SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 358
PHE A 218
ALA A 372
ALA A 344
LEU A 327
 None
 1.07A 1kt5A-4bhtA:
undetectable		 1kt5A-4bhtA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 239
ALA A 261
SER A 236
ASP A 263
GLN A 309
 None
 1.11A 1nt2A-4bhtA:
undetectable		 1nt2A-4bhtA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ALA A 342
ALA A 372
ALA A 371
VAL A 426
 None
 0.90A 2nyrB-4bhtA:
undetectable		 2nyrB-4bhtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 LEU A 106
LEU A 150
VAL A 171
GLY A 167
 None
 0.94A 2po5A-4bhtA:
2.8		 2po5A-4bhtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 LEU A 103
VAL A  82
GLY A 110
ARG A  96
 None
 0.80A 2wd9A-4bhtA:
2.5		 2wd9A-4bhtA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ARG A 156
MET A 151
THR A 152
LEU A 150
 GOL  A1450 (-3.6A)
None
None
None
 1.41A 3ag2J-4bhtA:
undetectable		 3ag2J-4bhtA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ARG A 156
MET A 151
THR A 152
LEU A 150
 GOL  A1450 (-3.6A)
None
None
None
 1.45A 3ag4J-4bhtA:
undetectable		 3ag4J-4bhtA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 PHE A 366
VAL A 426
ALA A 429
ALA A 344
THR A  34
 None
 1.19A 3dl9B-4bhtA:
undetectable		 3dl9B-4bhtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PHE A 434
GLY A 433
PHE A 115
PHE A 111
 None
 0.97A 3ko0D-4bhtA:
0.2
3ko0E-4bhtA:
undetectable		 3ko0D-4bhtA:
15.11
3ko0E-4bhtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 239
ALA A 261
SER A 236
ASP A 263
GLN A 309
 None
 1.34A 3nmuA-4bhtA:
0.5
3nmuF-4bhtA:
undetectable		 3nmuA-4bhtA:
22.06
3nmuF-4bhtA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 126
GLY A 110
LEU A  51
VAL A 437
ALA A 438
 None
 1.08A 3t7vA-4bhtA:
undetectable		 3t7vA-4bhtA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 221
LEU A 223
ALA A 342
ALA A 367
ILE A 317
 None
 0.94A 3ut5D-4bhtA:
undetectable		 3ut5D-4bhtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 GLY A 126
ALA A  87
SER A  85
TYR A  91
 None
 0.85A 4hyfA-4bhtA:
undetectable		 4hyfA-4bhtA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLY A 126
ALA A  87
SER A  85
TYR A  91
 None
 0.85A 4hyfB-4bhtA:
undetectable		 4hyfB-4bhtA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLY A 126
ALA A  87
SER A  85
TYR A  91
 None
 0.89A 4hyfC-4bhtA:
undetectable		 4hyfC-4bhtA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 ALA A 367
HIS A 410
PHE A 218
LEU A 223
 None
 1.27A 4lufA-4bhtA:
0.0		 4lufA-4bhtA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 ALA A 367
HIS A 410
PHE A 218
LEU A 223
 None
 1.30A 4luhA-4bhtA:
0.6		 4luhA-4bhtA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ASP A 399
ALA A 247
VAL A 216
TYR A 217
GLY A 212
 None
 1.11A 4xp1A-4bhtA:
undetectable		 4xp1A-4bhtA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 PHE A 115
PHE A  24
GLU A  52
VAL A  14
 None
 1.42A 5h4dA-4bhtA:
3.9		 5h4dA-4bhtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 336
GLY A 339
ASN A 338
HIS A 333
GLU A 354
 None
 1.19A 5igyA-4bhtA:
undetectable		 5igyA-4bhtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ARG A 156
MET A 151
THR A 152
LEU A 150
 GOL  A1450 (-3.6A)
None
None
None
 1.35A 5x1fW-4bhtA:
undetectable		 5x1fW-4bhtA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 VAL A 143
GLY A 129
ASP A 168
GLY A  94
PRO A 165
 None
 1.40A 5zniA-4bhtA:
undetectable		 5zniA-4bhtA:
10.77