SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 9 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 1.01A 1hpvB-4bemJ:
undetectable		 1hpvB-4bemJ:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 10 GLY J 122
ALA J 121
ILE J 117
GLY J 116
ILE J  88
 None
 1.02A 1t7iA-4bemJ:
undetectable		 1t7iA-4bemJ:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 12 GLY A  24
GLY A  65
THR J 164
GLU A  62
GLN A  29
 None
None
NA  A 201 ( 4.2A)
NA  A 201 (-2.7A)
NA  A 201 (-2.6A)
 1.33A 2akeA-4bemA:
undetectable		 2akeA-4bemA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 11 GLY A  24
GLY A  65
THR J 164
GLU A  62
GLN A  29
 None
None
NA  A 201 ( 4.2A)
NA  A 201 (-2.7A)
NA  A 201 (-2.6A)
 1.31A 2dr2A-4bemA:
undetectable		 2dr2A-4bemA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		6 / 12 THR J 127
GLY A  22
GLY A  26
GLY A  68
ILE J 123
ALA J 121
 None
 1.09A 2fk8A-4bemJ:
undetectable		 2fk8A-4bemJ:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		4 / 6 LEU J  92
ASN J  96
ILE J  24
ALA J 112
 None
 0.95A 2j5mA-4bemJ:
undetectable		 2j5mA-4bemJ:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bem F1FO ATPASE C2
SUBUNIT
(Acetobacterium
woodii) 		4 / 6 LEU A  75
ASN A  79
PHE A  82
ILE A   7
 None
 0.96A 2j5mA-4bemA:
undetectable		 2j5mA-4bemA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		4 / 6 LEU J 175
ASN J 179
ILE J 107
ALA A  12
 None
 0.87A 2j5mA-4bemJ:
undetectable		 2j5mA-4bemJ:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 12 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 0.96A 2o4sA-4bemJ:
undetectable		 2o4sA-4bemJ:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 12 GLY A  36
GLY A  34
GLY A  30
ILE A  50
VAL J 153
 None
None
None
None
HTG  J1184 ( 4.5A)
 0.98A 2oxtC-4bemA:
undetectable		 2oxtC-4bemA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 9 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 0.93A 2q5kA-4bemJ:
undetectable		 2q5kA-4bemJ:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 11 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 1.01A 2qhcA-4bemJ:
undetectable		 2qhcA-4bemJ:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 12 GLY J 116
ALA J 112
ALA J  38
VAL J  37
PHE J  84
 None
None
None
None
HTG  J1187 ( 4.7A)
 1.27A 2yvlC-4bemJ:
undetectable		 2yvlC-4bemJ:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 6 GLY J 124
GLY J 126
GLY J  41
GLY J 122
GLY J  39
 None
 0.91A 3bogB-4bemJ:
undetectable
3bogD-4bemJ:
undetectable		 3bogB-4bemJ:
undetectable
3bogD-4bemJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		4 / 5 PRO J  20
SER J  16
LEU J 108
SER J 109
 None
 1.35A 3iluH-4bemJ:
undetectable		 3iluH-4bemJ:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
F1FO ATPASE C2
SUBUNIT
(Acetobacterium
woodii) 		5 / 9 GLY J 122
ALA J 121
ILE A  20
GLY J 116
ILE J  88
 None
 0.88A 3ogpA-4bemJ:
undetectable		 3ogpA-4bemJ:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		4 / 6 GLY J 130
ALA J 132
TYR J 131
GLU J 138
 None
 0.94A 4ae1A-4bemJ:
undetectable		 4ae1A-4bemJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 10 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 1.10A 4dqcA-4bemJ:
undetectable		 4dqcA-4bemJ:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 9 ALA J 161
GLY A  22
ILE J 123
GLY J 124
ILE A  27
 None
 1.08A 4eatB-4bemJ:
undetectable		 4eatB-4bemJ:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 12 ALA J  78
GLY J 134
GLY J 130
GLY A  30
ALA J  50
 None
 0.82A 5c0oG-4bemJ:
undetectable		 5c0oG-4bemJ:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4bem F1FO ATPASE C1
SUBUNIT
F1FO ATPASE C2
SUBUNIT
(Acetobacterium
woodii) 		4 / 8 VAL J  77
GLY A  26
GLN J 162
THR J 164
 HTG  J1186 (-4.7A)
None
HTG  J1186 (-4.4A)
NA  A 201 ( 4.2A)
 1.02A 5sxqB-4bemJ:
undetectable		 5sxqB-4bemJ:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4bem F1FO ATPASE C1
SUBUNIT
F1FO ATPASE C2
SUBUNIT
(Acetobacterium
woodii) 		4 / 8 VAL J  77
GLY A  26
GLN J 162
THR J 164
 HTG  J1186 (-4.7A)
None
HTG  J1186 (-4.4A)
NA  A 201 ( 4.2A)
 1.02A 5syjA-4bemJ:
undetectable		 5syjA-4bemJ:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii;
Acetobacterium
woodii) 		5 / 12 GLY J 122
GLY J 128
GLY J 126
VAL J  40
ALA A  33
 None
 1.16A 5x7fA-4bemJ:
undetectable		 5x7fA-4bemJ:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 9 ALA J 112
SER J 109
ALA J  29
SER J  28
GLY J  31
 None
 0.94A 6bklE-4bemJ:
undetectable
6bklF-4bemJ:
undetectable
6bklG-4bemJ:
undetectable
6bklH-4bemJ:
undetectable		 6bklE-4bemJ:
9.77
6bklF-4bemJ:
9.77
6bklG-4bemJ:
9.77
6bklH-4bemJ:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 9 ALA J 112
SER J 109
ALA J  29
SER J  28
GLY J  31
 None
 0.99A 6bklE-4bemJ:
undetectable
6bklF-4bemJ:
undetectable
6bklG-4bemJ:
undetectable
6bklH-4bemJ:
undetectable		 6bklE-4bemJ:
9.77
6bklF-4bemJ:
9.77
6bklG-4bemJ:
9.77
6bklH-4bemJ:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		4 / 6 ALA J 112
SER J 109
ALA J  29
SER J  28
 None
 0.93A 6bocA-4bemJ:
undetectable
6bocB-4bemJ:
undetectable
6bocC-4bemJ:
undetectable
6bocD-4bemJ:
undetectable		 6bocA-4bemJ:
9.77
6bocB-4bemJ:
9.77
6bocC-4bemJ:
9.77
6bocD-4bemJ:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		5 / 10 ALA J 172
GLY J 165
ILE J 166
VAL J  87
ILE J  88
 None
None
None
HTG  J1187 (-4.5A)
None
 0.93A 6dj2A-4bemJ:
undetectable		 6dj2A-4bemJ:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4bem F1FO ATPASE C1
SUBUNIT
(Acetobacterium
woodii) 		4 / 8 MET J 154
TYR J 131
GLY J 126
SER J  81
 None
 1.12A 6giqL-4bemJ:
undetectable
6giqP-4bemJ:
undetectable
6giqT-4bemJ:
undetectable		 6giqL-4bemJ:
17.47
6giqP-4bemJ:
22.57
6giqT-4bemJ:
15.56