SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4biz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 9 GLU A 408
LEU A 445
ALA A 437
LEU A 447
LEU A 421
 None
ADP  A 501 (-3.9A)
None
None
ADP  A 501 (-3.8A)
 1.44A 1hwiA-4bizA:
undetectable		 1hwiA-4bizA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 9 LEU A 447
VAL A 391
TYR A 364
GLY A 390
LEU A 421
 None
ADP  A 501 (-4.8A)
ADP  A 501 (-3.8A)
ADP  A 501 ( 4.6A)
ADP  A 501 (-3.8A)
 1.34A 1lwfA-4bizA:
undetectable		 1lwfA-4bizA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 8 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.88A 2eikN-4bizA:
2.3
2eikW-4bizA:
undetectable		 2eikN-4bizA:
17.40
2eikW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 8 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.84A 2eilN-4bizA:
undetectable
2eilW-4bizA:
undetectable		 2eilN-4bizA:
17.40
2eilW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 7 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.86A 2zxwN-4bizA:
3.1
2zxwW-4bizA:
undetectable		 2zxwN-4bizA:
17.40
2zxwW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 12 PHE A 400
LEU A 291
GLY A 418
ILE A 399
ASP A 395
 None
None
ADP  A 501 (-3.3A)
ADP  A 501 (-4.4A)
None
 1.35A 2zznB-4bizA:
undetectable		 2zznB-4bizA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 12 PHE A 400
LEU A 291
GLY A 420
ILE A 399
ASP A 395
 None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-4.4A)
None
 1.43A 2zznB-4bizA:
undetectable		 2zznB-4bizA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 7 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.90A 3ag2N-4bizA:
3.0
3ag2W-4bizA:
undetectable		 3ag2N-4bizA:
17.40
3ag2W-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 8 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.83A 3ag3N-4bizA:
2.4
3ag3W-4bizA:
undetectable		 3ag3N-4bizA:
17.40
3ag3W-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 7 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.95A 3ag4N-4bizA:
2.6
3ag4W-4bizA:
undetectable		 3ag4N-4bizA:
17.40
3ag4W-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 9 ILE A 357
GLY A 420
ALA A 422
THR A 426
VAL A 435
 None
ADP  A 501 (-3.6A)
None
None
None
 1.18A 4r1zA-4bizA:
undetectable		 4r1zA-4bizA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 6 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.88A 5b1aN-4bizA:
3.5
5b1aW-4bizA:
undetectable		 5b1aN-4bizA:
17.40
5b1aW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		4 / 5 GLU A 351
GLU A 316
ASN A 320
GLU A 355
 None
 1.36A 5dwkC-4bizA:
5.5		 5dwkC-4bizA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 12 GLY A 339
VAL A 358
LEU A 332
VAL A 384
GLY A 372
 None
 0.86A 5vopA-4bizA:
undetectable		 5vopA-4bizA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4biz SENSOR PROTEIN CPXA
(Escherichia
coli) 		5 / 12 GLY A 339
VAL A 358
LEU A 332
VAL A 384
ILE A 382
 None
 1.02A 5vopA-4bizA:
undetectable		 5vopA-4bizA:
25.81