SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 380
ASP A 114
ASN A 254
 None
 1.10A 2bm9A-4bj6A:
2.8		 2bm9A-4bj6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 345
LEU A 317
ASN A 318
TYR A 309
 None
 1.17A 2w98A-4bj6A:
undetectable
2w98B-4bj6A:
undetectable		 2w98A-4bj6A:
21.75
2w98B-4bj6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  92
SER A 130
TYR A  91
TYR A 252
 None
 1.14A 2y05A-4bj6A:
undetectable
2y05B-4bj6A:
undetectable		 2y05A-4bj6A:
20.81
2y05B-4bj6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 305
SER A 308
TYR A 309
LEU A 312
 None
 0.75A 3f33A-4bj6A:
undetectable		 3f33A-4bj6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 235
ILE A 251
VAL A 208
VAL A 194
LEU A 190
 None
 1.07A 3gwxA-4bj6A:
undetectable		 3gwxA-4bj6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 343
THR A 346
GLN A 351
ASN A 377
 None
 1.02A 3kp2A-4bj6A:
undetectable
3kp2B-4bj6A:
undetectable		 3kp2A-4bj6A:
17.83
3kp2B-4bj6A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.38A 3o94A-4bj6A:
2.3		 3o94A-4bj6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.42A 3o94B-4bj6A:
2.2		 3o94B-4bj6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.40A 3o94C-4bj6A:
2.2		 3o94C-4bj6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 232
LEU A 236
PHE A 247
LEU A 266
ILE A 110
 None
 1.39A 3o94D-4bj6A:
2.1		 3o94D-4bj6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 5 THR A 298
PHE A  74
ASN A 310
TYR A 309
 None
 1.20A 4mf6A-4bj6A:
undetectable		 4mf6A-4bj6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 245
ILE A 138
MET A 195
 None
 0.40A 5i9yA-4bj6A:
undetectable		 5i9yA-4bj6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bj6 RAP1-INTERACTING
FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 366
TYR A 309
THR A 314
LEU A 317
 None
None
SO4  A1390 ( 3.5A)
None
 0.91A 6nmpA-4bj6A:
undetectable
6nmpJ-4bj6A:
undetectable		 6nmpA-4bj6A:
19.28
6nmpJ-4bj6A:
8.12