SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TRP A 125
ALA A 129
VAL A 127
 None
 0.97A 1bdwA-4bhdA:
undetectable
1bdwB-4bhdA:
undetectable		 1bdwA-4bhdA:
3.88
1bdwB-4bhdA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 339
ARG A 388
LYS A 387
ARG A 298
ILE A  25
 None
 1.03A 1d1gA-4bhdA:
undetectable		 1d1gA-4bhdA:
16.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.87A 1dfoA-4bhdA:
47.3		 1dfoA-4bhdA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.87A 1dfoB-4bhdA:
48.3		 1dfoB-4bhdA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.86A 1dfoC-4bhdA:
48.2		 1dfoC-4bhdA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.87A 1dfoD-4bhdA:
47.4		 1dfoD-4bhdA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.85A 1eqbA-4bhdA:
47.3		 1eqbA-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
SER A 171
ARG A 363
 None
 1.08A 1eqbA-4bhdA:
47.3		 1eqbA-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		6 / 8 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
ARG A 363
 None
 0.94A 1eqbA-4bhdA:
47.3
1eqbB-4bhdA:
48.2		 1eqbA-4bhdA:
35.99
1eqbB-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.85A 1eqbB-4bhdA:
48.2		 1eqbB-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
HIS A 199
LYS A 226
ARG A 363
 None
 0.72A 1eqbA-4bhdA:
47.3
1eqbB-4bhdA:
48.2		 1eqbA-4bhdA:
35.99
1eqbB-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
 None
 0.96A 1eqbA-4bhdA:
47.3
1eqbB-4bhdA:
48.2		 1eqbA-4bhdA:
35.99
1eqbB-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.86A 1eqbC-4bhdA:
48.2		 1eqbC-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
HIS A 199
LYS A 226
ARG A 363
 None
 0.72A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
 None
 0.97A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.85A 1eqbD-4bhdA:
47.8		 1eqbD-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
HIS A 199
LYS A 226
ARG A 363
 None
 0.72A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
 None
 0.96A 1eqbC-4bhdA:
48.2
1eqbD-4bhdA:
47.8		 1eqbC-4bhdA:
35.99
1eqbD-4bhdA:
35.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 7 MET A 112
PHE A 168
ALA A 186
ILE A 158
 None
 0.95A 1fxhA-4bhdA:
undetectable
1fxhB-4bhdA:
undetectable		 1fxhA-4bhdA:
17.82
1fxhB-4bhdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.78A 1hxbA-4bhdA:
undetectable		 1hxbA-4bhdA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 204
GLY A 169
VAL A 200
ALA A 113
GLY A 222
 None
 1.14A 1kiaB-4bhdA:
3.6		 1kiaB-4bhdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 204
GLY A 169
VAL A 200
ALA A 113
GLY A 222
 None
 1.14A 1kiaC-4bhdA:
3.4		 1kiaC-4bhdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  28
GLY A 365
ARG A 363
HIS A 199
HIS A 313
 None
 1.44A 1s9aB-4bhdA:
undetectable		 1s9aB-4bhdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A 303
VAL A 302
ILE A 317
TRP A 350
 None
 1.28A 1s9qB-4bhdA:
undetectable		 1s9qB-4bhdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.84A 2avsA-4bhdA:
undetectable		 2avsA-4bhdA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.83A 2avvA-4bhdA:
undetectable		 2avvA-4bhdA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.81A 2avvD-4bhdA:
undetectable		 2avvD-4bhdA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
VAL A 100
 None
 1.49A 2fxeA-4bhdA:
undetectable		 2fxeA-4bhdA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 123
ALA A 129
GLY A 169
GLY A 120
