SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bgu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 9 GLY A   8
ASP A  34
ILE A  35
ALA A  79
ILE A  99
 None
None
CL  A1316 ( 3.9A)
None
None
 0.70A 1cetA-4bguA:
38.4		 1cetA-4bguA:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 9 GLY A   8
ASP A  34
TYR A  66
ALA A  79
ILE A  99
 None
 0.83A 1cetA-4bguA:
38.4		 1cetA-4bguA:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 5 HIS A 139
GLU A 254
ALA A 261
SER A 248
 None
 1.35A 1errA-4bguA:
undetectable
1errB-4bguA:
undetectable		 1errA-4bguA:
21.97
1errB-4bguA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A 143
PHE A 144
SER A 150
ILE A 142
LEU A 268
 None
 1.04A 1lhuA-4bguA:
undetectable		 1lhuA-4bguA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 9 GLY A 225
GLY A 229
GLY A 145
GLY A 146
ASP A 149
 None
 1.01A 1mxdA-4bguA:
undetectable		 1mxdA-4bguA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 11 GLY A 225
GLY A 229
GLY A 145
GLY A 146
ASP A 149
 None
 0.98A 1mxgA-4bguA:
undetectable		 1mxgA-4bguA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 11 ARG A 152
THR A 222
GLY A 220
GLU A 217
MET A 213
 CL  A1321 (-2.9A)
CL  A1321 (-3.5A)
None
None
CL  A1338 ( 4.6A)
 1.34A 1odiE-4bguA:
2.1		 1odiE-4bguA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 11 ARG A 152
THR A 222
GLY A 220
GLU A 217
MET A 213
 CL  A1321 (-2.9A)
CL  A1321 (-3.5A)
None
None
CL  A1338 ( 4.6A)
 1.39A 1odiF-4bguA:
2.3		 1odiF-4bguA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 8 ASP A 124
ARG A 138
LEU A 251
GLU A 254
 None
 0.92A 2cdqA-4bguA:
undetectable		 2cdqA-4bguA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 7 ASP A 124
ARG A 138
LEU A 251
GLU A 254
 None
 0.91A 2cdqB-4bguA:
2.0		 2cdqB-4bguA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 ILE A  53
LEU A  30
PHE A  32
GLN A  45
ALA A  15
 None
 1.41A 2noaA-4bguA:
2.2		 2noaA-4bguA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		6 / 12 GLY A 145
GLY A 174
GLY A 247
LEU A 288
PHE A 184
ASP A 149
 None
 1.49A 3elwA-4bguA:
4.6		 3elwA-4bguA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A 145
GLY A 174
GLY A 247
LEU A 288
ASP A 149
 None
 1.06A 3gczA-4bguA:
4.7		 3gczA-4bguA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A  18
ALA A  17
GLY A   8
ILE A   7
VAL A 230
 None
 1.03A 3gguA-4bguA:
undetectable		 3gguA-4bguA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 MET A 100
GLN A  87
LEU A 125
THR A 118
ILE A  77
 None
 1.42A 3mneA-4bguA:
undetectable		 3mneA-4bguA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 8 ALA A 231
ASN A  20
ALA A  22
THR A  59
 None
CL  A1326 (-3.0A)
None
None
 0.80A 3t3sD-4bguA:
undetectable		 3t3sD-4bguA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 8 ALA A 231
ASN A  20
ALA A  22
THR A  59
 None
CL  A1326 (-3.0A)
None
None
 0.96A 3t3sF-4bguA:
undetectable		 3t3sF-4bguA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 9 GLY A  18
ALA A  17
GLY A   8
ILE A   7
VAL A 230
 None
 1.05A 3u7sB-4bguA:
undetectable		 3u7sB-4bguA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 SER A   5
GLY A   8
ALA A  79
SER A 106
PHE A 114
 None
 1.00A 4bupB-4bguA:
undetectable		 4bupB-4bguA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 9 ASP A  34
TYR A  66
ALA A  79
ILE A  99
ILE A 103
 None
 0.63A 4oknB-4bguA:
40.0		 4oknB-4bguA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 6 ASP A 124
ALA A 292
LYS A 295
THR A 260
 None
None
CL  A1318 (-3.3A)
None
 1.46A 4w5qA-4bguA:
undetectable		 4w5qA-4bguA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 LEU A  30
VAL A   6
ALA A  10
ALA A   9
GLY A   8
 None
 1.21A 5tzoB-4bguA:
undetectable		 5tzoB-4bguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A  18
ALA A  17
GLY A   8
ILE A   7
VAL A 230
 None
 0.90A 6dh0B-4bguA:
undetectable		 6dh0B-4bguA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 5 GLN A  45
THR A  42
THR A  69
GLY A  14
 None
 1.14A 6gbnC-4bguA:
6.3		 6gbnC-4bguA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A  11
GLY A  14
VAL A   6
VAL A 230
PRO A 226
 None
 1.15A 6gneA-4bguA:
5.1		 6gneA-4bguA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 GLY A  11
GLY A  14
VAL A   6
VAL A 230
PRO A 226
 None
 1.15A 6gneB-4bguA:
5.0		 6gneB-4bguA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		5 / 12 ILE A   7
GLY A   8
GLY A  11
ALA A  16
ILE A  35
 None
None
None
None
CL  A1316 ( 3.9A)
 0.81A 6iftA-4bguA:
3.3		 6iftA-4bguA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 7 ASP A 137
ARG A 138
TYR A 131
ASP A 252
 CL  A1324 (-3.9A)
None
PGE  A1341 ( 3.9A)
None
 0.90A 6mn5B-4bguA:
undetectable		 6mn5B-4bguA:
16.33