SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 MET A 190
LEU A 191
ILE A 176
GLY A 141
LEU A 139
 None
 1.26A 1g50B-4bf5A:
undetectable		 1g50B-4bf5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 11 MET A 190
LEU A 191
ILE A 176
GLY A 141
LEU A 139
 None
 1.24A 1g50C-4bf5A:
undetectable		 1g50C-4bf5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 8 ILE A 176
LEU A 178
LYS A 232
GLY A 231
 None
 1.00A 1os6A-4bf5A:
undetectable		 1os6A-4bf5A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		3 / 3 ILE A 164
ASP A 223
PHE A 220
 None
 0.53A 1uwjB-4bf5A:
undetectable		 1uwjB-4bf5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 7 MET A 352
THR A 303
PHE A 304
THR A 297
 None
 1.08A 2kotA-4bf5A:
undetectable		 2kotA-4bf5A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 ILE A  72
TYR A  78
THR A 396
LEU A 390
ARG A 173
 PLP  A1350 ( 3.6A)
PLP  A1350 (-4.4A)
None
None
PLP  A1350 (-3.9A)
 1.49A 2mjiA-4bf5A:
undetectable		 2mjiA-4bf5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 11 ALA A 122
LEU A 139
ILE A 164
GLY A 141
SER A 142
 None
 1.29A 3bpxA-4bf5A:
undetectable
3bpxB-4bf5A:
undetectable		 3bpxA-4bf5A:
16.96
3bpxB-4bf5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 9 THR A 350
ASN A 349
GLY A 318
ASP A 321
LEU A 369
 None
 1.50A 3sfuB-4bf5A:
undetectable		 3sfuB-4bf5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 9 GLY A 141
LEU A 227
LEU A 166
ASN A 174
ILE A 201
 None
None
None
CL  A1418 (-4.4A)
None
 1.00A 3wdmC-4bf5A:
undetectable		 3wdmC-4bf5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 11 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.05A 4c5lA-4bf5A:
2.4		 4c5lA-4bf5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 9 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.06A 4c5lB-4bf5A:
undetectable		 4c5lB-4bf5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 10 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.05A 4c5lC-4bf5A:
2.1		 4c5lC-4bf5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 10 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.04A 4c5lD-4bf5A:
2.2		 4c5lD-4bf5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 10 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.05A 4c5nB-4bf5A:
2.7		 4c5nB-4bf5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 5 VAL A 120
ARG A 119
MET A 118
GLU A 138
 PLP  A1350 ( 3.9A)
GOL  A1428 ( 4.3A)
None
None
 1.47A 4hojA-4bf5A:
undetectable		 4hojA-4bf5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		3 / 3 LYS A 407
ASN A  33
ASP A  47
 None
 0.89A 4o1eA-4bf5A:
8.2		 4o1eA-4bf5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 4 LYS A 407
ASN A  33
ASP A  76
ASP A  47
 None
 1.11A 4o1eB-4bf5A:
8.2		 4o1eB-4bf5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 MET A 190
LEU A 193
GLY A 195
GLN A 154
ILE A 164
 None
 1.01A 4udcA-4bf5A:
undetectable		 4udcA-4bf5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 7 ILE A 164
LEU A 227
LEU A 228
PRO A 198
 None
 1.02A 5u4sA-4bf5A:
undetectable		 5u4sA-4bf5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 MET A 394
ALA A 392
LEU A  44
TYR A 332
ASP A  47
 None
None
None
GOL  A1431 (-4.5A)
None
 1.43A 5vlmC-4bf5A:
undetectable		 5vlmC-4bf5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 GLY A 263
ASN A 244
ILE A  69
LEU A  58
PRO A  67
 PLP  A1350 (-3.8A)
PLP  A1350 ( 4.6A)
CL  A1421 ( 4.3A)
None
None
 1.08A 6b3aA-4bf5A:
2.4		 6b3aA-4bf5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		5 / 12 GLY A 263
ASN A 244
ILE A  69
LEU A  58
PRO A  67
 PLP  A1350 (-3.8A)
PLP  A1350 ( 4.6A)
CL  A1421 ( 4.3A)
None
None
 1.02A 6b3bA-4bf5A:
2.1		 6b3bA-4bf5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4bf5 ALANINE RACEMASE
(Aeromonas
hydrophila) 		4 / 6 ILE A 351
TYR A 323
LEU A 369
VAL A 342
 None
CL  A1419 ( 4.5A)
None
None
 1.24A 6f6jA-4bf5A:
undetectable		 6f6jA-4bf5A:
undetectable