SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 9 GLY A  87
GLY A  48
PHE A  73
GLU A  75
GLY A  54
 None
 1.30A 1l5lA-4bkoA:
2.0		 1l5lA-4bkoA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 9 GLY A  87
GLY A  48
PHE A  73
GLU A  75
GLY A  54
 None
 1.30A 1l5mA-4bkoA:
1.6		 1l5mA-4bkoA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		3 / 3 GLU A 397
ASN A 109
TRP A  88
 None
 1.18A 1r15C-4bkoA:
undetectable		 1r15C-4bkoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		3 / 3 GLU A 397
ASN A 109
TRP A  88
 None
 1.24A 1r15D-4bkoA:
undetectable		 1r15D-4bkoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		3 / 3 GLU A 397
ASN A 109
TRP A  88
 None
 1.18A 1r15E-4bkoA:
2.6		 1r15E-4bkoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		3 / 3 GLU A 397
ASN A 109
TRP A  88
 None
 1.19A 1r15F-4bkoA:
2.5		 1r15F-4bkoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 9 GLY A  71
SER A 107
LEU A  70
LEU A 129
HIS A  95
 None
 1.13A 1y7iA-4bkoA:
3.4		 1y7iA-4bkoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 ALA A  57
ASP A 133
VAL A 132
VAL A  72
GLY A  71
 None
 1.02A 2qe6B-4bkoA:
undetectable		 2qe6B-4bkoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 10 TYR A 235
ILE A 281
LEU A 181
VAL A 164
LEU A 166
 MES  A1399 (-4.8A)
None
None
None
None
 1.42A 2w98A-4bkoA:
7.0		 2w98A-4bkoA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 ASP A 332
LEU A 270
GLN A 307
ASP A 248
ASP A 324
 None
 1.48A 2x2iB-4bkoA:
undetectable		 2x2iB-4bkoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		4 / 8 GLY A  87
ILE A 305
VAL A 273
SER A  91
 None
None
MES  A1399 (-4.1A)
None
 0.89A 2yoeB-4bkoA:
undetectable
2yoeC-4bkoA:
undetectable		 2yoeB-4bkoA:
21.75
2yoeC-4bkoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 THR A 250
ILE A 205
GLY A 198
ALA A 194
VAL A 193
 None
 1.09A 2yvlA-4bkoA:
5.7		 2yvlA-4bkoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 THR A 250
ILE A 205
GLY A 198
ALA A 194
VAL A 193
 None
 1.09A 2yvlB-4bkoA:
5.6		 2yvlB-4bkoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 GLY A 263
GLY A 262
VAL A 136
PRO A  41
LEU A 312
 None
 1.00A 3m6vA-4bkoA:
6.4		 3m6vA-4bkoA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 GLY A 263
GLY A 262
VAL A 136
PRO A  41
LEU A 312
 None
 0.98A 3m6vB-4bkoA:
6.4		 3m6vB-4bkoA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 GLY A 263
GLY A 262
VAL A 136
PRO A  41
LEU A 312
 None
 1.01A 3m6wA-4bkoA:
5.8		 3m6wA-4bkoA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 GLY A  48
PHE A  74
ASP A 111
ALA A 112
VAL A 139
 None
GOL  A1400 (-4.5A)
GOL  A1400 (-3.6A)
GOL  A1400 (-3.4A)
GOL  A1400 ( 4.7A)
 0.85A 3nvkI-4bkoA:
6.5		 3nvkI-4bkoA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 GLY A  48
PHE A  74
ASP A 111
ALA A 112
VAL A 139
 None
GOL  A1400 (-4.5A)
GOL  A1400 (-3.6A)
GOL  A1400 (-3.4A)
GOL  A1400 ( 4.7A)
 0.92A 3nvkF-4bkoA:
undetectable
3nvkJ-4bkoA:
7.4		 3nvkF-4bkoA:
24.89
3nvkJ-4bkoA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		4 / 6 PRO A   5
VAL A 380
THR A  15
THR A  14
 None
 1.11A 3tneA-4bkoA:
undetectable		 3tneA-4bkoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 PRO A  41
GLY A  64
ASP A 309
VAL A  24
LEU A  55
 None
 1.16A 3v8vA-4bkoA:
6.7		 3v8vA-4bkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 VAL A 139
GLY A  48
VAL A  72
PHE A  74
SER A 114
 GOL  A1400 ( 4.7A)
None
None
GOL  A1400 (-4.5A)
None
 1.22A 4bvaA-4bkoA:
4.2		 4bvaA-4bkoA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 12 VAL A 139
GLY A  48
VAL A  72
PHE A  74
SER A 114
 GOL  A1400 ( 4.7A)
None
None
GOL  A1400 (-4.5A)
None
 1.33A 4bvaB-4bkoA:
4.3		 4bvaB-4bkoA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		5 / 11 ILE A  37
LEU A 134
ALA A  57
ALA A  56
VAL A  31
 None
 1.11A 4h1nA-4bkoA:
undetectable		 4h1nA-4bkoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		3 / 3 VAL A 308
TYR A  53
ALA A  56
 None
 0.56A 4ybnA-4bkoA:
undetectable		 4ybnA-4bkoA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		4 / 6 GLU A 199
GLY A 198
GLY A 197
ASP A 246
 None
 0.82A 5a06D-4bkoA:
5.4		 5a06D-4bkoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4bko PUTATIVE REDUCTASE
BURPS305_1051
(Burkholderia
pseudomallei) 		4 / 6 ARG A 255
ALA A 265
LEU A 254
ALA A 253
 GOL  A1398 (-3.8A)
None
None
None
 1.23A 6fosB-4bkoA:
undetectable		 6fosB-4bkoA:
11.57