SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.70A 1q23H-4bmbA:
undetectable		 1q23H-4bmbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.66A 1q23J-4bmbA:
undetectable		 1q23J-4bmbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 7 CYH A  78
PHE A  46
PHE A  64
LEU A 138
 None
 1.04A 1qcaA-4bmbA:
undetectable		 1qcaA-4bmbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.81A 1sg9B-4bmbA:
undetectable		 1sg9B-4bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A  21
ILE A 146
ILE A  35
GLY A 150
ILE A  11
 None
 0.86A 2b60A-4bmbA:
undetectable		 2b60A-4bmbA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A  21
ILE A 146
ILE A  35
GLY A 150
ILE A  11
 None
 1.01A 2hs1A-4bmbA:
undetectable		 2hs1A-4bmbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 7 GLY A  21
PHE A 151
ILE A  11
PHE A 153
 None
 1.03A 2qmzA-4bmbA:
undetectable
2qmzB-4bmbA:
undetectable		 2qmzA-4bmbA:
18.47
2qmzB-4bmbA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 7 PHE A  19
PHE A 114
ILE A 130
GLY A 139
 None
 1.00A 2v0mC-4bmbA:
undetectable		 2v0mC-4bmbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.07A 3eeyE-4bmbA:
undetectable		 3eeyE-4bmbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.11A 3eeyJ-4bmbA:
undetectable		 3eeyJ-4bmbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 9 GLY A 127
ASP A 112
VAL A 109
GLY A 131
ILE A 130
 None
 0.99A 3ektA-4bmbA:
undetectable		 3ektA-4bmbA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.25A 3galA-4bmbA:
23.3		 3galA-4bmbA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  65
ASN A  67
ARG A  45
TRP A  86
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.9A)
LAT  A1155 (-3.6A)
 1.22A 3galB-4bmbA:
23.0		 3galB-4bmbA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.35A 3galB-4bmbA:
23.0		 3galB-4bmbA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 11 PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
 None
 1.44A 3h6tA-4bmbA:
undetectable
3h6tC-4bmbA:
undetectable		 3h6tA-4bmbA:
20.41
3h6tC-4bmbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 6 PHE A  46
VAL A 116
THR A 123
PHE A  97
 None
 1.36A 3ltwA-4bmbA:
undetectable		 3ltwA-4bmbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.48A 3mbhB-4bmbA:
undetectable		 3mbhB-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.46A 3mbhC-4bmbA:
undetectable		 3mbhC-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.49A 3mbhD-4bmbA:
undetectable		 3mbhD-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.49A 3mbhE-4bmbA:
undetectable		 3mbhE-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 11 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.48A 3mbhF-4bmbA:
undetectable		 3mbhF-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 10 ILE A 107
SER A 148
ILE A  12
ILE A  35
THR A  31
 None
 1.22A 3qgtA-4bmbA:
undetectable		 3qgtA-4bmbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 11 LEU A  27
ALA A  63
ASP A  61
ILE A  23
ILE A 135
 None
 1.11A 3s53B-4bmbA:
undetectable		 3s53B-4bmbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		3 / 3 SER A  54
GLY A  53
GLN A  51
 None
 0.60A 3v4tH-4bmbA:
undetectable		 3v4tH-4bmbA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 8 ILE A  35
ILE A 149
PHE A  19
GLY A  21
 None
 0.79A 4acbC-4bmbA:
undetectable		 4acbC-4bmbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 9 GLY A 127
ASP A 112
VAL A 109
GLY A 131
ILE A 130
 None
 1.04A 4dqcB-4bmbA:
undetectable		 4dqcB-4bmbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 10 GLY A 127
ASP A 112
VAL A 109
GLY A 131
ILE A 130
 None
 0.99A 4njtB-4bmbA:
undetectable		 4njtB-4bmbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 11 GLY A  21
ILE A 146
ILE A  35
GLY A 150
ILE A  11
 None
 0.93A 4q1xA-4bmbA:
undetectable		 4q1xA-4bmbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.07A 5mugA-4bmbA:
undetectable		 5mugA-4bmbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 9 LEU A 138
VAL A  48
ILE A 149
GLY A 150
PHE A  97
 None
 0.96A 5vkqC-4bmbA:
undetectable
5vkqD-4bmbA:
undetectable		 5vkqC-4bmbA:
6.34
5vkqD-4bmbA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 7 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.17A 6b8kA-4bmbA:
23.2		 6b8kA-4bmbA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 8 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.42A 6b94A-4bmbA:
18.9		 6b94A-4bmbA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 10 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.41A 6b94A-4bmbA:
18.9
6b94B-4bmbA:
18.6		 6b94A-4bmbA:
29.57
6b94B-4bmbA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4bmb GALECTIN-8
(Homo
sapiens) 		3 / 3 GLU A 133
ASP A  28
PRO A  29
 None
 0.74A 6berA-4bmbA:
undetectable		 6berA-4bmbA:
10.77