SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 10 ALA A1067
GLY A1016
ARG A1095
GLU A1063
LEU A1074
 None
 1.28A 1cmcA-4bkwA:
undetectable
1cmcB-4bkwA:
undetectable		 1cmcA-4bkwA:
12.99
1cmcB-4bkwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 6 PHE A1343
ILE A1400
ALA A1377
MET A1389
 None
 1.12A 1hk2A-4bkwA:
undetectable		 1hk2A-4bkwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 9 ASP A1284
GLY A1285
ILE A1417
ILE A1291
ILE A1283
 None
 0.97A 1hpvA-4bkwA:
undetectable		 1hpvA-4bkwA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 8 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.78A 1hwiB-4bkwA:
undetectable		 1hwiB-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 8 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.76A 1hwiD-4bkwA:
undetectable		 1hwiD-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 8 CYH A1348
LEU A1392
ALA A1395
LEU A1396
 None
 0.77A 1hwiC-4bkwA:
undetectable		 1hwiC-4bkwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 PHE A 996
ILE A 907
VAL A 928
ARG A1093
LEU A1025
 None
 0.94A 2g78A-4bkwA:
undetectable		 2g78A-4bkwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 5 LEU A1120
ILE A1072
SER A1201
GLY A1225
 None
 0.99A 2otfA-4bkwA:
undetectable		 2otfA-4bkwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 GLY A1363
GLY A1285
GLY A1381
GLY A1378
VAL A1280
 None
 0.97A 2oxtA-4bkwA:
undetectable		 2oxtA-4bkwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 7 ILE A1137
PHE A1203
ARG A1143
MET A1147
 None
 1.14A 2zxwN-4bkwA:
undetectable
2zxwW-4bkwA:
undetectable		 2zxwN-4bkwA:
23.28
2zxwW-4bkwA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 8 THR A1050
GLY A 969
ALA A 972
ILE A1417
 None
 0.82A 3jusA-4bkwA:
undetectable		 3jusA-4bkwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 8 THR A1050
GLY A 969
ALA A 972
ILE A1417
 None
 0.82A 3jusA-4bkwA:
undetectable		 3jusA-4bkwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.94A 3kkzA-4bkwA:
undetectable		 3kkzA-4bkwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.93A 3kkzB-4bkwA:
undetectable		 3kkzB-4bkwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 7 LEU A1002
ASP A1005
ALA A1006
TYR A1035
 None
 0.87A 3rodD-4bkwA:
undetectable		 3rodD-4bkwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ASN A1014
VAL A1012
ILE A 978
GLY A1056
ILE A1057
 None
 1.05A 3spkB-4bkwA:
undetectable		 3spkB-4bkwA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 1.00A 3sxjA-4bkwA:
undetectable		 3sxjA-4bkwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 1.00A 3sxjB-4bkwA:
undetectable		 3sxjB-4bkwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.87A 3t7sA-4bkwA:
undetectable		 3t7sA-4bkwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.97A 3t7sB-4bkwA:
undetectable		 3t7sB-4bkwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.86A 3t7sC-4bkwA:
undetectable		 3t7sC-4bkwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 ARG A1095
GLY A1031
GLN A1060
SER A1021
GLU A1063
 None
 0.96A 3t7sD-4bkwA:
undetectable		 3t7sD-4bkwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 7 ILE A1417
ILE A1283
THR A1367
LEU A1317
 None
 0.86A 3ua5B-4bkwA:
undetectable		 3ua5B-4bkwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 THR A1312
ARG A1310
GLY A 969
ALA A1008
GLY A1009
 None
 1.24A 3v3oA-4bkwA:
undetectable		 3v3oA-4bkwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 7 LEU A1089
TYR A1053
LEU A1043
TYR A 957
 None
 1.11A 4b3qA-4bkwA:
undetectable		 4b3qA-4bkwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 4 PRO A1071
LEU A1034
ILE A1059
ARG A1095
 None
 1.44A 4f4dA-4bkwA:
undetectable		 4f4dA-4bkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 5 TYR A1085
THR A1039
PRO A1086
VAL A1036
 None
 1.31A 4mjqA-4bkwA:
undetectable		 4mjqA-4bkwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 7 ILE A1137
PHE A1203
ARG A1143
MET A1147
LEU A1242
 None
 1.37A 5b3sN-4bkwA:
undetectable
5b3sW-4bkwA:
undetectable		 5b3sN-4bkwA:
23.28
5b3sW-4bkwA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 5 THR A1198
HIS A1172
ALA A1169
ASP A1170
 EDO  A2370 (-4.2A)
None
None
None
 1.26A 5mfxA-4bkwA:
undetectable		 5mfxA-4bkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		4 / 6 PRO A1282
VAL A1279
VAL A1275
ILE A1417
 None
 0.65A 5pbeA-4bkwA:
undetectable		 5pbeA-4bkwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens) 		5 / 12 LEU A1046
LEU A1043
GLY A1056
TYR A1053
PRO A1049
 None
 1.09A 6ce2B-4bkwA:
undetectable		 6ce2B-4bkwA:
10.55