SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 4 ILE A 100
LEU A 103
VAL A 107
ALA A 116
 None
 0.87A 1mz9A-4bg5A:
undetectable		 1mz9A-4bg5A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 5 ILE A 100
LEU A 103
VAL A 107
ALA A 116
 None
 0.85A 1mz9C-4bg5A:
undetectable		 1mz9C-4bg5A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 10 LEU A 227
LEU A 224
ILE A 160
GLU A 173
LEU A 167
 None
 1.07A 1wopA-4bg5A:
undetectable		 1wopA-4bg5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 11 LEU A 224
ALA A 136
LEU A 140
ASN A 143
MET A 144
 None
 1.07A 3e22B-4bg5A:
undetectable		 3e22B-4bg5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 11 LEU A 224
ALA A 136
LEU A 140
ASN A 143
MET A 144
 None
 1.06A 3e22D-4bg5A:
undetectable		 3e22D-4bg5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 10 ILE A 120
ILE A 123
GLY A 126
TYR A  90
LEU A  58
 None
 1.22A 3elzB-4bg5A:
undetectable		 3elzB-4bg5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 10 ILE A 120
ILE A 123
GLY A 126
TYR A  90
LEU A  58
 None
 1.17A 3elzC-4bg5A:
undetectable		 3elzC-4bg5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 8 ASN A 199
VAL A 107
HIS A 117
ILE A 120
 None
 1.00A 4eyzA-4bg5A:
undetectable		 4eyzA-4bg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 8 ASN A 199
VAL A 107
HIS A 117
ILE A 120
 None
 0.99A 4eyzB-4bg5A:
undetectable		 4eyzB-4bg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 6 ILE A  44
TYR A  90
TYR A  95
PHE A  48
 None
 1.16A 4g10A-4bg5A:
undetectable		 4g10A-4bg5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4bg5 BBA65
(Borreliella
burgdorferi) 		5 / 12 LEU A 224
ALA A 136
LEU A 140
ASN A 143
MET A 144
 None
 1.24A 4x1iB-4bg5A:
undetectable		 4x1iB-4bg5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4bg5 BBA65
(Borreliella
burgdorferi) 		4 / 5 LEU A  24
GLU A  26
MET A  32
LEU A 137
 None
 1.15A 4xi3B-4bg5A:
undetectable		 4xi3B-4bg5A:
19.26