SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4blf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK2_A_T44A3003_1 (SERUM ALBUMIN)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	4 / 6	ILE A 305 LYS A 296 LYS A 298 ALA A 294	None	1.27A	1hk2A-4blfA: undetectable	1hk2A-4blfA: 18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTX_A_CVIA200_0 (HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	5 / 12	THR A 217 TYR A 250 ILE A 246 ILE A 236 TYR A 235	None	1.12A	1jtxA-4blfA: undetectable	1jtxA-4blfA: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_C_SAMC1003_1 (SAM DEPENDENT METHYLTRANSFERASE)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	4 / 4	ASP A 262 ASP A 126 ASP A 281 GLY A 242	None	1.17A	2igtC-4blfA: undetectable	2igtC-4blfA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXV_D_MTXD2000_2 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	3 / 3	LEU A 264 ARG A 113 ASN A 135	None	0.74A	3qxvD-4blfA: undetectable	3qxvD-4blfA: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_D_SUED1201_2 (NS3 PROTEASE, NS4A PROTEIN)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	3 / 3	TYR A 117 LEU A 307 LYS A 308	None	0.75A	3sueD-4blfA: undetectable	3sueD-4blfA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YO9_B_ACTB401_0 (3C-LIKE PROTEINASE)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	3 / 3	ARG A 244 ASP A 262 TYR A 241	None	0.96A	4yo9B-4blfA: undetectable	4yo9B-4blfA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_B_X2NB590_2 (CYP51 VARIANT1)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	3 / 3	PRO A 161 LEU A 264 SER A 258	None	0.79A	5fsaB-4blfA: undetectable	5fsaB-4blfA: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCG_A_08YA602_1 (CYTOCHROME P450 3A4)	4blf	SINGLE-STRAND DNA-BINDING PROTEIN (Agrobacterium tumefaciens)	5 / 12	ASP A 115 ILE A 263 THR A 132 ALA A 294 GLU A 304	None	1.15A	5vcgA-4blfA: undetectable	5vcgA-4blfA: 17.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HK2_A_T44A3003_1","SERUM ALBUMIN","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",4,"ILE A 305;LYS A 296;LYS A 298;ALA A 294","None","1.27A","1hk2A-4blfA:undetectable","1hk2A-4blfA:18.61"],["1JTX_A_CVIA200_0","HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",5,"THR A 217;TYR A 250;ILE A 246;ILE A 236;TYR A 235","None","1.12A","1jtxA-4blfA:undetectable","1jtxA-4blfA:22.95"],["2IGT_C_SAMC1003_1","SAM DEPENDENT METHYLTRANSFERASE","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",4,"ASP A 262;ASP A 126;ASP A 281;GLY A 242","None","1.17A","2igtC-4blfA:undetectable","2igtC-4blfA:22.29"],["3QXV_D_MTXD2000_2","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",3,"LEU A 264;ARG A 113;ASN A 135","None","0.74A","3qxvD-4blfA:undetectable","3qxvD-4blfA:21.39"],["3SUE_D_SUED1201_2","NS3 PROTEASE, NS4A PROTEIN","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",3,"TYR A 117;LEU A 307;LYS A 308","None","0.75A","3sueD-4blfA:undetectable","3sueD-4blfA:23.08"],["4YO9_B_ACTB401_0","3C-LIKE PROTEINASE","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",3,"ARG A 244;ASP A 262;TYR A 241","None","0.96A","4yo9B-4blfA:undetectable","4yo9B-4blfA:21.83"],["5FSA_B_X2NB590_2","CYP51 VARIANT1","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",3,"PRO A 161;LEU A 264;SER A 258","None","0.79A","5fsaB-4blfA:undetectable","5fsaB-4blfA:18.50"],["5VCG_A_08YA602_1","CYTOCHROME P450 3A4","4blf","SINGLE-STRAND DNA-BINDING PROTEIN","Agrobacterium tumefaciens",5,"ASP A 115;ILE A 263;THR A 132;ALA A 294;GLU A 304","None","1.15A","5vcgA-4blfA:undetectable","5vcgA-4blfA:17.76"]]