SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 6 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 1.09A 1rs7B-4bj8A:
undetectable		 1rs7B-4bj8A:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		7 / 7 ASN A  14
LEU A  16
SER A  18
TYR A  33
THR A  35
VAL A  37
TRP A  78
 BTN  A1123 (-3.7A)
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.8A)
BTN  A1123 (-4.5A)
BTN  A1123 (-3.8A)
None
BTN  A1123 (-4.9A)
 0.35A 2uz2A-4bj8A:
18.5		 2uz2A-4bj8A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		5 / 12 VAL A  64
PRO A  62
GLY A  10
LEU A  20
ILE A  52
 None
 0.90A 3ku1A-4bj8A:
undetectable		 3ku1A-4bj8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 6 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 0.91A 4d39B-4bj8A:
undetectable		 4d39B-4bj8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 6 GLY A  88
ILE A  84
GLN A  90
SER A   4
 None
 1.01A 4kcnA-4bj8A:
undetectable		 4kcnA-4bj8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		3 / 3 VAL A  11
THR A  19
ARG A  21
 None
 0.75A 5b2sB-4bj8A:
undetectable		 5b2sB-4bj8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		3 / 3 VAL A  11
THR A  19
ARG A  21
 None
 0.78A 5b2tB-4bj8A:
undetectable		 5b2tB-4bj8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 5 ARG A 113
SER A 100
SER A  74
SER A  76
 None
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.5A)
BTN  A1123 (-3.3A)
 1.27A 5hswA-4bj8A:
undetectable		 5hswA-4bj8A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 8 THR A  40
SER A 100
SER A 111
ASP A 103
 None
BTN  A1123 ( 4.8A)
None
None
 1.02A 5l5fY-4bj8A:
undetectable
5l5fZ-4bj8A:
undetectable		 5l5fY-4bj8A:
24.41
5l5fZ-4bj8A:
20.00