SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bi3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bi3 SSP1
(Serratia
marcescens) 		5 / 12 SER A  14
LEU A 136
VAL A 120
ALA A  85
HIS A 133
 None
None
None
None
K  A1167 ( 4.9A)
 1.32A 1q23A-4bi3A:
undetectable
1q23B-4bi3A:
undetectable		 1q23A-4bi3A:
19.14
1q23B-4bi3A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bi3 SSP1
(Serratia
marcescens) 		5 / 12 PHE A 122
ALA A  51
ALA A  89
GLY A 131
GLY A  84
 None
None
None
SO4  A1164 (-3.3A)
None
 1.00A 2igtA-4bi3A:
undetectable		 2igtA-4bi3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bi3 SSP1
(Serratia
marcescens) 		5 / 12 PHE A 122
ALA A  51
ALA A  89
GLY A 131
GLY A  84
 None
None
None
SO4  A1164 (-3.3A)
None
 1.01A 2igtB-4bi3A:
undetectable		 2igtB-4bi3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bi3 SSP1
(Serratia
marcescens) 		5 / 12 PHE A 123
TYR A   5
LEU A 162
LEU A  92
LEU A 144
 None
 1.37A 3adxA-4bi3A:
undetectable		 3adxA-4bi3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4bi3 SSP1
(Serratia
marcescens) 		4 / 7 TYR A   5
LEU A 136
ASP A 135
SER A  14
 None
 1.43A 3lslA-4bi3A:
undetectable
3lslD-4bi3A:
undetectable		 3lslA-4bi3A:
20.23
3lslD-4bi3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4bi3 SSP1
(Serratia
marcescens) 		4 / 5 SER A  15
SER A  14
SER A 148
SER A  18
 K  A1167 ( 3.2A)
None
K  A1167 (-4.3A)
None
 1.19A 5hswA-4bi3A:
undetectable		 5hswA-4bi3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 4bi3 SSP1
(Serratia
marcescens) 		5 / 12 ALA A  57
SER A  55
LEU A  88
TYR A 151
TYR A  46
 None
 1.35A 5vlmH-4bi3A:
undetectable		 5vlmH-4bi3A:
22.17