SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 12 HIS A  55
HIS A  96
PHE A  19
PHE A  44
ALA A 108
 MN  A1132 (-3.4A)
MN  A1132 (-3.4A)
None
None
None
 1.21A 1a4lA-4bifA:
undetectable		 1a4lA-4bifA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 12 HIS A  55
HIS A  96
PHE A  19
PHE A  44
ALA A 108
 MN  A1132 (-3.4A)
MN  A1132 (-3.4A)
None
None
None
 1.21A 1a4lC-4bifA:
undetectable		 1a4lC-4bifA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 11 ALA A  40
ALA A 108
HIS A  55
ILE A  25
TRP A 120
 None
None
MN  A1132 (-3.4A)
None
None
 1.17A 2x1lA-4bifA:
undetectable		 2x1lA-4bifA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  96
HIS A  53
HIS A  94
 MN  A1132 (-3.4A)
MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
 0.73A 3ag4A-4bifA:
undetectable		 3ag4A-4bifA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  96
HIS A  53
HIS A  94
 MN  A1132 (-3.4A)
MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
 0.76A 3ag4N-4bifA:
undetectable		 3ag4N-4bifA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 12 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
 None
None
None
None
MN  A1132 (-3.6A)
 1.24A 3b0wA-4bifA:
undetectable		 3b0wA-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 12 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
 None
None
None
None
MN  A1132 (-3.6A)
 1.24A 3b0wB-4bifA:
undetectable		 3b0wB-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 9 HIS A  94
HIS A  96
HIS A  53
VAL A 118
ALA A 108
 MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
MN  A1132 (-3.3A)
None
None
 1.49A 5tt3G-4bifA:
undetectable		 5tt3G-4bifA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  53
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 0.46A 5zrdA-4bifA:
undetectable		 5zrdA-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 5 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.4A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 1.07A 5zrdB-4bifA:
undetectable		 5zrdB-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.4A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 1.05A 5zrdC-4bifA:
undetectable		 5zrdC-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		4 / 4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.4A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 1.05A 5zrdD-4bifA:
undetectable		 5zrdD-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		3 / 3 HIS A  96
HIS A  53
HIS A  94
 MN  A1132 (-3.4A)
MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
 0.76A 6giqa-4bifA:
undetectable		 6giqa-4bifA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 10 GLY A  97
LEU A  61
ALA A 108
PHE A  44
HIS A  53
 None
None
None
None
MN  A1132 (-3.3A)
 1.01A 6qgbB-4bifA:
undetectable		 6qgbB-4bifA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 10 GLY A  97
LEU A  61
ALA A 108
PHE A  44
HIS A  53
 None
None
None
None
MN  A1132 (-3.3A)
 0.99A 6qgbD-4bifA:
undetectable		 6qgbD-4bifA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Granulicella
tundricola) 		5 / 10 GLY A  97
LEU A  61
ALA A 108
PHE A  44
HIS A  53
 None
None
None
None
MN  A1132 (-3.3A)
 1.02A 6qgbF-4bifA:
undetectable		 6qgbF-4bifA:
15.08