SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 SER A 195
VAL A 192
GLY A 191
ASN A 296
VAL A 272
 None
 1.15A 1a27A-4bjpA:
undetectable		 1a27A-4bjpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 236
LEU A 444
THR A 298
ILE A 299
LEU A 393
 None
 1.14A 1ddsA-4bjpA:
undetectable		 1ddsA-4bjpA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 418
ALA A 516
TYR A 432
LEU A 428
TYR A 514
 None
 1.44A 1jglH-4bjpA:
undetectable
1jglL-4bjpA:
undetectable		 1jglH-4bjpA:
18.73
1jglL-4bjpA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 364
SER A 365
LEU A 421
TYR A 380
GLY A 418
 None
 0.96A 1pxxC-4bjpA:
undetectable		 1pxxC-4bjpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 236
LEU A 444
THR A 298
ILE A 299
LEU A 393
 None
 1.18A 1tdrA-4bjpA:
undetectable		 1tdrA-4bjpA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 421
LEU A 385
GLY A 386
GLN A 427
VAL A 302
 None
 1.22A 2q7lA-4bjpA:
undetectable		 2q7lA-4bjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 8 VAL A 529
VAL A 272
THR A 298
VAL A 531
 None
None
None
GOL  A 623 (-4.7A)
 1.14A 3fhxB-4bjpA:
undetectable		 3fhxB-4bjpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 179
GLY A 180
VAL A 192
ILE A 189
ALA A 176
 EDO  A 642 ( 3.7A)
None
None
None
EDO  A 642 (-4.1A)
 1.02A 3fpjA-4bjpA:
undetectable		 3fpjA-4bjpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 4 GLY A 517
VAL A 529
GLY A 496
THR A 497
 None
None
GOL  A 630 (-3.5A)
GOL  A 630 (-4.0A)
 0.87A 3ib2A-4bjpA:
undetectable		 3ib2A-4bjpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		6 / 12 ILE A 532
GLY A 260
ALA A 276
ALA A 253
VAL A 252
ASN A 250
 None
GOL  A 623 (-3.2A)
None
None
None
None
 1.39A 3jb3A-4bjpA:
undetectable		 3jb3A-4bjpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 11 ASP A 343
PHE A 417
LEU A 369
SER A 365
ILE A 336
 None
 1.33A 3ko0Q-4bjpA:
undetectable
3ko0R-4bjpA:
undetectable
3ko0S-4bjpA:
undetectable
3ko0T-4bjpA:
undetectable		 3ko0Q-4bjpA:
12.57
3ko0R-4bjpA:
12.57
3ko0S-4bjpA:
12.57
3ko0T-4bjpA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 191
PHE A 196
GLU A 193
LEU A 178
ILE A 446
 None
 1.27A 3kvrA-4bjpA:
undetectable		 3kvrA-4bjpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 191
PHE A 196
GLU A 193
LEU A 178
ILE A 446
 None
 1.35A 3kvrB-4bjpA:
undetectable		 3kvrB-4bjpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 11 ILE A 532
SER A 546
ALA A 276
ILE A 553
VAL A 549
 None
None
None
None
GOL  A 625 ( 4.8A)
 0.84A 3kw4A-4bjpA:
undetectable		 3kw4A-4bjpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  82
ALA A  83
LEU A 178
LEU A 393
LEU A 200
 EDO  A 642 (-4.2A)
None
None
None
None
 1.14A 4j24D-4bjpA:
undetectable		 4j24D-4bjpA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 430
ILE A 446
LEU A 393
THR A 424
 None
 1.06A 4mmcA-4bjpA:
undetectable		 4mmcA-4bjpA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 421
LEU A 385
GLY A 386
GLN A 427
VAL A 302
 None
 1.20A 4olmA-4bjpA:
undetectable		 4olmA-4bjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 299
THR A 424
ALA A 429
LEU A 391
LEU A 444
 None
 1.46A 4pbhA-4bjpA:
undetectable		 4pbhA-4bjpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 164
GLN A 142
THR A 201
ASN A 183
 None
 1.36A 4pfjB-4bjpA:
undetectable		 4pfjB-4bjpA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 260
LEU A 178
PHE A 196
GLY A 392
LEU A 426
 GOL  A 623 (-3.2A)
None
None
None
None
 1.28A 4ze1A-4bjpA:
undetectable		 4ze1A-4bjpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 428
ALA A 544
GLY A 496
SER A 307
PRO A 305
 None
None
GOL  A 630 (-3.5A)
GOL  A 630 (-2.9A)
None
 1.34A 5jglA-4bjpA:
undetectable		 5jglA-4bjpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 428
ALA A 544
GLY A 496
SER A 307
PRO A 305
 None
None
GOL  A 630 (-3.5A)
GOL  A 630 (-2.9A)
None
 1.37A 5jglB-4bjpA:
undetectable		 5jglB-4bjpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 393
PHE A 196
LEU A 234
ILE A  74
 None
 0.87A 5mzjA-4bjpA:
undetectable		 5mzjA-4bjpA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN
(Escherichia
coli) 		4 / 7 THR A 560
ARG A 239
ASP A 237
LEU A 273
 None
 0.84A 5uxcA-4bjpA:
undetectable		 5uxcA-4bjpA:
21.68