SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4blu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 4 SER A 100
LEU A 116
TYR A  38
GLY A  44
 None
None
None
EDO  A1284 ( 4.7A)
 1.49A 1liiA-4bluA:
3.8		 1liiA-4bluA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 GLY A  99
TYR A  38
LEU A 160
ASP A 164
ASP A  15
 EDO  A1283 ( 3.8A)
None
None
TRS  A1281 ( 3.0A)
EDO  A1283 ( 2.8A)
 1.47A 2vqyA-4bluA:
1.1		 2vqyA-4bluA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.70A 2zthA-4bluA:
12.5		 2zthA-4bluA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.79A 3bwmA-4bluA:
11.9		 3bwmA-4bluA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.81A 3bwyA-4bluA:
12.1		 3bwyA-4bluA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 TYR A 192
ILE A 219
ILE A 216
LYS A 185
GLY A 183
 None
 1.05A 3em0B-4bluA:
undetectable		 3em0B-4bluA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 LEU A 220
ILE A 208
GLY A 239
ILE A 241
LEU A 257
 None
 1.05A 3uj6A-4bluA:
10.3		 3uj6A-4bluA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 6 GLY A  44
GLU A 118
ASP A 143
ASP A 164
 EDO  A1284 ( 4.7A)
None
None
TRS  A1281 ( 3.0A)
 1.05A 3vywC-4bluA:
8.1		 3vywC-4bluA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		8 / 12 ASP A  40
HIS A  42
GLY A  44
GLY A  99
LEU A 119
HIS A 120
ASP A 123
PRO A 166
 None
None
EDO  A1284 ( 4.7A)
EDO  A1283 ( 3.8A)
None
None
None
None
 0.69A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		9 / 12 LYS A  18
ASP A  40
HIS A  42
GLY A  44
GLY A  99
LEU A 119
HIS A 120
ASP A 123
GLY A 144
 TRS  A1281 ( 2.8A)
None
None
EDO  A1284 ( 4.7A)
EDO  A1283 ( 3.8A)
None
None
None
None
 0.42A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 6 HIS A  19
SER A 100
GLU A 118
ASP A 143
ASP A 164
 None
None
None
None
TRS  A1281 ( 3.0A)
 0.41A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		11 / 12 LYS A  18
HIS A  19
ASP A  40
HIS A  42
GLY A  44
TYR A  48
GLY A  99
LEU A 119
HIS A 120
GLY A 144
ASP A 164
 TRS  A1281 ( 2.8A)
None
None
None
EDO  A1284 ( 4.7A)
EDO  A1283 (-3.6A)
EDO  A1283 ( 3.8A)
None
None
None
TRS  A1281 ( 3.0A)
 0.45A 4blvB-4bluA:
49.2		 4blvB-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		10 / 12 LYS A  18
HIS A  19
HIS A  42
TYR A  48
GLY A  99
SER A 100
LEU A 119
HIS A 120
GLY A 144
ASP A 164
 TRS  A1281 ( 2.8A)
None
None
EDO  A1283 (-3.6A)
EDO  A1283 ( 3.8A)
None
None
None
None
TRS  A1281 ( 3.0A)
 0.67A 4blvB-4bluA:
49.2		 4blvB-4bluA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 6 ILE A 222
GLY A 239
ILE A 163
LEU A 249
 None
 0.71A 4o8fB-4bluA:
undetectable		 4o8fB-4bluA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.72A 4xudA-4bluA:
11.8		 4xudA-4bluA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 5 ILE A 241
ILE A 222
TYR A 196
GLU A 223
 None
 1.01A 4zzcE-4bluA:
undetectable		 4zzcE-4bluA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 ASP A 143
ASP A 164
PRO A 166
GLY A  44
GLU A 118
 None
TRS  A1281 ( 3.0A)
None
EDO  A1284 ( 4.7A)
None
 1.16A 5hfjF-4bluA:
3.3		 5hfjF-4bluA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 4 ASP A  40
HIS A 120
SER A 122
GLU A 118
 None
 1.38A 5hfjG-4bluA:
2.4		 5hfjG-4bluA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 8 ALA A  80
LEU A  74
ILE A  65
VAL A  16
 None
 0.85A 5nujA-4bluA:
undetectable		 5nujA-4bluA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 5 ASP A 123
GLU A 140
ARG A 128
THR A 117
 None
 1.48A 5uxcA-4bluA:
undetectable		 5uxcA-4bluA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 LEU A 257
ILE A 222
GLY A 239
LEU A 162
LEU A 211
 None
 0.96A 5ycnA-4bluA:
undetectable		 5ycnA-4bluA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 6 SER A 100
GLU A 118
ASP A 143
ASP A 164
 None
None
None
TRS  A1281 ( 3.0A)
 0.90A 5zw4A-4bluA:
10.7		 5zw4A-4bluA:
24.83