SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 11 VAL A 131
ILE A  34
ILE A  80
VAL A  95
PHE A 116
 None
 1.07A 1gx9A-4bl3A:
undetectable		 1gx9A-4bl3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 ASP A 586
PHE A 617
VAL A 579
 None
 0.78A 1kijB-4bl3A:
undetectable		 1kijB-4bl3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 6 ASP A  48
ASP A  35
ASN A  31
GLU A 119
 None
 1.33A 1rjdA-4bl3A:
undetectable		 1rjdA-4bl3A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 6 ASP A  48
ASP A  35
ASN A  31
GLU A 119
 None
 1.33A 1rjdB-4bl3A:
undetectable		 1rjdB-4bl3A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 LYS A 280
ASP A 274
ASN A 260
 None
 0.86A 2bm9A-4bl3A:
undetectable		 2bm9A-4bl3A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 6 TYR A 287
TYR A 496
GLN A 333
ILE A 328
 None
 1.46A 2pgzD-4bl3A:
undetectable
2pgzE-4bl3A:
undetectable		 2pgzD-4bl3A:
16.54
2pgzE-4bl3A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 PHE A 467
ILE A 407
GLY A 574
ILE A 595
 None
 0.98A 2qwxA-4bl3A:
undetectable
2qwxB-4bl3A:
undetectable		 2qwxA-4bl3A:
18.21
2qwxB-4bl3A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 SER A 335
ASN A 339
ASP A 654
ARG A 589
 None
 1.09A 2v57A-4bl3A:
undetectable		 2v57A-4bl3A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 SER A 335
ASN A 339
ASP A 654
ARG A 589
 None
 1.09A 2v57C-4bl3A:
undetectable		 2v57C-4bl3A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 5 GLN A 140
ALA A 310
ILE A 301
ARG A 110
 CL  A1011 ( 4.0A)
CL  A1011 ( 4.2A)
None
None
 1.32A 2z0aA-4bl3A:
undetectable		 2z0aA-4bl3A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 SER A 476
GLU A 523
ASP A 509
 None
 0.80A 2zthA-4bl3A:
undetectable		 2zthA-4bl3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 SER A 649
GLY A 345
ILE A 397
THR A 363
PHE A 498
 None
 1.37A 3a25A-4bl3A:
undetectable		 3a25A-4bl3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 SER A 476
GLU A 523
ASP A 509
 None
 0.80A 3bwmA-4bl3A:
undetectable		 3bwmA-4bl3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 SER A 476
GLU A 523
ASP A 509
 None
 0.84A 3bwyA-4bl3A:
undetectable		 3bwyA-4bl3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 10 ILE A 526
ILE A 524
GLY A 518
PHE A 467
LEU A 486
 None
 1.20A 3elzB-4bl3A:
1.2		 3elzB-4bl3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 LEU A 360
ASP A 495
GLY A 355
HIS A 548
PHE A 498
 None
 0.98A 3glqA-4bl3A:
undetectable		 3glqA-4bl3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 LEU A 360
ASP A 495
GLY A 355
HIS A 548
PHE A 498
 None
 0.91A 3n58A-4bl3A:
undetectable		 3n58A-4bl3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 11 LEU A 486
ILE A 544
GLY A 542
ALA A 537
LEU A 538
 None
 1.14A 3n8yA-4bl3A:
undetectable		 3n8yA-4bl3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ILE A 459
LEU A 455
ALA A 410
ILE A 595
LEU A 538
 None
 0.85A 3vrmA-4bl3A:
undetectable		 3vrmA-4bl3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 5 VAL A 529
LEU A 532
SER A 533
MET A 627
 None
 0.98A 4e1gA-4bl3A:
undetectable		 4e1gA-4bl3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 SER A 362
ALA A 630
SER A 346
THR A 348
 None
 0.49A 4iklA-4bl3A:
undetectable
4iklB-4bl3A:
undetectable		 4iklA-4bl3A:
11.25
4iklB-4bl3A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ALA A 458
LEU A 414
GLY A 596
LYS A 597
LEU A 538
 None
 1.23A 4kykA-4bl3A:
undetectable
4kykB-4bl3A:
undetectable		 4kykA-4bl3A:
15.73
4kykB-4bl3A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 LEU A 408
ALA A 458
LYS A 597
LEU A 414
GLY A 542
 None
 1.13A 4l9qB-4bl3A:
undetectable		 4l9qB-4bl3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 PRO A 370
MET A 372
TYR A 369
 None
 0.82A 4qa2B-4bl3A:
undetectable		 4qa2B-4bl3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 ARG A  83
GLN A  81
GLU A  38
 None
 0.86A 4tvtA-4bl3A:
undetectable		 4tvtA-4bl3A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 9 LEU A 408
ILE A 618
MET A 628
SER A 536
LEU A 532
 None
 1.15A 4x3mB-4bl3A:
undetectable		 4x3mB-4bl3A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 SER A 476
GLU A 523
ASP A 509
 None
 0.79A 4xudA-4bl3A:
undetectable		 4xudA-4bl3A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 LEU A 360
VAL A 529
GLY A 402
THR A 348
LEU A 525
 None
 1.07A 5byjA-4bl3A:
undetectable		 5byjA-4bl3A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 6 ILE A 631
ALA A 359
VAL A 361
VAL A 652
 None
 0.90A 5eclD-4bl3A:
undetectable		 5eclD-4bl3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ILE A 192
VAL A 368
GLY A 172
THR A 235
LEU A 224
 None
 1.38A 5esgA-4bl3A:
undetectable		 5esgA-4bl3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ILE A 526
ALA A 630
SER A 346
VAL A 529
ILE A 531
 None
 1.26A 5mlmA-4bl3A:
undetectable		 5mlmA-4bl3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ASN A 464
GLN A 521
SER A 598
GLY A 599
THR A 600
 None
 0.65A 5oj0A-4bl3A:
29.6		 5oj0A-4bl3A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		5 / 12 ASN A 464
THR A 582
SER A 598
GLY A 599
THR A 600
 None
 1.12A 5oj0A-4bl3A:
29.6		 5oj0A-4bl3A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.91A 5sxqA-4bl3A:
undetectable		 5sxqA-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.91A 5sxqB-4bl3A:
undetectable		 5sxqB-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.89A 5sxtA-4bl3A:
undetectable		 5sxtA-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.89A 5sxtB-4bl3A:
undetectable		 5sxtB-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.88A 5syjA-4bl3A:
undetectable		 5syjA-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		4 / 8 GLU A 284
VAL A 277
GLY A 152
GLN A 292
 None
MUR  A1677 (-3.4A)
None
MUR  A1677 ( 4.9A)
 0.92A 5syjB-4bl3A:
undetectable		 5syjB-4bl3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME
(Staphylococcus
aureus) 		3 / 3 LEU A 474
SER A 476
PHE A 479
 None
 0.55A 6fgcA-4bl3A:
undetectable		 6fgcA-4bl3A:
22.29