SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 GLU A  97
ALA A 104
SER A 108
HIS A 126
 None
 1.04A 1errA-4bgoA:
undetectable
1errB-4bgoA:
undetectable		 1errA-4bgoA:
22.80
1errB-4bgoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		5 / 12 ARG A  86
THR A 137
GLN A 141
LEU A 148
ILE A 144
 None
 1.45A 2fj1A-4bgoA:
undetectable		 2fj1A-4bgoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		5 / 11 LEU A 271
GLU A 273
GLY A 266
LEU A 275
SER A 276
 None
 1.01A 2qmmA-4bgoA:
undetectable
2qmmB-4bgoA:
undetectable		 2qmmA-4bgoA:
20.72
2qmmB-4bgoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		3 / 3 ARG A 127
THR A 195
THR A  63
 None
 0.53A 3k2hB-4bgoA:
undetectable		 3k2hB-4bgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		3 / 3 PHE A 164
TYR A  51
LEU A  39
 None
 0.79A 3keeB-4bgoA:
undetectable		 3keeB-4bgoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 ILE A 185
PHE A 200
ASP A 199
GLU A 189
 None
 1.04A 3kp6A-4bgoA:
1.7
3kp6B-4bgoA:
undetectable		 3kp6A-4bgoA:
20.77
3kp6B-4bgoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		5 / 12 GLY A 280
LEU A 213
ASP A  47
GLY A  43
PRO A 216
 None
 1.00A 4fzvA-4bgoA:
undetectable		 4fzvA-4bgoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 6 GLU A 188
ASP A 190
ASP A 199
GLU A  90
 None
 1.09A 4ntxA-4bgoA:
undetectable
4ntxC-4bgoA:
undetectable		 4ntxA-4bgoA:
22.68
4ntxC-4bgoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.03A 4w5oA-4bgoA:
undetectable		 4w5oA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.01A 4z4cA-4bgoA:
undetectable		 4z4cA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.03A 4z4dA-4bgoA:
undetectable		 4z4dA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 5 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.01A 4z4eA-4bgoA:
undetectable		 4z4eA-4bgoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4bgo EFEM M75 PEPTIDASE
(Pseudomonas
syringae) 		4 / 6 PHE A 164
PRO A 166
VAL A 169
PHE A 214
 None
 1.02A 5t7bA-4bgoA:
undetectable		 5t7bA-4bgoA:
16.51