SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4beq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 8 GLU A 138
ARG A 119
LEU A 149
LEU A 132
 None
 0.93A 1cmaA-4beqA:
undetectable
1cmaB-4beqA:
undetectable		 1cmaA-4beqA:
15.71
1cmaB-4beqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 11 GLU A 138
ARG A 119
LEU A 149
ALA A 153
LEU A 132
 None
 1.06A 1mjlA-4beqA:
undetectable
1mjlB-4beqA:
undetectable		 1mjlA-4beqA:
15.40
1mjlB-4beqA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		3 / 3 ASN A 250
TYR A 275
SER A 245
 None
None
PLP  A1350 (-2.5A)
 0.87A 2gvcB-4beqA:
undetectable		 2gvcB-4beqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		3 / 3 ASN A 250
TYR A 275
SER A 245
 None
None
PLP  A1350 (-2.5A)
 0.91A 2gvcE-4beqA:
undetectable		 2gvcE-4beqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 GLY A  98
PRO A 261
GLY A 262
GLU A 137
ILE A 136
 None
None
PLP  A1350 (-3.5A)
None
None
 0.96A 2plwA-4beqA:
undetectable		 2plwA-4beqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		3 / 3 ASP A 211
ASN A 209
THR A 271
 None
 0.53A 2pymB-4beqA:
undetectable		 2pymB-4beqA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 GLU A 186
GLY A 183
VAL A 198
GLY A 141
ILE A 190
 None
 1.08A 3k13A-4beqA:
8.7		 3k13A-4beqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 GLU A 186
GLY A 183
VAL A 198
GLY A 141
ILE A 190
 None
 1.09A 3k13C-4beqA:
8.3		 3k13C-4beqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 10 GLY A 398
ASP A  76
ALA A  77
GLY A  79
VAL A 279
 None
 1.28A 4c5nD-4beqA:
2.8		 4c5nD-4beqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 8 SER A 346
THR A 302
MET A 326
GLY A 327
 None
 0.96A 4fo4A-4beqA:
6.5		 4fo4A-4beqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 ALA A 248
MET A  63
ILE A  94
PRO A  95
TYR A 275
 None
 1.38A 4gh8B-4beqA:
undetectable		 4gh8B-4beqA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 256
GLY A 169
ASN A 167
PHE A 220
GLY A 175
 None
 1.16A 4n09A-4beqA:
undetectable		 4n09A-4beqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 117
GLU A 110
VAL A 108
ARG A 106
GLU A 127
 None
 1.27A 4q15B-4beqA:
undetectable		 4q15B-4beqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 7 ALA A  77
ILE A 278
LEU A 265
PHE A 266
 None
 1.12A 4uymB-4beqA:
undetectable		 4uymB-4beqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 117
GLU A 110
VAL A 108
ARG A 106
GLU A 127
 None
 1.26A 4ydqA-4beqA:
undetectable		 4ydqA-4beqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 11 ALA A 254
GLU A 253
LEU A 217
GLY A 169
HIS A 204
 None
None
None
None
PLP  A1350 (-3.1A)
 1.21A 5dxgB-4beqA:
undetectable		 5dxgB-4beqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 117
GLU A 110
VAL A 108
ARG A 106
GLU A 127
 None
 1.27A 5f9zA-4beqA:
undetectable		 5f9zA-4beqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 5 VAL A 297
THR A 305
ASP A 353
LEU A 311
 None
 1.24A 5m0iB-4beqA:
undetectable		 5m0iB-4beqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 GLY A 267
ILE A 278
VAL A 379
ASN A  80
LEU A  85
 None
 1.36A 5nz0A-4beqA:
undetectable		 5nz0A-4beqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 GLU A 186
GLY A 183
VAL A 198
GLY A 141
ILE A 190
 None
 1.13A 5vooE-4beqA:
8.5		 5vooE-4beqA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 117
GLU A 110
VAL A 108
ARG A 106
GLU A 127
 None
 1.27A 5xiqB-4beqA:
undetectable		 5xiqB-4beqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		5 / 12 LEU A 117
GLU A 110
VAL A 108
ARG A 106
GLU A 127
 None
 1.24A 5xiqD-4beqA:
undetectable		 5xiqD-4beqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		3 / 3 TYR A 275
HIS A  62
MET A  63
 None
 1.10A 6af6A-4beqA:
undetectable		 6af6A-4beqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 6 SER A 124
ALA A 131
SER A 130
ALA A 123
 None
 0.98A 6bocA-4beqA:
undetectable
6bocB-4beqA:
undetectable
6bocC-4beqA:
undetectable
6bocD-4beqA:
undetectable		 6bocA-4beqA:
4.55
6bocB-4beqA:
4.55
6bocC-4beqA:
4.55
6bocD-4beqA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4beq ALANINE RACEMASE 2
(Vibrio
cholerae) 		4 / 5 SER A 280
VAL A 279
ASN A  80
PRO A 276
 None
 1.46A 6fi4A-4beqA:
undetectable
6fi4B-4beqA:
undetectable		 6fi4A-4beqA:
20.79
6fi4B-4beqA:
4.07