SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 9 GLY A  16
PHE A  20
ILE A  41
ASN A  11
GLN A  65
 None
 1.43A 2a8tA-4bi5A:
0.0		 2a8tA-4bi5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		3 / 3 TYR A 169
GLU A 130
ASN A 138
 None
 0.85A 2y7hC-4bi5A:
undetectable		 2y7hC-4bi5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		3 / 3 THR A 140
LYS A  13
GLU A 134
 None
 0.90A 3ijdB-4bi5A:
9.6		 3ijdB-4bi5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 9 PHE A 126
VAL A 165
VAL A 128
GLN A 147
VAL A 201
 None
 1.33A 3km6B-4bi5A:
undetectable		 3km6B-4bi5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 12 GLY A 215
ALA A 217
ARG A 135
GLU A 130
LEU A 235
 None
 1.19A 4azsA-4bi5A:
undetectable		 4azsA-4bi5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 12 GLY A 215
ALA A 217
ARG A 135
GLU A 130
LEU A 235
 None
 1.22A 4azwA-4bi5A:
undetectable		 4azwA-4bi5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		4 / 8 GLY A 192
VAL A 189
HIS A 190
ILE A 167
 None
 0.79A 4fglD-4bi5A:
undetectable		 4fglD-4bi5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 9 VAL A  40
VAL A  39
VAL A 166
ILE A 125
ALA A  42
 None
 1.13A 4fwdA-4bi5A:
undetectable		 4fwdA-4bi5A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 11 ILE A 249
ALA A  30
ALA A  27
ILE A  41
VAL A  39
 None
 1.14A 4h1nA-4bi5A:
undetectable		 4h1nA-4bi5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		4 / 4 PHE A 245
HIS A  24
GLY A  10
ILE A  41
 None
 0.88A 4k50E-4bi5A:
0.1		 4k50E-4bi5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		4 / 4 PHE A 245
HIS A  24
GLY A  10
ILE A  41
 None
 0.88A 4k50M-4bi5A:
0.1		 4k50M-4bi5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		5 / 12 GLY A 233
ARG A   4
ILE A   8
LEU A 225
LEU A 252
 None
 1.10A 5bw4A-4bi5A:
undetectable		 5bw4A-4bi5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4bi5 TRIOSEPHOSPHATE
ISOMERASE
(Giardia
intestinalis) 		4 / 8 TYR A 169
THR A 182
CYH A 228
LEU A 225
 None
 1.43A 6cnjD-4bi5A:
undetectable
6cnjE-4bi5A:
undetectable		 6cnjD-4bi5A:
13.39
6cnjE-4bi5A:
14.51