SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		5 / 12 ALA A 157
ILE A 120
THR A 288
LEU A 287
LEU A 160
 None
 1.36A 1eiiA-4bgqA:
undetectable		 1eiiA-4bgqA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 5 LYS A  94
LEU A  99
GLU A  93
LEU A 100
 None
 1.15A 1eta1-4bgqA:
undetectable		 1eta1-4bgqA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 5 LYS A  94
LEU A  99
GLU A  93
LEU A 100
 None
 1.14A 1eta2-4bgqA:
undetectable		 1eta2-4bgqA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 LYS A  94
LEU A  99
GLU A  93
LEU A 100
 None
 1.15A 1etb1-4bgqA:
undetectable		 1etb1-4bgqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 PHE A 297
VAL A 197
GLY A 198
VAL A 112
 None
 1.00A 1t88A-4bgqA:
undetectable		 1t88A-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 8 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.11A 1uyuB-4bgqA:
undetectable		 1uyuB-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 LEU A 292
HIS A 124
LYS A 121
 None
ACT  A1004 (-3.8A)
None
 1.03A 1y7iA-4bgqA:
undetectable		 1y7iA-4bgqA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 12 VAL A  27
LYS A  42
VAL A  73
PHE A  89
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 2eufB-4bgqA:
30.6		 2eufB-4bgqA:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 11 VAL A  19
GLY A  20
VAL A  27
ALA A  40
TYR A  91
LEU A 142
 38R  A1000 (-4.7A)
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
 0.47A 2evaA-4bgqA:
23.4		 2evaA-4bgqA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.06A 2feuA-4bgqA:
undetectable		 2feuA-4bgqA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 LEU A 204
LEU A 273
TYR A 177
MET A 274
 None
 1.20A 2w8yA-4bgqA:
undetectable		 2w8yA-4bgqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 LEU A 287
THR A 288
LEU A 277
ASP A 284
 None
 1.09A 2wm3A-4bgqA:
undetectable		 2wm3A-4bgqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.01A 3fwfB-4bgqA:
undetectable		 3fwfB-4bgqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.07A 3fwgA-4bgqA:
undetectable		 3fwgA-4bgqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 PRO A 229
LEU A 230
GLN A 224
 None
 0.72A 3hznG-4bgqA:
undetectable
3hznH-4bgqA:
undetectable		 3hznG-4bgqA:
21.16
3hznH-4bgqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.00A 3l63A-4bgqA:
undetectable		 3l63A-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
TYR A  91
VAL A  92
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.58A 3lxnA-4bgqA:
23.7		 3lxnA-4bgqA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.05A 3wrhE-4bgqA:
undetectable		 3wrhE-4bgqA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.07A 3wrjE-4bgqA:
undetectable		 3wrjE-4bgqA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.03A 3wrlE-4bgqA:
undetectable		 3wrlE-4bgqA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 ALA A  40
LYS A  42
LEU A  64
ILE A  72
HIS A 133
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
None
None
None
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 1.06A 4c8bB-4bgqA:
22.4		 4c8bB-4bgqA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.04A 4ek1A-4bgqA:
undetectable		 4ek1A-4bgqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.07A 4g3rA-4bgqA:
undetectable		 4g3rA-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.10A 4g3rB-4bgqA:
undetectable		 4g3rB-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 MET A 274
ARG A 261
TRP A 195
PHE A 211
 None
 1.39A 4jseA-4bgqA:
undetectable
4jseB-4bgqA:
undetectable		 4jseA-4bgqA:
21.41
4jseB-4bgqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 TRP A 195
PHE A 211
MET A 274
ARG A 261
 None
 1.39A 4jseA-4bgqA:
undetectable
4jseB-4bgqA:
undetectable		 4jseA-4bgqA:
21.41
4jseB-4bgqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 5 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.10A 4l49A-4bgqA:
undetectable		 4l49A-4bgqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 6 PHE A 297
LEU A 277
VAL A 197
VAL A 112
 None
 1.06A 4l4cA-4bgqA:
undetectable		 4l4cA-4bgqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 None
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
 0.44A 5j5xA-4bgqA:
25.2		 5j5xA-4bgqA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 GLY A  20
TYR A  24
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 (-3.6A)
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.85A 5l2iA-4bgqA:
16.7		 5l2iA-4bgqA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.68A 5l2tA-4bgqA:
17.1		 5l2tA-4bgqA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 10 VAL A  27
ALA A  40
VAL A  73
TYR A  91
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 5n3hA-4bgqA:
25.6		 5n3hA-4bgqA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 4 VAL A  27
LYS A  42
VAL A  73
ASN A 140
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
None
 0.99A 5vc3A-4bgqA:
26.3		 5vc3A-4bgqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		5 / 12 VAL A  73
GLU A  77
PHE A  13
THR A  35
HIS A  32
 None
 1.48A 5xipB-4bgqA:
undetectable		 5xipB-4bgqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 LYS A  42
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2A-4bgqA:
17.1		 5zv2A-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 TYR A  91
LEU A 142
ASP A 153
 38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2B-4bgqA:
17.6		 5zv2B-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		5 / 12 ILE A 123
SER A 196
LEU A  67
ILE A 200
LEU A 141
 None
 1.11A 6dwnC-4bgqA:
undetectable		 6dwnC-4bgqA:
13.99