SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bi9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 LYS A  46
LEU A  48
SER A  87
THR A 151
 None
 1.08A 1ictB-4bi9A:
undetectable		 1ictB-4bi9A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 LEU A  82
CYH A 120
GLY A 118
GLU A 148
 None
 1.04A 1jlfA-4bi9A:
undetectable
1jlfB-4bi9A:
undetectable		 1jlfA-4bi9A:
20.37
1jlfB-4bi9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  48
LEU A  51
GLY A 146
SER A  55
ARG A 115
 None
 1.32A 2bm9B-4bi9A:
undetectable		 2bm9B-4bi9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A  58
THR A  63
ALA A  53
ALA A  96
ALA A 264
 None
 1.03A 2gluB-4bi9A:
undetectable		 2gluB-4bi9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 GLY A 391
SER A 122
THR A 390
HIS A 385
PHE A 338
 None
 1.45A 2hmaA-4bi9A:
undetectable		 2hmaA-4bi9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 PHE A  81
GLY A  79
GLY A 388
ALA A 121
LEU A 125
 None
 1.10A 2zulA-4bi9A:
undetectable		 2zulA-4bi9A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  52
LEU A  60
ASN A  57
ALA A  96
GLY A  19
 None
 0.98A 3c6gA-4bi9A:
undetectable		 3c6gA-4bi9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  60
ASN A  57
ALA A  96
VAL A 392
GLY A  19
 None
 0.80A 3c6gB-4bi9A:
undetectable		 3c6gB-4bi9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 PHE A  81
GLY A  79
GLY A 388
ALA A 121
LEU A 125
 None
 1.08A 3dmhA-4bi9A:
undetectable		 3dmhA-4bi9A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A 254
GLU A 342
SER A 234
 None
 0.85A 3p2kA-4bi9A:
undetectable		 3p2kA-4bi9A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLU A 408
GLY A 407
TYR A 409
GLN A 401
 None
 1.35A 3w9tB-4bi9A:
undetectable		 3w9tB-4bi9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 GLY A 391
ALA A 126
GLY A 123
VAL A 395
VAL A 431
 None
 1.37A 4c5lC-4bi9A:
undetectable		 4c5lC-4bi9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ALA A 430
ASP A 427
PHE A 338
VAL A 334
THR A 310
 None
 1.50A 4eilB-4bi9A:
undetectable		 4eilB-4bi9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ALA A 430
ASP A 427
PHE A 338
VAL A 334
THR A 310
 None
 1.49A 4eilD-4bi9A:
undetectable		 4eilD-4bi9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 SER A 211
GLY A 378
THR A 366
VAL A 334
 None
 1.12A 4eohA-4bi9A:
undetectable		 4eohA-4bi9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 7 GLY A 146
VAL A 145
PHE A  24
ILE A  21
PHE A 383
 None
 1.16A 4fglC-4bi9A:
undetectable		 4fglC-4bi9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 LYS A  46
LEU A  51
LEU A  48
SER A  87
 None
 1.01A 4ikiB-4bi9A:
undetectable		 4ikiB-4bi9A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ALA A 119
CYH A 120
GLU A 148
HIS A 335
HIS A 385
GLY A 424
 None
 0.78A 4ls7A-4bi9A:
26.8		 4ls7A-4bi9A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ALA A 119
CYH A 120
GLU A 148
HIS A 335
HIS A 385
GLY A 425
 None
 0.99A 4ls7A-4bi9A:
26.8		 4ls7A-4bi9A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 119
CYH A 120
HIS A 335
HIS A 385
GLY A 424
 None
 0.69A 4ls7A-4bi9A:
26.8
4ls7B-4bi9A:
26.8		 4ls7A-4bi9A:
24.95
4ls7B-4bi9A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 119
CYH A 120
HIS A 335
HIS A 385
GLY A 425
 None
 0.87A 4ls7A-4bi9A:
26.8
4ls7B-4bi9A:
26.8		 4ls7A-4bi9A:
24.95
4ls7B-4bi9A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 298
LEU A 344
GLY A 425
ALA A 165
PHE A 179
 None
 1.28A 4retA-4bi9A:
undetectable		 4retA-4bi9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 298
LEU A 344
GLY A 425
ALA A 165
PHE A 179
 None
 1.28A 4retC-4bi9A:
undetectable		 4retC-4bi9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASN A 239
PRO A 248
PHE A 249
PHE A 338
 None
 1.32A 4v32A-4bi9A:
undetectable		 4v32A-4bi9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASN A 239
PRO A 248
PHE A 249
PHE A 338
 None
 1.30A 4v32B-4bi9A:
undetectable		 4v32B-4bi9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASN A 239
PRO A 248
PHE A 249
PHE A 338
 None
 1.41A 4v32C-4bi9A:
undetectable		 4v32C-4bi9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 9 GLN A 128
LEU A 291
ALA A 294
VAL A 313
ALA A 318
 None
 1.48A 5g44A-4bi9A:
undetectable		 5g44A-4bi9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 4 LEU A 319
LEU A 349
GLY A 350
GLU A 327
 None
 1.11A 5hhjA-4bi9A:
undetectable		 5hhjA-4bi9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 GLY A 123
THR A 390
ASN A 422
 None
 0.70A 5odiG-4bi9A:
undetectable		 5odiG-4bi9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 CYH A 337
MET A 423
ASN A 422
 None
 1.28A 5qh8A-4bi9A:
undetectable		 5qh8A-4bi9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		6 / 12 GLY A 388
GLY A 424
GLY A 118
GLY A 123
THR A 429
LYS A 428
 None
 1.46A 5wz2A-4bi9A:
undetectable		 5wz2A-4bi9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ASP A 336
GLN A 394
GLU A 342
ALA A 367
 None
 1.22A 6djzB-4bi9A:
undetectable		 6djzB-4bi9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 THR A 390
GLU A 333
ALA A 341
THR A 310
ALA A 294
 None
 1.45A 6efnA-4bi9A:
undetectable		 6efnA-4bi9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 LEU A 267
ALA A 144
LEU A 435
THR A 420
 None
 0.93A 6f88B-4bi9A:
undetectable		 6f88B-4bi9A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 ASN A 281
PRO A 280
ILE A 438
GLU A 287
 None
 1.21A 6h7uA-4bi9A:
undetectable		 6h7uA-4bi9A:
23.00