SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 11 GLU A 981
ARG A 977
LEU A1032
ALA A 983
GLY A 901
None
1.26A 1cmaA-4bfrA:
undetectable
1cmaB-4bfrA:
undetectable
1cmaA-4bfrA:
7.47
1cmaB-4bfrA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 10 GLU A 981
ARG A 977
LEU A1032
ALA A 983
GLY A 901
None
1.29A 1cmcA-4bfrA:
undetectable
1cmcB-4bfrA:
undetectable
1cmcA-4bfrA:
7.47
1cmcB-4bfrA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 GLU A 180
LEU A 179
VAL A 267
MET A 268
None
1.05A 1hk1A-4bfrA:
undetectable
1hk1A-4bfrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 GLU A 180
LEU A 179
VAL A 267
MET A 268
None
1.01A 1hk3A-4bfrA:
1.2
1hk3A-4bfrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 GLU A1008
HIS A 934
ASP A 807
None
None
J82  A2000 ( 4.9A)
0.79A 1i9gA-4bfrA:
undetectable
1i9gA-4bfrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 8 ASP A 827
ASP A 818
GLY A 901
THR A 924
None
0.76A 1m4iA-4bfrA:
undetectable
1m4iA-4bfrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 11 ILE A 574
PRO A 389
LEU A 358
TYR A 642
ASP A 605
None
1.24A 1mrlA-4bfrA:
undetectable
1mrlB-4bfrA:
undetectable
1mrlA-4bfrA:
12.55
1mrlB-4bfrA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 LEU A 927
PHE A 952
SER A 906
ILE A 911
ILE A 919
None
1.36A 1osvB-4bfrA:
undetectable
1osvB-4bfrA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 10 LEU A1002
MET A1001
LEU A1000
MET A 813
LEU A 936
None
1.46A 1qkuC-4bfrA:
undetectable
1qkuC-4bfrA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
6 / 12 LEU A 909
GLY A 933
ASP A 913
ILE A 930
ALA A 905
ILE A 911
None
None
None
J82  A2000 (-3.6A)
None
None
1.44A 1rl8B-4bfrA:
undetectable
1rl8B-4bfrA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ASN A 468
LEU A 463
TRP A 434
PHE A 459
None
1.32A 1ru9H-4bfrA:
undetectable
1ru9L-4bfrA:
3.1
1ru9H-4bfrA:
12.85
1ru9L-4bfrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ASN A 468
LEU A 463
TRP A 434
PHE A 459
None
1.33A 1rukH-4bfrA:
3.1
1rukL-4bfrA:
undetectable
1rukH-4bfrA:
12.85
1rukL-4bfrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 LEU A 567
LEU A 570
SER A 573
None
0.64A 1tlmA-4bfrA:
2.7
1tlmA-4bfrA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
None
1.13A 1wsvA-4bfrA:
undetectable
1wsvA-4bfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
None
1.08A 1wsvB-4bfrA:
undetectable
1wsvB-4bfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 8 GLY A 839
THR A 838
ALA A 837
VAL A 637
None
0.88A 2a1hA-4bfrA:
undetectable
2a1hB-4bfrA:
undetectable
2a1hA-4bfrA:
17.85
2a1hB-4bfrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 5 LEU A 828
PHE A 976
VAL A 904
ALA A 983
None
1.20A 2cizA-4bfrA:
undetectable
2cizA-4bfrA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 11 LEU A 936
LEU A 909
PRO A 540
ASN A 992
LEU A1006
None
1.23A 2ft9A-4bfrA:
undetectable
2ft9A-4bfrA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 LYS A 569
TYR A 608
PRO A 568
None
1.46A 2j9cC-4bfrA:
undetectable
2j9cC-4bfrA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 5 ALA A 583
ASP A 387
ASP A 382
ASP A 581
None
0.97A 2nyuB-4bfrA:
undetectable
2nyuB-4bfrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 10 ILE A 962
ALA A 900
PHE A 895
ILE A 854
LEU A 875
None
1.13A 2w3aB-4bfrA:
undetectable
2w3aB-4bfrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ASP A 605
TYR A 642
PHE A 998
LEU A1009
None
1.19A 2w98A-4bfrA:
undetectable
2w98B-4bfrA:
undetectable
2w98A-4bfrA:
16.08
