SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER A 312
GLU B 337
ASP A 198
 None
None
MG  A1341 (-2.9A)
 0.74A 2avdB-4bl0A:
undetectable		 2avdB-4bl0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		3 / 3 SER A 212
ASP A 157
CYH A 108
 None
 0.90A 2br4E-4bl0A:
undetectable		 2br4E-4bl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		5 / 12 SER A  34
THR A  36
VAL A  37
LEU A  70
ILE A  72
 None
 1.31A 2fj1A-4bl0A:
undetectable		 2fj1A-4bl0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 PRO B 316
ASN A 249
ARG A 242
 None
 1.09A 2qeuB-4bl0B:
undetectable		 2qeuB-4bl0B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  13
SER A  30
ILE A  17
SER A 331
 None
 1.14A 2xz5B-4bl0A:
undetectable
2xz5E-4bl0A:
undetectable		 2xz5B-4bl0A:
22.22
2xz5E-4bl0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 334
ALA A 269
ALA A 290
MET A   1
 None
 1.30A 3d91A-4bl0A:
undetectable		 3d91A-4bl0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  92
PRO A  10
SER A  52
VAL A  84
ILE A  72
 None
 1.25A 3rfaA-4bl0A:
undetectable		 3rfaA-4bl0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 110
LEU A  82
LYS A  83
 None
 0.70A 3sueD-4bl0A:
undetectable		 3sueD-4bl0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 340
ALA B 341
ILE A 104
GLY A  79
LEU A 102
 None
 1.01A 5gtrA-4bl0B:
undetectable		 5gtrA-4bl0B:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 124
ILE A 116
ILE A 107
ILE A 104
ILE A  81
 None
 1.08A 5murE-4bl0A:
undetectable		 5murE-4bl0A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ILE B 343
PHE A 316
ASP A  12
SER A 312
 None
 1.37A 5nr3A-4bl0B:
undetectable		 5nr3A-4bl0B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ILE B 343
PHE A 316
ASP A  12
SER A 331
 None
 1.22A 5nr3A-4bl0B:
undetectable		 5nr3A-4bl0B:
19.33