 PHE A 73 ILE A 324	None	0.99A	2y7kD-4be3A: undetectable	2y7kD-4be3A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZTH_A_SAMA305_0 (CATECHOL O-METHYLTRANSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	VAL A 174 GLY A 146 TYR A 163 TYR A 299 GLN A 108	None	1.47A	2zthA-4be3A: undetectable	2zthA-4be3A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZTH_A_SAMA305_0 (CATECHOL O-METHYLTRANSFERASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 12	VAL A 174 GLY A 146 TYR A 163 TYR A 299 GLN A 292	None	1.17A	2zthA-4be3A: undetectable	2zthA-4be3A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_D_NILD600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	LEU A 65 TYR A 68 LEU A 56 ASP A 71	None	0.82A	3cs9D-4be3A: undetectable	3cs9D-4be3A: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_A_H4BA902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.18A	3e7gA-4be3A: undetectable 3e7gB-4be3A: undetectable	3e7gA-4be3A: 21.35 3e7gB-4be3A: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_B_H4BB1902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.17A	3e7gA-4be3A: undetectable 3e7gB-4be3A: undetectable	3e7gA-4be3A: 21.35 3e7gB-4be3A: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_C_H4BC2902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.16A	3e7gC-4be3A: undetectable 3e7gD-4be3A: undetectable	3e7gC-4be3A: 21.35 3e7gD-4be3A: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_D_H4BD3902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.17A	3e7gC-4be3A: undetectable 3e7gD-4be3A: undetectable	3e7gC-4be3A: 21.35 3e7gD-4be3A: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ONN_A_ACTA271_0 (PROTEIN SSM1)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 5	GLY A 172 LYS A 171 GLU A 214 GLY A 218	None	1.06A	3onnA-4be3A: undetectable	3onnA-4be3A: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	LEU A 55 TYR A 299 SER A 96 HIS A 149	SRT A 400 ( 4.0A) None SRT A 400 ( 4.0A) SRT A 400 (-3.4A)	1.33A	4arcA-4be3A: undetectable	4arcA-4be3A: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_A_H4BA600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.14A	4cx7A-4be3A: undetectable 4cx7B-4be3A: undetectable	4cx7A-4be3A: 21.10 4cx7B-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.14A	4cx7A-4be3A: undetectable 4cx7B-4be3A: undetectable	4cx7A-4be3A: 21.10 4cx7B-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_C_H4BC600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.24A	4cx7C-4be3A: undetectable 4cx7D-4be3A: undetectable	4cx7C-4be3A: 21.10 4cx7D-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_D_H4BD600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.13A	4cx7C-4be3A: undetectable 4cx7D-4be3A: undetectable	4cx7C-4be3A: 21.10 4cx7D-4be3A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HXY_B_ACAB502_1 (PLM1)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	SER A 99 GLN A 301 TYR A 299 ASP A 191	None	1.06A	4hxyB-4be3A: undetectable	4hxyB-4be3A: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NOS_B_H4BB1011_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.20A	4nosA-4be3A: undetectable 4nosB-4be3A: undetectable	4nosA-4be3A: 21.85 4nosB-4be3A: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NOS_C_H4BC2011_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 7	ILE A 269 TRP A 190 PHE A 259 GLU A 179	None	1.18A	4nosC-4be3A: undetectable 4nosD-4be3A: undetectable	4nosC-4be3A: 21.85 4nosD-4be3A: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NOS_D_H4BD3011_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 