TYR A 219
 None
 1.11A 2igtA-4bhdA:
4.3		 2igtA-4bhdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 123
ALA A 129
GLY A 169
GLY A 120
TYR A 219
 None
 1.11A 2igtB-4bhdA:
4.6		 2igtB-4bhdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  99
VAL A 100
THR A 238
HIS A  85
 None
 0.91A 2it4A-4bhdA:
undetectable		 2it4A-4bhdA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 7 SER A  30
HIS A 121
HIS A 199
LYS A 226
ARG A 363
 None
 0.69A 2vmyA-4bhdA:
49.2
2vmyB-4bhdA:
49.0		 2vmyA-4bhdA:
37.47
2vmyB-4bhdA:
37.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 119
HIS A 121
VAL A 127
SER A 171
ASN A 344
ARG A 363
 None
 1.19A 2vmyA-4bhdA:
49.2		 2vmyA-4bhdA:
37.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		6 / 8 SER A  30
HIS A 121
SER A 171
HIS A 199
LYS A 226
ARG A 363
 None
 0.95A 2vmyA-4bhdA:
49.2
2vmyB-4bhdA:
49.0		 2vmyA-4bhdA:
37.47
2vmyB-4bhdA:
37.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.87A 3cyxB-4bhdA:
undetectable		 3cyxB-4bhdA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 119
GLY A 120
VAL A 116
LEU A 348
ILE A 122
 None
 0.90A 3h52B-4bhdA:
undetectable		 3h52B-4bhdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.23A 3ko0A-4bhdA:
undetectable
3ko0B-4bhdA:
undetectable
3ko0C-4bhdA:
undetectable
3ko0D-4bhdA:
undetectable		 3ko0A-4bhdA:
12.38
3ko0B-4bhdA:
12.38
3ko0C-4bhdA:
12.38
3ko0D-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 351
LEU A 332
PHE A 327
ILE A 325
ASP A 318
 None
 1.25A 3ko0A-4bhdA:
undetectable
3ko0B-4bhdA:
undetectable
3ko0C-4bhdA:
undetectable
3ko0D-4bhdA:
undetectable		 3ko0A-4bhdA:
12.38
3ko0B-4bhdA:
12.38
3ko0C-4bhdA:
12.38
3ko0D-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 318
LEU A 332
PHE A 327
ILE A 325
ASP A 351
 None
 1.23A 3ko0C-4bhdA:
undetectable
3ko0D-4bhdA:
undetectable
3ko0E-4bhdA:
undetectable
3ko0F-4bhdA:
undetectable		 3ko0C-4bhdA:
12.38
3ko0D-4bhdA:
12.38
3ko0E-4bhdA:
12.38
3ko0F-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 351
LEU A 332
PHE A 327
ILE A 325
ASP A 318
 None
 1.17A 3ko0C-4bhdA:
undetectable
3ko0D-4bhdA:
undetectable
3ko0E-4bhdA:
undetectable
3ko0F-4bhdA:
undetectable		 3ko0C-4bhdA:
12.38
3ko0D-4bhdA:
12.38
3ko0E-4bhdA:
12.38
3ko0F-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 318
LEU A 332
PHE A 327
ILE A 325
ASP A 351
 None
 1.18A 3ko0E-4bhdA:
undetectable
3ko0F-4bhdA:
undetectable
3ko0G-4bhdA:
undetectable
3ko0H-4bhdA:
undetectable		 3ko0E-4bhdA:
12.38
3ko0F-4bhdA:
12.38
3ko0G-4bhdA:
12.38
3ko0H-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 318
LEU A 332
PHE A 327
ILE A 325
ASP A 351
 None
 1.29A 3ko0G-4bhdA:
undetectable
3ko0H-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0G-4bhdA:
12.38
3ko0H-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 351
LEU A 332
PHE A 327
ILE A 325
ASP A 318
 None
 1.23A 3ko0G-4bhdA:
undetectable
3ko0H-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0G-4bhdA:
12.38
3ko0H-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.14A 3ko0A-4bhdA:
undetectable
3ko0B-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0A-4bhdA:
12.38
3ko0B-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.19A 3ko0K-4bhdA:
undetectable
3ko0L-4bhdA:
undetectable
3ko0S-4bhdA:
undetectable
3ko0T-4bhdA:
undetectable		 3ko0K-4bhdA:
12.38
3ko0L-4bhdA:
12.38
3ko0S-4bhdA:
12.38
3ko0T-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.20A 3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable
