SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 353
SER A 308
TYR A 309
 None
 0.59A 1x70A-4bj1A:
undetectable		 1x70A-4bj1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 345
LEU A 317
ASN A 318
TYR A 309
 None
 1.12A 2w98A-4bj1A:
undetectable
2w98B-4bj1A:
undetectable		 2w98A-4bj1A:
20.82
2w98B-4bj1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 305
SER A 308
TYR A 309
LEU A 312
 None
 0.90A 3f33A-4bj1A:
undetectable		 3f33A-4bj1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.38A 3o94A-4bj1A:
undetectable		 3o94A-4bj1A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.42A 3o94B-4bj1A:
undetectable		 3o94B-4bj1A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.40A 3o94C-4bj1A:
undetectable		 3o94C-4bj1A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.39A 3o94D-4bj1A:
undetectable		 3o94D-4bj1A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		4 / 5 THR A 298
PHE A  74
ASN A 310
TYR A 309
 None
 1.32A 4mf6A-4bj1A:
undetectable		 4mf6A-4bj1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 266
LEU A 229
ILE A 224
LEU A 149
PHE A 212
 None
 0.97A 4odrA-4bj1A:
undetectable
4odrB-4bj1A:
undetectable		 4odrA-4bj1A:
14.55
4odrB-4bj1A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 368
LEU A 324
ALA A 325
PHE A 327
LEU A 341
 None
 1.03A 4psyA-4bj1A:
undetectable		 4psyA-4bj1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4bj1 PROTEIN RIF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 236
LEU A 239
GLU A 240
ASN A 108
 None
 0.94A 4ww7A-4bj1A:
undetectable		 4ww7A-4bj1A:
19.23