6	TRP A 190 PHE A 259 GLU A 179 ILE A 269	None	1.21A	4nosC-4be3A: undetectable 4nosD-4be3A: undetectable	4nosC-4be3A: 21.85 4nosD-4be3A: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJ7_A_ADNA303_1 (5'/3'-NUCLEOTIDASE SURE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 10	GLY A 297 ALA A 69 ILE A 54 PRO A 42 LEU A 106	None	1.23A	4xj7A-4be3A: undetectable 4xj7B-4be3A: undetectable	4xj7A-4be3A: 21.56 4xj7B-4be3A: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_C_FK5C201_1 (FK506-BINDING PROTEIN 1)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	5 / 10	VAL A 145 ILE A 161 LEU A 238 PHE A 240 ILE A 46	None	1.34A	5hw8C-4be3A: undetectable 5hw8H-4be3A: undetectable	5hw8C-4be3A: 20.00 5hw8H-4be3A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VW5_A_NCAA403_0 (FERREDOXIN--NADP REDUCTASE)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	SER A 132 THR A 315 GLY A 316 GLY A 304	None	0.70A	5vw5A-4be3A: undetectable	5vw5A-4be3A: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_A_SAMA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	3 / 3	HIS A 149 GLU A 179 ASN A 186	SRT A 400 (-3.4A) None None	1.01A	5wbvA-4be3A: undetectable	5wbvA-4be3A: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_B_SAMB402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	3 / 3	HIS A 149 GLU A 179 ASN A 186	SRT A 400 (-3.4A) None None	1.02A	5wbvB-4be3A: undetectable	5wbvB-4be3A: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNJ_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	4be3	ALGINATE LYASE, FAMILY PL7 (Zobellia galactanivorans)	4 / 8	TYR A 75 THR A 89 TYR A 328 LEU A 56	None	1.43A	6cnjD-4be3A: undetectable 6cnjE-4be3A: undetectable	6cnjD-4be3A: 15.02 6cnjE-4be3A: 15.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H1D_A_SAMA301_0","CATECHOL-O-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"VAL A 174;GLY A 146;TYR A 163;TYR A 299;GLN A 292","None","1.21A","1h1dA-4be3A:undetectable","1h1dA-4be3A:20.73"],["1KIA_B_SAMB1293_1","GLYCINE N-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ARG A 278;SER A 142;ASN A  91;SER A 314","None","1.34A","1kiaB-4be3A:undetectable","1kiaB-4be3A:21.57"],["1KIA_C_SAMC2293_1","GLYCINE N-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ARG A 278;SER A 142;ASN A  91;SER A 314","None","1.32A","1kiaC-4be3A:undetectable","1kiaC-4be3A:21.57"],["1NSI_A_H4BA600_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.17A","1nsiA-4be3A:undetectable;1nsiB-4be3A:undetectable","1nsiA-4be3A:21.10;1nsiB-4be3A:21.10"],["1NSI_B_H4BB601_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.18A","1nsiA-4be3A:undetectable;1nsiB-4be3A:undetectable","1nsiA-4be3A:21.10;1nsiB-4be3A:21.10"],["1NSI_C_H4BC602_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.20A","1nsiC-4be3A:undetectable;1nsiD-4be3A:undetectable","1nsiC-4be3A:21.10;1nsiD-4be3A:21.10"],["1NSI_D_H4BD603_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.17A","1nsiC-4be3A:undetectable;1nsiD-4be3A:undetectable","1nsiC-4be3A:21.10;1nsiD-4be3A:21.10"],["1PNL_B_PACB559_0","PENICILLIN AMIDOHYDROLASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"SER A 130;SER A 140;ALA A 317;ASN A  91","None","0.93A","1pnlA-4be3A:undetectable;1pnlB-4be3A:undetectable","1pnlA-4be3A:20.99;1pnlB-4be3A:21.04"],["2AVD_B_SAMB601_0","CATECHOL-O-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"GLY A 133;TYR A 333;VAL A 137;ALA A 208;ASP A 