SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 8 GLU A  64
ARG A  68
LEU A  13
GLU A  16
 None
ACT  A1337 ( 3.8A)
ACT  A1337 ( 3.4A)
ACT  A1337 (-3.1A)
 0.77A 1cmaA-4bf7A:
undetectable
1cmaB-4bf7A:
undetectable		 1cmaA-4bf7A:
16.08
1cmaB-4bf7A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 10 LEU A  80
VAL A 165
TYR A 113
GLY A 164
LEU A  78
 None
 1.32A 1fkoA-4bf7A:
undetectable		 1fkoA-4bf7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1874_0
(FPRA)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 5 TRP A  86
ALA A  87
SER A  83
TRP A  49
 None
 1.50A 1lqtB-4bf7A:
0.0		 1lqtB-4bf7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 4 LEU A 158
LEU A 203
SER A 204
LEU A 197
 None
IMD  A1342 ( 4.8A)
None
None
 1.17A 1ya3A-4bf7A:
undetectable		 1ya3A-4bf7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 4 GLY A 299
SER A  11
VAL A  20
LEU A 314
 None
 1.20A 1yajB-4bf7A:
undetectable		 1yajB-4bf7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 7 GLN A 189
LEU A 234
LEU A 243
GLY A 292
 None
 0.94A 2qqcD-4bf7A:
undetectable
2qqcE-4bf7A:
undetectable		 2qqcD-4bf7A:
18.15
2qqcE-4bf7A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 180
ILE A 210
SER A 230
PHE A 207
ALA A 155
 None
 1.36A 3lbdA-4bf7A:
undetectable		 3lbdA-4bf7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A   2
GLY A 331
 None
None
ZN  A 413 ( 4.7A)
None
None
 0.84A 3olsA-4bf7A:
undetectable		 3olsA-4bf7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A   2
GLY A  40
 None
None
ZN  A 413 ( 4.7A)
None
None
 0.87A 3q95B-4bf7A:
undetectable		 3q95B-4bf7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A   2
GLY A 331
 None
None
ZN  A 413 ( 4.7A)
None
None
 0.77A 3q95B-4bf7A:
undetectable		 3q95B-4bf7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 7 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 GOL  A1343 ( 3.5A)
GOL  A1343 ( 4.6A)
None
None
 1.11A 3s3gA-4bf7A:
2.3		 3s3gA-4bf7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 8 ASP A 332
GLY A  40
GLN A 274
GLU A 275
 ZN  A 401 (-2.9A)
None
None
ZN  A 401 (-2.2A)
 0.79A 3s3mA-4bf7A:
undetectable		 3s3mA-4bf7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 8 ASP A 332
GLY A  40
GLN A 274
GLU A 275
 ZN  A 401 (-2.9A)
None
None
ZN  A 401 (-2.2A)
 0.75A 3s3nA-4bf7A:
undetectable		 3s3nA-4bf7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 8 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 GOL  A1343 ( 3.5A)
GOL  A1343 ( 4.6A)
None
None
 1.01A 3v35A-4bf7A:
12.5		 3v35A-4bf7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 8 ILE A 154
PRO A  95
VAL A 110
TRP A  98
 None
 1.31A 4f4dB-4bf7A:
undetectable		 4f4dB-4bf7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 6 ASP A 187
ASP A 185
ASN A 182
ALA A 222
 ACT  A1340 (-3.1A)
ZN  A 412 ( 2.2A)
ACT  A1338 (-3.2A)
None
 1.19A 4mdaA-4bf7A:
undetectable		 4mdaA-4bf7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 GLY A 134
VAL A 212
ARG A  45
ILE A 154
VAL A 196
 None
None
GOL  A1343 ( 4.2A)
None
None
 1.32A 4okwA-4bf7A:
undetectable		 4okwA-4bf7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A   2
GLY A  40
 None
None
ZN  A 413 ( 4.7A)
None
None
 0.90A 4pxmA-4bf7A:
undetectable		 4pxmA-4bf7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A   2
GLY A 331
 None
None
ZN  A 413 ( 4.7A)
None
None
 0.78A 4pxmA-4bf7A:
undetectable		 4pxmA-4bf7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 ALA A 334
THR A 247
ARG A   5
VAL A 244
LEU A   2
 None
 1.34A 4qzuA-4bf7A:
undetectable		 4qzuA-4bf7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 4 TYR A 151
THR A 148
GLY A 140
LEU A 180
 None
 1.02A 4w5nA-4bf7A:
2.6		 4w5nA-4bf7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 9 LEU A  80
SER A 168
LEU A 115
VAL A 117
THR A 114
 None
 1.23A 4x3mB-4bf7A:
2.3		 4x3mB-4bf7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 6 ASN A 153
ASP A 149
THR A 199
THR A 201
 ZN  A 404 ( 4.3A)
None
None
IMD  A1342 (-4.1A)
 0.94A 4yoaA-4bf7A:
undetectable		 4yoaA-4bf7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 4 VAL A 128
ALA A 127
ASN A 125
GLN A  70
 None
 1.47A 4zgfA-4bf7A:
undetectable		 4zgfA-4bf7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		6 / 12 TYR A 294
VAL A  41
LEU A  36
ILE A  48
SER A  11
ILE A  44
 None
 1.38A 5hbsA-4bf7A:
undetectable		 5hbsA-4bf7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 9 ILE A   9
PRO A 298
MET A 315
ILE A 293
LEU A  65
 None
 1.49A 5iepA-4bf7A:
undetectable		 5iepA-4bf7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 6 ASP A  79
HIS A  81
ILE A 137
TYR A 215
 None
GOL  A1343 ( 4.6A)
None
ACT  A1336 (-4.0A)
 1.03A 5ih0A-4bf7A:
undetectable		 5ih0A-4bf7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		5 / 12 LEU A 177
HIS A 179
ARG A  45
ILE A  44
ASP A   8
 None
None
GOL  A1343 ( 4.2A)
None
None
 1.43A 6bxnA-4bf7A:
undetectable		 6bxnA-4bf7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A
(Aspergillus
nidulans) 		4 / 6 ILE A  44
LEU A  12
VAL A  69
ARG A  68
 None
None
None
ACT  A1337 ( 3.8A)
 1.21A 6f6jA-4bf7A:
undetectable		 6f6jA-4bf7A:
undetectable