2w98B-4bfrA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 TRP A 434
VAL A 432
TRP A 456
None
1.31A 2y6nC-4bfrA:
undetectable
2y6nD-4bfrA:
undetectable
2y6nC-4bfrA:
1.45
2y6nD-4bfrA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 TRP A 434
VAL A 432
TRP A 456
None
1.34A 2y6nE-4bfrA:
undetectable
2y6nF-4bfrA:
undetectable
2y6nE-4bfrA:
1.45
2y6nF-4bfrA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 LEU A 257
ILE A 215
PHE A 197
VAL A 195
VAL A 193
None
1.17A 2ygpA-4bfrA:
undetectable
2ygpA-4bfrA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 8 ALA A 735
TYR A 772
HIS A 737
ILE A 720
None
0.88A 2zm9A-4bfrA:
undetectable
2zm9A-4bfrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ILE A 919
ILE A 935
LEU A 927
PHE A 928
None
0.78A 3adsA-4bfrA:
undetectable
3adsA-4bfrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 ILE A 919
LEU A 927
PHE A 928
LEU A 811
None
0.94A 3adxA-4bfrA:
undetectable
3adxA-4bfrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 ILE A 329
LEU A 379
PHE A 381
ARG A 393
None
1.04A 3ag4N-4bfrA:
undetectable
3ag4W-4bfrA:
undetectable
3ag4N-4bfrA:
18.38
3ag4W-4bfrA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 LEU A1009
LEU A1002
LEU A1000
MET A 813
LEU A 936
None
1.17A 3erdA-4bfrA:
undetectable
3erdA-4bfrA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 GLU A 249
ARG A 247
VAL A 193
ILE A 263
ASN A 265
None
1.35A 3jb3A-4bfrA:
undetectable
3jb3A-4bfrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 LEU A 816
LEU A 819
GLU A 823
GLY A 991
LEU A 987
None
1.13A 3olsA-4bfrA:
undetectable
3olsA-4bfrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 MET A 813
LEU A 816
LEU A 819
GLU A 823
GLY A 991
None
0.93A 3olsA-4bfrA:
undetectable
3olsA-4bfrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 8 PHE A1039
PHE A1035
PHE A 952
ALA A 900
THR A 896
None
1.49A 3t3sD-4bfrA:
undetectable
3t3sD-4bfrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 LEU A 740
HIS A 737
MET A 736
None
0.87A 3thrD-4bfrA:
2.1
3thrD-4bfrA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 10 LEU A1002
MET A1001
LEU A1000
MET A 813
LEU A 936
None
1.38A 3uudB-4bfrA:
undetectable
3uudB-4bfrA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 7 VAL A 208
PHE A 206
VAL A 195
PHE A 275
ILE A 263
None
1.47A 3zjqA-4bfrA:
undetectable
3zjqA-4bfrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 7 VAL A 208
PHE A 206
VAL A 195
PHE A 275
ILE A 263
None
1.45A 3zjqB-4bfrA:
undetectable
3zjqB-4bfrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 8 VAL A 921
TYR A 902
CYH A 899
ILE A 919
None
1.29A 4bqtC-4bfrA:
undetectable
4bqtD-4bfrA:
undetectable
4bqtC-4bfrA:
13.86
4bqtD-4bfrA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 LYS A1050
THR A 955
ILE A 962
None
0.83A 4e0fB-4bfrA:
undetectable
4e0fB-4bfrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ILE A 911
ARG A 914
ILE A 930
LEU A 811
None
None
J82  A2000 (-3.6A)
None
0.99A 4m51A-4bfrA:
undetectable
4m51A-4bfrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 5 GLY A 974
ILE A 962
LEU A 954
LEU A1032
None
0.78A 4o8fA-4bfrA:
undetectable
4o8fA-4bfrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 ASN A 577
ASP A 581
ASP A 550
None
0.76A 4obwD-4bfrA:
undetectable
4obwD-4bfrA:
14.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 ILE A 845
VAL A 848
THR A 853
MET A 920
ILE A 930
J82  A2000 ( 4.4A)
J82  A2000 (-3.8A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
1.08A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