318","None","1.42A","2avdB-4be3A:undetectable","2avdB-4be3A:17.13"],["2NSI_A_H4BA600_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.18A","2nsiA-4be3A:undetectable;2nsiB-4be3A:undetectable","2nsiA-4be3A:21.10;2nsiB-4be3A:21.10"],["2NSI_B_H4BB601_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.17A","2nsiA-4be3A:undetectable;2nsiB-4be3A:undetectable","2nsiA-4be3A:21.10;2nsiB-4be3A:21.10"],["2NSI_C_H4BC602_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.19A","2nsiC-4be3A:undetectable;2nsiD-4be3A:undetectable","2nsiC-4be3A:21.10;2nsiD-4be3A:21.10"],["2NSI_D_H4BD603_1","PROTEIN (NITRIC OXIDE SYNTHASE);PROTEIN (NITRIC OXIDE SYNTHASE)","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.18A","2nsiC-4be3A:undetectable;2nsiD-4be3A:undetectable","2nsiC-4be3A:21.10;2nsiD-4be3A:21.10"],["2QMM_A_SAMA301_0","UPF0217 PROTEIN AF_1056","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"LEU A 120;GLU A 228;GLY A 118;GLY A 346;LEU A 238","None","1.20A","2qmmA-4be3A:undetectable","2qmmA-4be3A:19.29"],["2RLF_A_RIMA199_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"LEU A 106;LEU A 296;ILE A  54;ARG A 103","None;None;None;SRT A 400 (-3.6A)","1.03A","2rlfA-4be3A:undetectable;2rlfB-4be3A:undetectable","2rlfA-4be3A:8.17;2rlfB-4be3A:8.17"],["2RLF_C_RIMC399_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"LEU A 106;LEU A 296;ILE A  54;ARG A 103","None;None;None;SRT A 400 (-3.6A)","0.99A","2rlfC-4be3A:undetectable;2rlfD-4be3A:undetectable","2rlfC-4be3A:8.17;2rlfD-4be3A:8.17"],["2VQY_A_PARA1201_1","AAC(6')-IB","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"GLY A 153;TYR A 287;LEU A 254;GLU A 115;GLN A 292","None","1.35A","2vqyA-4be3A:undetectable","2vqyA-4be3A:20.00"],["2Y7K_B_SALB1304_1","LYSR-TYPE REGULATORY PROTEIN","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"THR A 102;ILE A  94;GLY A  57;PHE A  73;ILE A 324","None","1.07A","2y7kB-4be3A:undetectable","2y7kB-4be3A:18.91"],["2Y7K_C_SALC1302_1","LYSR-TYPE REGULATORY PROTEIN","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"THR A 102;ILE A  94;GLY A  57;PHE A  73;ILE A 324","None","1.00A","2y7kC-4be3A:undetectable","2y7kC-4be3A:18.91"],["2Y7K_D_SALD1300_1","LYSR-TYPE REGULATORY PROTEIN","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"THR A 102;ILE A  94;GLY A  57;PHE A  73;ILE A 324","None","0.99A","2y7kD-4be3A:undetectable","2y7kD-4be3A:18.91"],["2ZTH_A_SAMA305_0","CATECHOL O-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"VAL A 174;GLY A 146;TYR A 163;TYR A 299;GLN A 108","None","1.47A","2zthA-4be3A:undetectable","2zthA-4be3A:20.73"],["2ZTH_A_SAMA305_0","CATECHOL O-METHYLTRANSFERASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"VAL A 174;GLY A 146;TYR A 163;TYR A 299;GLN A 292","None","1.17A","2zthA-4be3A:undetectable","2zthA-4be3A:20.73"],["3CS9_D_NILD600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"LEU A  65;TYR A  68;LEU A  56;ASP A  71","None","0.82A","3cs9D-4be3A:undetectable","3cs9D-4be3A:22.32"],["3E7G_A_H4BA902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.18A","3e7gA-4be3A:undetectable;3e7gB-4be3A:undetectable","3e7gA-4be3A:21.35;3e7gB-4be3A:21.35"],["3E7G_B_H4BB1902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.17A","3e7gA-4be3A:undetectable;3e7gB-4be3A:undetectable","3e7gA-4be3A:21.35;3e7gB-4be3A:21.35"],["3E7G_C_H4BC2902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.16A","3e7gC-4be3A:undetectable;3e7gD-4be3A:undetectable","3e7gC-4be3A:21.35;3e7gD-4be3A:21.35"],["3E7G_D_H4BD3902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.17A","3e7gC-4be3A:undetectable;3e7gD-4be3A:undetectable","3e7gC-4be3A:21.35;3e7gD-4be3A:21.35"],["3ONN_A_ACTA271_0","PROTEIN