SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		3 / 3 ASP A 636
ARG A 416
ILE A 332
 None
 0.85A 1a4gB-4bevA:
undetectable		 1a4gB-4bevA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 8 SER A 723
VAL A 724
TYR A 688
VAL A 339
 None
 0.94A 1fduB-4bevA:
undetectable		 1fduB-4bevA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		3 / 3 ASN A 112
PHE A 188
VAL A 167
 None
 0.82A 1kijA-4bevA:
undetectable		 1kijA-4bevA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1874_0
(FPRA)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ALA A 191
PHE A 188
SER A 163
TRP A 160
 None
 1.32A 1lqtB-4bevA:
3.1		 1lqtB-4bevA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1431_0
(FPRA)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ALA A 191
PHE A 188
SER A 163
TRP A 160
 None
 1.32A 1lquB-4bevA:
2.7		 1lquB-4bevA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 LEU A 250
ALA A 306
LEU A 307
MET A 275
ILE A 258
 None
 1.26A 1mx8A-4bevA:
undetectable		 1mx8A-4bevA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 8 ASN A 677
SER A 673
ARG A 669
VAL A 734
 None
 1.19A 1u1jA-4bevA:
undetectable		 1u1jA-4bevA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 LEU A 682
PRO A 391
ALA A 389
ILE A 678
 None
 1.03A 2aofB-4bevA:
undetectable		 2aofB-4bevA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLN A 118
VAL A  96
MET A 100
MET A 717
THR A 195
 None
 1.33A 2q7kA-4bevA:
undetectable		 2q7kA-4bevA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 7 PRO A 383
ALA A 685
LEU A 386
ALA A 336
 None
 1.11A 2vcvA-4bevA:
undetectable		 2vcvA-4bevA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 7 PRO A 383
ALA A 685
LEU A 386
ALA A 336
 None
 1.05A 2vcvL-4bevA:
undetectable		 2vcvL-4bevA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		3 / 3 MET A 601
VAL A 574
GLU A 611
 None
 0.68A 2x9gA-4bevA:
5.5		 2x9gA-4bevA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 LEU A 511
MET A 539
VAL A 504
LEU A 481
LEU A 479
 None
 1.32A 3b0wB-4bevA:
undetectable		 3b0wB-4bevA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 8 ASP A 337
MET A 148
GLU A 415
GLU A 205
 None
 0.83A 3dh0A-4bevA:
2.3		 3dh0A-4bevA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 11 GLY A 638
GLY A 653
THR A 655
ARG A 329
ALA A 633
 None
 1.09A 3g88A-4bevA:
undetectable		 3g88A-4bevA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 11 GLY A 638
GLY A 653
THR A 655
ARG A 329
ALA A 633
 None
 1.06A 3g88B-4bevA:
undetectable		 3g88B-4bevA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLY A 638
GLY A 653
THR A 655
ARG A 329
ALA A 633
 None
 1.09A 3g89A-4bevA:
undetectable		 3g89A-4bevA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 11 GLY A 638
GLY A 653
THR A 655
ARG A 329
ALA A 633
 None
 1.09A 3g89B-4bevA:
undetectable		 3g89B-4bevA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLY A 638
GLY A 653
THR A 655
ARG A 329
ALA A 633
 None
 1.08A 3g8bB-4bevA:
undetectable		 3g8bB-4bevA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 11 SER A 404
ILE A 408
VAL A 654
VAL A 406
GLY A 401
 None
 0.85A 3kw4A-4bevA:
0.9		 3kw4A-4bevA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 LEU A 656
THR A 655
GLY A 623
ALA A 622
ALA A 620
 None
 1.10A 3p5nA-4bevA:
undetectable		 3p5nA-4bevA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 LEU A 656
THR A 655
GLY A 623
ALA A 622
ALA A 620
 None
 1.09A 3p5nB-4bevA:
undetectable		 3p5nB-4bevA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ASP A 553
GLU A 433
GLY A 434
GLU A 279
 None
 1.40A 3w9tA-4bevA:
undetectable		 3w9tA-4bevA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ASP A 553
GLU A 433
GLY A 434
GLU A 279
 None
 1.39A 3w9tC-4bevA:
undetectable		 3w9tC-4bevA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ASP A 553
GLU A 433
GLY A 434
GLU A 279
 None
 1.39A 3w9tD-4bevA:
undetectable		 3w9tD-4bevA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 ASP A 553
GLU A 433
GLY A 434
GLU A 279
 None
 1.40A 3w9tG-4bevA:
undetectable		 3w9tG-4bevA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 5 GLU A 603
SER A 606
ARG A 317
PRO A 602
 None
 1.40A 4k17B-4bevA:
undetectable		 4k17B-4bevA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 ALA A 540
ARG A 530
ILE A 470
LEU A 438
THR A 545
 None
 1.08A 4kfjB-4bevA:
2.2		 4kfjB-4bevA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 ASP A 542
VAL A 499
MET A 539
PHE A 446
LEU A 452
 None
 1.36A 4nc3A-4bevA:
2.7		 4nc3A-4bevA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 8 MET A 537
MET A 539
LEU A 438
ILE A 281
 None
 0.84A 4ok1A-4bevA:
undetectable		 4ok1A-4bevA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 11 ALA A 190
GLY A 155
GLY A 157
ALA A 159
SER A 163
 None
 1.04A 4qw1K-4bevA:
undetectable
4qw1L-4bevA:
undetectable		 4qw1K-4bevA:
15.67
4qw1L-4bevA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLY A 642
THR A 643
ALA A 640
LYS A 409
GLU A 650
 None
 1.16A 5hw4A-4bevA:
1.3		 5hw4A-4bevA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLY A 642
THR A 643
ALA A 640
LYS A 409
GLU A 650
 None
 1.17A 5hw4C-4bevA:
1.5		 5hw4C-4bevA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 12 GLY A 397
GLY A 399
LEU A 729
LEU A 731
ALA A 728
 None
 1.01A 5l0zA-4bevA:
4.1		 5l0zA-4bevA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 6 ASP A 426
LYS A 605
ASP A 628
ASN A 627
 MGF  A 950 ( 2.0A)
MGF  A 950 (-3.5A)
MGF  A 950 ( 4.2A)
MGF  A 950 (-3.2A)
 1.42A 5logA-4bevA:
2.9		 5logA-4bevA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		4 / 4 GLN A 211
THR A 212
GLU A 650
LEU A 407
 None
 1.36A 5m66A-4bevA:
2.4		 5m66A-4bevA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		3 / 3 LYS A 135
LEU A 199
ASP A  80
 None
 0.62A 5zv2A-4bevA:
undetectable		 5zv2A-4bevA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4bev COPPER EFFLUX ATPASE
(Legionella
pneumophila) 		5 / 10 VAL A 425
THR A 430
LEU A 591
ILE A 563
THR A 559
 None
 1.38A 6d9hR-4bevA:
3.2		 6d9hR-4bevA:
8.00