SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN A 440
LEU A 415
ALA A 418
LEU A 419
 None
 0.98A 1hwiB-4bmdA:
undetectable		 1hwiB-4bmdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN A 440
LEU A 415
ALA A 418
LEU A 419
 None
 0.98A 1hwiC-4bmdA:
undetectable		 1hwiC-4bmdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 11 ASN A 363
LEU A 325
PHE A 313
LEU A 321
CYH A 370
 None
 1.41A 1xpqA-4bmdA:
0.0		 1xpqA-4bmdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A 322
GLN A 331
GLY A 330
SER A 326
 None
 0.91A 4fu8A-4bmdA:
undetectable		 4fu8A-4bmdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 443
LEU A 469
LEU A 419
GLY A 409
LEU A 412
 None
 0.91A 6b0cD-4bmdA:
undetectable		 6b0cD-4bmdA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 10 SER A 392
LEU A 469
ASP A 480
ILE A 473
GLY A 476
 None
 1.38A 6dlzA-4bmdA:
undetectable
6dlzD-4bmdA:
2.0		 6dlzA-4bmdA:
14.72
6dlzD-4bmdA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 473
GLY A 476
SER A 392
LEU A 469
ASP A 480
 None
 1.39A 6dlzB-4bmdA:
2.4
6dlzC-4bmdA:
undetectable		 6dlzB-4bmdA:
14.72
6dlzC-4bmdA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 10 SER A 392
LEU A 469
ASP A 480
ILE A 473
GLY A 476
 None
 1.39A 6dm1A-4bmdA:
undetectable
6dm1D-4bmdA:
2.1		 6dm1A-4bmdA:
14.72
6dm1D-4bmdA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 473
GLY A 476
SER A 392
LEU A 469
ASP A 480
 None
 1.39A 6dm1B-4bmdA:
2.7
6dm1C-4bmdA:
undetectable		 6dm1B-4bmdA:
14.72
6dm1C-4bmdA:
14.72