SSM1","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"GLY A 172;LYS A 171;GLU A 214;GLY A 218","None","1.06A","3onnA-4be3A:undetectable","3onnA-4be3A:21.39"],["4ARC_A_LEUA1001_0","LEUCINE--TRNA LIGASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"LEU A  55;TYR A 299;SER A  96;HIS A 149","SRT A 400 ( 4.0A);None;SRT A 400 ( 4.0A);SRT A 400 (-3.4A)","1.33A","4arcA-4be3A:undetectable","4arcA-4be3A:16.92"],["4CX7_A_H4BA600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.14A","4cx7A-4be3A:undetectable;4cx7B-4be3A:undetectable","4cx7A-4be3A:21.10;4cx7B-4be3A:21.10"],["4CX7_B_H4BB600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.14A","4cx7A-4be3A:undetectable;4cx7B-4be3A:undetectable","4cx7A-4be3A:21.10;4cx7B-4be3A:21.10"],["4CX7_C_H4BC600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.24A","4cx7C-4be3A:undetectable;4cx7D-4be3A:undetectable","4cx7C-4be3A:21.10;4cx7D-4be3A:21.10"],["4CX7_D_H4BD600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.13A","4cx7C-4be3A:undetectable;4cx7D-4be3A:undetectable","4cx7C-4be3A:21.10;4cx7D-4be3A:21.10"],["4HXY_B_ACAB502_1","PLM1","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"SER A  99;GLN A 301;TYR A 299;ASP A 191","None","1.06A","4hxyB-4be3A:undetectable","4hxyB-4be3A:20.86"],["4NOS_B_H4BB1011_1","INDUCIBLE NITRIC OXIDE SYNTHASE;INDUCIBLE NITRIC OXIDE SYNTHASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.20A","4nosA-4be3A:undetectable;4nosB-4be3A:undetectable","4nosA-4be3A:21.85;4nosB-4be3A:21.85"],["4NOS_C_H4BC2011_1","INDUCIBLE NITRIC OXIDE SYNTHASE;INDUCIBLE NITRIC OXIDE SYNTHASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"ILE A 269;TRP A 190;PHE A 259;GLU A 179","None","1.18A","4nosC-4be3A:undetectable;4nosD-4be3A:undetectable","4nosC-4be3A:21.85;4nosD-4be3A:21.85"],["4NOS_D_H4BD3011_1","INDUCIBLE NITRIC OXIDE SYNTHASE;INDUCIBLE NITRIC OXIDE SYNTHASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TRP A 190;PHE A 259;GLU A 179;ILE A 269","None","1.21A","4nosC-4be3A:undetectable;4nosD-4be3A:undetectable","4nosC-4be3A:21.85;4nosD-4be3A:21.85"],["4XJ7_A_ADNA303_1","5'\/3'-NUCLEOTIDASE SURE;5'\/3'-NUCLEOTIDASE SURE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"GLY A 297;ALA A  69;ILE A  54;PRO A  42;LEU A 106","None","1.23A","4xj7A-4be3A:undetectable;4xj7B-4be3A:undetectable","4xj7A-4be3A:21.56;4xj7B-4be3A:21.56"],["5HW8_C_FK5C201_1","FK506-BINDING PROTEIN 1;FK506-BINDING PROTEIN 1","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",5,"VAL A 145;ILE A 161;LEU A 238;PHE A 240;ILE A  46","None","1.34A","5hw8C-4be3A:undetectable;5hw8H-4be3A:undetectable","5hw8C-4be3A:20.00;5hw8H-4be3A:20.00"],["5VW5_A_NCAA403_0","FERREDOXIN--NADP REDUCTASE","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"SER A 132;THR A 315;GLY A 316;GLY A 304","None","0.70A","5vw5A-4be3A:undetectable","5vw5A-4be3A:23.77"],["5WBV_A_SAMA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",3,"HIS A 149;GLU A 179;ASN A 186","SRT A 400 (-3.4A);None;None","1.01A","5wbvA-4be3A:undetectable","5wbvA-4be3A:23.21"],["5WBV_B_SAMB402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",3,"HIS A 149;GLU A 179;ASN A 186","SRT A 400 (-3.4A);None;None","1.02A","5wbvB-4be3A:undetectable","5wbvB-4be3A:23.21"],["6CNJ_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","4be3","ALGINATE LYASE, FAMILY PL7","Zobellia galactanivorans",4,"TYR A  75;THR A  89;TYR A 328;LEU A  56","None","1.43A","6cnjD-4be3A:undetectable;6cnjE-4be3A:undetectable","6cnjD-4be3A:15.02;6cnjE-4be3A:15.72"]]