SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4
(Mus
musculus) 		4 / 8 LEU A  45
GLU A 106
THR A  59
ALA A  61
 None
 0.73A 1sn5C-4bfeA:
3.0		 1sn5C-4bfeA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4
(Mus
musculus) 		4 / 6 SER A 188
PRO A 155
SER A 201
VAL A 186
 None
 1.06A 2hdnI-4bfeA:
undetectable
2hdnJ-4bfeA:
undetectable
2hdnL-4bfeA:
undetectable		 2hdnI-4bfeA:
12.72
2hdnJ-4bfeA:
19.94
2hdnL-4bfeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4
(Mus
musculus) 		4 / 6 SER A 201
VAL A 186
SER A 188
PRO A 155
 None
 1.25A 2hdnJ-4bfeA:
undetectable
2hdnK-4bfeA:
undetectable
2hdnL-4bfeA:
undetectable		 2hdnJ-4bfeA:
19.94
2hdnK-4bfeA:
12.72
2hdnL-4bfeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4
(Mus
musculus) 		4 / 8 TYR A  62
ASN A  63
LYS A  67
LYS A  66
 NAG  A 690 (-4.9A)
None
None
None
 1.25A 3bjwD-4bfeA:
undetectable		 3bjwD-4bfeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4bfe CELL SURFACE
GLYCOPROTEIN CD200
RECEPTOR 4
(Mus
musculus) 		4 / 5 ARG A  76
ILE A  50
TYR A 103
THR A 104
 None
 1.33A 3dgqA-4bfeA:
undetectable		 3dgqA-4bfeA:
19.09