SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 362
ALA A 348
ASP A 345
GLY A 324
 None
 1.03A 1e7bA-4bh6A:
undetectable		 1e7bA-4bh6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 435
VAL A 478
TRP A 479
 None
 1.06A 1gmkC-4bh6A:
undetectable
1gmkD-4bh6A:
undetectable		 1gmkC-4bh6A:
5.56
1gmkD-4bh6A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		3 / 4 LYS A 392
ALA A 401
MET A 433
 None
 0.73A 1hk3A-4bh6A:
undetectable		 1hk3A-4bh6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 438
SER A 436
ARG A 440
VAL A 442
 None
 1.18A 1u1jA-4bh6A:
undetectable		 1u1jA-4bh6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 363
SER A 361
GLY A 324
ARG A 369
 None
 0.86A 2j2pA-4bh6A:
undetectable
2j2pB-4bh6A:
undetectable		 2j2pA-4bh6A:
22.29
2j2pB-4bh6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 369
ASP A 363
SER A 361
GLY A 324
 None
 0.99A 2j2pA-4bh6A:
undetectable
2j2pC-4bh6A:
undetectable		 2j2pA-4bh6A:
22.29
2j2pC-4bh6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 369
ASP A 363
SER A 361
GLY A 324
 None
 1.04A 2j2pD-4bh6A:
undetectable
2j2pF-4bh6A:
undetectable		 2j2pD-4bh6A:
22.29
2j2pF-4bh6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 308
VAL A 319
GLY A 320
VAL A 347
ALA A 280
 None
 1.06A 2yy8A-4bh6A:
undetectable
2yy8B-4bh6A:
undetectable		 2yy8A-4bh6A:
21.17
2yy8B-4bh6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 419
HIS A 364
VAL A 388
GLY A 404
 None
 0.85A 3em0B-4bh6A:
undetectable		 3em0B-4bh6A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 479
VAL A 487
PHE A 545
PRO A 437
 None
 1.44A 3v35A-4bh6A:
undetectable		 3v35A-4bh6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 360
SER A 361
ALA A 348
GLU A 387
 None
 1.04A 4m93B-4bh6A:
undetectable
4m93C-4bh6A:
undetectable		 4m93B-4bh6A:
19.81
4m93C-4bh6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 495
ARG A 517
ASP A 263
VAL A 279
 None
 1.04A 4nkvB-4bh6A:
undetectable		 4nkvB-4bh6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 536
THR A 538
PHE A 516
HIS A 514
 None
 1.39A 4o4dA-4bh6A:
undetectable		 4o4dA-4bh6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
APC/C-CDH1 MODULATOR
1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 GLY A 448
THR A 449
GLY A 491
GLU I  99
 None
 1.12A 4v20A-4bh6A:
undetectable		 4v20A-4bh6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 340
ILE A 328
LEU A 350
SER A 307
 None
 0.57A 4wboB-4bh6A:
undetectable		 4wboB-4bh6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
APC/C-CDH1 MODULATOR
1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		6 / 12 GLY A 390
GLY A 446
GLY A 403
GLU I  99
ASP A 469
ILE A 474
 None
 1.37A 5e9qC-4bh6A:
undetectable		 5e9qC-4bh6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
APC/C-CDH1 MODULATOR
1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		6 / 12 GLY A 390
GLY A 446
GLY A 403
GLU I  99
ASP A 469
ILE A 474
 None
 1.35A 5eifC-4bh6A:
undetectable		 5eifC-4bh6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 281
LEU A 308
LEU A 277
HIS A 520
 None
 1.05A 5gtrA-4bh6A:
undetectable		 5gtrA-4bh6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 277
ALA A 278
LEU A 308
HIS A 297
LEU A 298
 None
 1.42A 5hyrB-4bh6A:
undetectable		 5hyrB-4bh6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 418
LYS A 417
SER A 416
 None
 0.83A 6az3P-4bh6A:
undetectable		 6az3P-4bh6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4bh6 APC/C ACTIVATOR
PROTEIN CDH1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 277
ALA A 278
LEU A 308
HIS A 297
LEU A 298
 None
 1.41A 6cbzB-4bh6A:
undetectable		 6cbzB-4bh6A:
15.62