3ko0O-4bhdA:
undetectable
3ko0P-4bhdA:
undetectable		 3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
3ko0O-4bhdA:
12.38
3ko0P-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.24A 3ko0K-4bhdA:
undetectable
3ko0L-4bhdA:
undetectable
3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable		 3ko0K-4bhdA:
12.38
3ko0L-4bhdA:
12.38
3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.28A 3ko0O-4bhdA:
undetectable
3ko0P-4bhdA:
undetectable
3ko0Q-4bhdA:
undetectable
3ko0R-4bhdA:
undetectable		 3ko0O-4bhdA:
12.38
3ko0P-4bhdA:
12.38
3ko0Q-4bhdA:
12.38
3ko0R-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.19A 3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable
3ko0O-4bhdA:
undetectable
3ko0P-4bhdA:
undetectable		 3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
3ko0O-4bhdA:
12.38
3ko0P-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.16A 3ko0Q-4bhdA:
undetectable
3ko0R-4bhdA:
undetectable
3ko0S-4bhdA:
undetectable
3ko0T-4bhdA:
undetectable		 3ko0Q-4bhdA:
12.38
3ko0R-4bhdA:
12.38
3ko0S-4bhdA:
12.38
3ko0T-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 196
GLY A 197
ALA A 198
GLY A 233
GLY A 234
 None
 0.79A 3ufnA-4bhdA:
undetectable		 3ufnA-4bhdA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 229
ASN A  32
LEU A  80
PHE A 228
GLY A 202
 None
 1.44A 4pevC-4bhdA:
5.6		 4pevC-4bhdA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 264
ALA A  41
ALA A  37
SER A  35
ALA A 267
 None
 1.25A 4twdA-4bhdA:
undetectable
4twdB-4bhdA:
undetectable
4twdC-4bhdA:
undetectable
4twdD-4bhdA:
undetectable
4twdE-4bhdA:
undetectable		 4twdA-4bhdA:
22.35
4twdB-4bhdA:
22.35
4twdC-4bhdA:
22.35
4twdD-4bhdA:
22.35
4twdE-4bhdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 213
ALA A  86
VAL A 100
ILE A 246
 None
 0.95A 4xe3B-4bhdA:
undetectable		 4xe3B-4bhdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 319
MET A 386
ALA A 390
ILE A 325
 None
 0.81A 4y03A-4bhdA:
undetectable		 4y03A-4bhdA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 179
TYR A 195
ALA A 217
 None
 0.56A 4ybnA-4bhdA:
undetectable		 4ybnA-4bhdA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 132
ASP A 196
ALA A 113
VAL A 137
GLY A 119
 None
 1.03A 5igiA-4bhdA:
0.2		 5igiA-4bhdA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A 226
ASP A 196
GLY A 197
ALA A 205
VAL A 235
 None
 1.38A 5kbwB-4bhdA:
undetectable		 5kbwB-4bhdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 362
ALA A 329
LEU A 332
ILE A 325
 None
 0.86A 5mvmB-4bhdA:
undetectable
5mvmC-4bhdA:
undetectable		 5mvmB-4bhdA:
13.03
5mvmC-4bhdA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 316
MET A 374
ALA A 383
LEU A 291
ALA A 290
 None
 1.26A 5oy02-4bhdA:
undetectable		 5oy02-4bhdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		3 / 3 CYH A 304
MET A 147
ASN A 148
 None
 1.08A 5qh8A-4bhdA:
undetectable		 5qh8A-4bhdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		5 / 10 PRO A 163
MET A 154
ILE A 149
LEU A 165
PHE A 168
 None
 1.24A 5tixB-4bhdA:
undetectable		 5tixB-4bhdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 238
GLU A 104
THR A 105
LEU A 167
 None
 1.18A 5utuH-4bhdA:
undetectable		 5utuH-4bhdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE
(Methanocaldococc
us
jannaschii) 		4 / 6 MET A 374
ALA A 383
LEU A 291
ALA A 290
 None
 1.17A 6fosB-4bhdA:
undetectable		 6fosB-4bhdA:
10.50