SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		5 / 12 ILE A 386
ALA A 344
LEU A 365
SER A 392
LEU A 400
 None
None
None
IOD  A1421 ( 4.9A)
None
 1.20A 1ddsB-4bh5A:
undetectable		 1ddsB-4bh5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		4 / 6 ARG A 303
GLU A 332
PRO A 385
ALA A 335
 None
 1.46A 2ejfB-4bh5A:
undetectable		 2ejfB-4bh5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		4 / 8 GLN A 395
SER A 399
TYR A 401
TRP A 320
 None
 1.34A 2xz5A-4bh5A:
undetectable
2xz5C-4bh5A:
undetectable		 2xz5A-4bh5A:
21.62
2xz5C-4bh5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		4 / 7 GLN A 395
SER A 399
TYR A 401
TRP A 320
 None
 1.36A 2xz5D-4bh5A:
undetectable
2xz5E-4bh5A:
undetectable		 2xz5D-4bh5A:
21.62
2xz5E-4bh5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		3 / 3 ARG A 405
TYR A 401
GLU A 403
 IOD  A1420 ( 4.6A)
None
None
 0.70A 4zzbE-4bh5A:
undetectable		 4zzbE-4bh5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		5 / 12 VAL A 341
PHE A 402
VAL A 302
VAL A 354
HIS A 358
 None
 1.32A 6ap6A-4bh5A:
undetectable		 6ap6A-4bh5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC
(Escherichia
coli) 		5 / 12 VAL A 341
PHE A 402
VAL A 302
VAL A 354
HIS A 358
 None
 1.31A 6ap6B-4bh5A:
undetectable		 6ap6B-4bh5A:
20.82