SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		6 / 9 GLY A  10
ASP A  34
ILE A  35
TYR A  71
ALA A  84
ILE A 104
 None
 0.81A 1cetA-4bgvA:
41.6		 1cetA-4bgvA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 11 PRO A 235
THR A  17
GLY A  15
THR A  83
VAL A 124
 None
 1.34A 2uvnB-4bgvA:
undetectable		 2uvnB-4bgvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 PHE A 217
GLY A 218
PHE A 158
VAL A 223
SER A 230
 None
None
None
None
PEG  A1325 (-3.4A)
 1.39A 3dh0A-4bgvA:
7.6		 3dh0A-4bgvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 VAL A  81
ILE A   6
VAL A   8
LEU A  22
THR A  21
 None
 0.87A 3fw3A-4bgvA:
undetectable		 3fw3A-4bgvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 VAL A  81
ILE A   6
VAL A   8
LEU A  22
THR A  21
 None
 0.84A 3fw3B-4bgvA:
undetectable		 3fw3B-4bgvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 ALA A 257
LEU A 149
GLY A 180
PRO A 127
LEU A  98
 None
 1.34A 3tm4A-4bgvA:
9.4		 3tm4A-4bgvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 8 VAL A 108
TYR A 115
ILE A 135
ILE A  80
 None
 1.00A 4afgD-4bgvA:
undetectable
4afgE-4bgvA:
undetectable		 4afgD-4bgvA:
22.85
4afgE-4bgvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 8 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.77A 4fglD-4bgvA:
5.0		 4fglD-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 7 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.91A 4fglC-4bgvA:
5.1		 4fglC-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 8 ASN A 323
ASP A  96
LEU A  99
ASP A 318
ILE A 315
 None
 1.40A 4k0bA-4bgvA:
undetectable		 4k0bA-4bgvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 5 LEU A 203
PRO A 204
ILE A 211
ARG A 214
 None
 1.04A 4klrA-4bgvA:
3.4		 4klrA-4bgvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 8 ASN A 323
ASP A  96
LEU A  99
ASP A 318
ILE A 315
 None
 1.36A 4l7iA-4bgvA:
undetectable		 4l7iA-4bgvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		6 / 12 TYR A  71
GLY A  62
ILE A  30
SER A   7
MET A  74
ALA A  40
 None
 1.36A 4qtuD-4bgvA:
6.8		 4qtuD-4bgvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 5 ILE A   9
ILE A  35
TYR A  71
GLU A  68
 None
 1.13A 4zzcE-4bgvA:
undetectable		 4zzcE-4bgvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 ALA A 258
VAL A 286
GLY A 151
PHE A 188
TYR A 191
 None
 1.09A 5igiA-4bgvA:
undetectable		 5igiA-4bgvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		3 / 3 SER A  77
SER A 119
PHE A  33
 None
 0.70A 5mugA-4bgvA:
undetectable		 5mugA-4bgvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		4 / 7 ASP A 184
ASP A 129
TRP A 302
GLY A 276
 None
 0.80A 5x7pA-4bgvA:
undetectable		 5x7pA-4bgvA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4bgv MALATE DEHYDROGENASE
(Picrophilus
torridus) 		5 / 12 PRO A 255
ILE A 279
VAL A 253
ILE A 275
VAL A 286
 None
 1.42A 6j21A-4bgvA:
undetectable		 6j21A-4bgvA:
21.34