ASP A 856
ASP A 931
J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
J82  A2000 (-4.9A)
1.02A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
ASP A 856
ILE A 930
J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
J82  A2000 (-3.6A)
1.05A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
TYR A 833
ILE A 930
J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
J82  A2000 (-3.6A)
0.90A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
6 / 12 PRO A 779
TRP A 781
ILE A 797
ASP A 856
THR A 853
ASP A 931
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
None
J82  A2000 (-4.9A)
1.40A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
7 / 12 PRO A 779
TRP A 781
ILE A 797
ASP A 856
THR A 853
MET A 920
ILE A 930
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
1.28A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
7 / 12 PRO A 779
TRP A 781
ILE A 797
TYR A 833
THR A 853
MET A 920
ILE A 930
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
0.79A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
7 / 12 TRP A 781
ILE A 797
TYR A 833
VAL A 848
THR A 853
MET A 920
ILE A 930
None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
J82  A2000 (-3.8A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
0.75A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 12 TYR A 833
VAL A 847
THR A 853
MET A 920
ILE A 930
J82  A2000 (-3.7A)
J82  A2000 (-3.7A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
1.38A 4xe0A-4bfrA:
40.7
4xe0A-4bfrA:
57.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ILE A 329
LEU A 379
PHE A 381
ARG A 393
None
1.07A 5b1aN-4bfrA:
undetectable
5b1aW-4bfrA:
undetectable
5b1aN-4bfrA:
18.38
5b1aW-4bfrA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 ILE A 329
PHE A 489
ARG A 393
LEU A 388
None
0.92A 5b1bN-4bfrA:
undetectable
5b1bW-4bfrA:
undetectable
5b1bN-4bfrA:
18.38
5b1bW-4bfrA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 7 ALA A 905
ASP A 827
ARG A 829
THR A 924
GLU A 894
None
1.17A 5bs8A-4bfrA:
undetectable
5bs8C-4bfrA:
undetectable
5bs8D-4bfrA:
undetectable
5bs8A-4bfrA:
18.11
5bs8C-4bfrA:
18.11
5bs8D-4bfrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 ASP A 827
ARG A 829
THR A 924
GLU A 894
None
0.95A 5btaA-4bfrA:
undetectable
5btaC-4bfrA:
undetectable
5btaD-4bfrA:
undetectable
5btaA-4bfrA:
18.21
5btaC-4bfrA:
18.21
5btaD-4bfrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 7 ASP A 827
ARG A 829
THR A 924
GLU A 894
None
0.98A 5btfA-4bfrA:
1.4
5btfB-4bfrA:
undetectable
5btfC-4bfrA:
1.4
5btfA-4bfrA:
18.21
5btfB-4bfrA:
15.20
5btfC-4bfrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
3 / 3 GLU A1008
HIS A 934
ASP A 807
None
None
J82  A2000 ( 4.9A)
0.72A 5c0oG-4bfrA:
undetectable
5c0oG-4bfrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 6 ALA A 482
THR A 483
VAL A 435
HIS A 454
None
1.03A 5eclA-4bfrA:
undetectable
5eclA-4bfrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 11 LEU A1002
MET A1001
LEU A1000
MET A 813
LEU A 936
None
1.42A 5hyrB-4bfrA:
undetectable
5hyrB-4bfrA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 4 LEU A 997
MET A 817
ILE A1015
LEU A 909
None
1.29A 5nfpA-4bfrA:
undetectable
5nfpA-4bfrA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
5 / 10 LEU A1002
MET A1001
LEU A1000
MET A 813
LEU A 936
None
1.40A 5wgqB-4bfrA:
1.8
5wgqB-4bfrA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus
musculus)
4 / 5 VAL A 439
LEU A 351
VAL A 362
LEU A 467
None
0.94A 6bqgA-4bfrA:
undetectable
6bqgA-4bfrA:
6.31