SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ber'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 7 LEU A  49
TYR A  41
THR A 257
ASN A 242
 None
C5P  A1000 (-3.5A)
None
None
 1.36A 1afsA-4berA:
undetectable		 1afsA-4berA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 7 LEU A  49
TYR A  41
THR A 257
ASN A 242
 None
C5P  A1000 (-3.5A)
None
None
 1.36A 1afsB-4berA:
undetectable		 1afsB-4berA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 HIS A 337
ILE A 287
GLN A  15
TYR A  12
GLU A 288
 None
 1.34A 1ki3A-4berA:
undetectable		 1ki3A-4berA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		3 / 3 ALA A 396
HIS A 397
VAL A 400
 None
 0.44A 1lqtB-4berA:
undetectable		 1lqtB-4berA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		3 / 3 ALA A 396
HIS A 397
VAL A 400
 None
 0.48A 1lquB-4berA:
undetectable		 1lquB-4berA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 LEU A  76
GLY A 236
TYR A 225
ILE A  80
LEU A   8
 None
C5P  A1000 (-3.3A)
None
None
None
 1.09A 1p91B-4berA:
undetectable		 1p91B-4berA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 ALA A 396
ILE A 401
SER A 402
ALA A 428
ILE A 378
 None
 1.12A 1ve3A-4berA:
undetectable		 1ve3A-4berA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 LEU A 194
LEU A 228
GLU A 226
CYH A  84
ASN A 235
 None
None
PO4  A2000 (-3.4A)
None
None
 1.31A 2bm9B-4berA:
undetectable		 2bm9B-4berA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 6 TRP A  23
ILE A  22
ARG A  24
LEU A  25
 None
 1.01A 2rlfA-4berA:
undetectable
2rlfD-4berA:
undetectable		 2rlfA-4berA:
6.13
2rlfD-4berA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 7 LEU A  25
ALA A  52
LEU A  49
PHE A 311
 None
 0.84A 2vcvG-4berA:
undetectable		 2vcvG-4berA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 8 LEU A  25
ALA A  52
LEU A  49
PHE A 311
 None
 0.79A 2vcvP-4berA:
undetectable		 2vcvP-4berA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 10 LEU A 128
VAL A 227
SER A 200
ILE A 197
PHE A 127
 None
 1.01A 2w9hA-4berA:
undetectable		 2w9hA-4berA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 9 VAL A 391
GLY A 112
ARG A 113
TYR A 267
GLY A 385
 None
 1.45A 3csjB-4berA:
undetectable		 3csjB-4berA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		3 / 3 TYR A 431
ASP A 462
HIS A 176
 None
 0.81A 3e23A-4berA:
undetectable		 3e23A-4berA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 GLU A  35
GLY A  47
ARG A  44
ALA A 234
ASP A  28
 None
None
C5P  A1000 (-3.4A)
C5P  A1000 (-3.5A)
C5P  A1000 (-2.2A)
 1.10A 3jzjA-4berA:
undetectable		 3jzjA-4berA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 7 TYR A 299
TYR A 359
LEU A 298
TYR A  17
 None
 0.97A 4f8yC-4berA:
undetectable
4f8yD-4berA:
undetectable		 4f8yC-4berA:
18.94
4f8yD-4berA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 PRO A   9
GLY A  10
ASN A   7
ILE A  59
LEU A  76
 None
 0.86A 4n48A-4berA:
undetectable		 4n48A-4berA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 PRO A   9
GLY A  10
ASN A   7
ILE A  59
LEU A  76
 None
 0.94A 4n49A-4berA:
undetectable		 4n49A-4berA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 6 TYR A 201
GLU A  69
GLN A 250
LEU A  72
 None
 1.38A 4qzuC-4berA:
undetectable		 4qzuC-4berA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		4 / 5 VAL A 457
HIS A 397
LEU A 445
ASP A 417
 None
 1.47A 5vcvA-4berA:
undetectable		 5vcvA-4berA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 GLU A 260
TYR A 201
VAL A 276
ASP A  28
PHE A 258
 None
None
None
C5P  A1000 (-2.2A)
GOL  A3000 ( 4.3A)
 1.49A 5vlmC-4berA:
1.0		 5vlmC-4berA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ber PHOSPHOCHOLINE
TRANSFERASE ANKX
(Legionella
pneumophila) 		5 / 12 PHE A 258
LEU A 347
ILE A 358
LEU A 244
LEU A 272
 GOL  A3000 ( 4.3A)
None
None
None
None
 1.41A 5ycpA-4berA:
undetectable		 5ycpA-4berA:
10.87