SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 258
ILE A 260
ASN A 256
ILE A 255
 None
 1.09A 2h4jA-4bgfA:
undetectable		 2h4jA-4bgfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 249
ALA A 211
ALA A 210
VAL A 246
HIS A  73
 None
 1.26A 3bszE-4bgfA:
undetectable		 3bszE-4bgfA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		6 / 6 PHE A  38
TYR A  69
CYH A  70
VAL A  95
THR A 109
PHE A 204
 None
 0.29A 3ltwA-4bgfA:
44.2		 3ltwA-4bgfA:
74.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.81A 3ltwA-4bgfA:
44.2		 3ltwA-4bgfA:
74.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 211
PRO A  37
GLY A 129
GLY A  68
LEU A 112
 None
 1.02A 5c0oH-4bgfA:
undetectable		 5c0oH-4bgfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		4 / 5 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.10A 5c0oH-4bgfA:
undetectable		 5c0oH-4bgfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  52
ASP A  50
ALA A 196
SER A 202
PRO A 107
 None
 1.33A 5hnzB-4bgfA:
undetectable		 5hnzB-4bgfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 127
THR A 134
VAL A  95
TYR A 177
 None
 1.10A 5ov9A-4bgfA:
undetectable		 5ov9A-4bgfA:
20.65