SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
 ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
 1.26A 1a4lA-4bhiA:
undetectable		 1a4lA-4bhiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
 ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
 1.25A 1a4lC-4bhiA:
undetectable		 1a4lC-4bhiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 CYH A  38
ARG A  35
CYH A  40
 ZN  A 403 (-2.2A)
ZN  A 403 ( 4.2A)
ZN  A 403 (-2.3A)
 1.45A 1p9gA-4bhiA:
undetectable		 1p9gA-4bhiA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 CYH A  38
ARG A  35
CYH A  43
 ZN  A 403 (-2.2A)
ZN  A 403 ( 4.2A)
ZN  A 403 (-2.3A)
 1.49A 1p9gA-4bhiA:
undetectable		 1p9gA-4bhiA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 7 PHE A 259
SER A 254
PHE A 310
LEU A 346
 None
 1.01A 1qcaA-4bhiA:
undetectable		 1qcaA-4bhiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 278
LEU A 314
PHE A 317
THR A 203
ILE A 289
 None
 1.10A 1re7A-4bhiA:
undetectable		 1re7A-4bhiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 8 ILE A 289
GLY A 234
LEU A 320
PHE A 317
 None
 0.68A 2vctA-4bhiA:
undetectable		 2vctA-4bhiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 8 ILE A 289
GLY A 234
LEU A 320
PHE A 317
 None
 0.64A 2vctB-4bhiA:
undetectable		 2vctB-4bhiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 8 ILE A 289
GLY A 234
LEU A 320
PHE A 317
 None
 0.72A 2vctC-4bhiA:
undetectable		 2vctC-4bhiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 7 ILE A 289
GLY A 234
LEU A 320
PHE A 317
 None
 0.65A 2vctD-4bhiA:
undetectable		 2vctD-4bhiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 277
PHE A 259
MET A 321
PHE A 317
VAL A 286
 None
 0.97A 2ygoA-4bhiA:
undetectable		 2ygoA-4bhiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 LEU A 165
MET A 373
ILE A 231
ASP A 204
 None
None
None
ZN  A 402 (-2.6A)
 1.46A 3hecA-4bhiA:
undetectable		 3hecA-4bhiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 PHE A 330
LYS A 331
ILE A 231
THR A 124
 None
 1.35A 3ia4B-4bhiA:
undetectable		 3ia4B-4bhiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A 217
ASP A 204
PRO A 206
GLY A 234
GLY A 348
 None
ZN  A 402 (-2.6A)
None
None
None
 1.12A 3ku1G-4bhiA:
undetectable		 3ku1G-4bhiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 10 LEU A 125
VAL A 337
GLY A 166
VAL A 150
LEU A 152
 None
 0.79A 3ogpB-4bhiA:
undetectable		 3ogpB-4bhiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 11 SER A 326
GLN A 215
PHE A 340
ILE A 231
HIS A 202
 None
ZN  A 402 ( 4.2A)
None
None
ZN  A 402 ( 3.3A)
 1.46A 4bb2A-4bhiA:
undetectable
4bb2B-4bhiA:
undetectable		 4bb2A-4bhiA:
23.08
4bb2B-4bhiA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 278
LEU A 314
PHE A 317
THR A 203
ILE A 289
 None
 1.01A 4ej1A-4bhiA:
undetectable		 4ej1A-4bhiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 VAL A 237
ALA A 313
GLU A 316
PHE A 317
LEU A 320
 None
 0.98A 4i1rA-4bhiA:
undetectable		 4i1rA-4bhiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 ASN A 190
ASP A 261
ASP A 204
 None
RUJ  A 401 ( 4.7A)
ZN  A 402 (-2.6A)
 0.75A 4obwD-4bhiA:
undetectable		 4obwD-4bhiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 278
LEU A 314
PHE A 317
THR A 203
ILE A 289
 None
 1.06A 4ptjA-4bhiA:
undetectable		 4ptjA-4bhiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 358
TYR A 194
GLN A 215
LEU A 217
LEU A 362
 None
RUJ  A 401 (-4.3A)
ZN  A 402 ( 4.2A)
None
OGA  A 400 (-4.9A)
 1.43A 4qztA-4bhiA:
undetectable		 4qztA-4bhiA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		4 / 5 GLY A 263
TYR A 205
TYR A 177
GLY A 178
 None
RUJ  A 401 (-4.1A)
RUJ  A 401 (-3.8A)
None
 0.94A 5ayfA-4bhiA:
undetectable		 5ayfA-4bhiA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 ILE A 278
LEU A 314
PHE A 317
THR A 203
ILE A 289
 None
 1.06A 5e8qA-4bhiA:
undetectable		 5e8qA-4bhiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 ASN A 333
ASP A 228
GLY A 227
 None
 0.57A 5fctB-4bhiA:
undetectable		 5fctB-4bhiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 GLU A 230
LEU A 199
ALA A 294
ASN A 292
PHE A 291
 None
OGA  A 400 (-4.8A)
None
RUJ  A 401 (-4.1A)
None
 1.43A 5kc0A-4bhiA:
undetectable		 5kc0A-4bhiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 CYH A 219
MET A 332
ASN A 333
 None
 1.30A 5qh8A-4bhiA:
undetectable		 5qh8A-4bhiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A 317
LEU A 346
THR A 203
ASN A 290
GLU A 279
 None
 1.36A 5v1tA-4bhiA:
undetectable		 5v1tA-4bhiA:
22.90