SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4boc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 803
ASP A1128
ASP A1151
TYR A 807
 None
None
C  R   9 ( 2.8A)
None
 1.39A 1cebA-4bocA:
undetectable		 1cebA-4bocA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A1127
HIS A1175
LEU A1219
GLY A 935
PHE A1123
 None
 1.45A 1d4fC-4bocA:
undetectable		 1d4fC-4bocA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A1127
HIS A1175
LEU A1219
GLY A 935
PHE A1123
 None
 1.44A 1d4fD-4bocA:
undetectable		 1d4fD-4bocA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.07A 1dz9A-4bocA:
undetectable		 1dz9A-4bocA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A1040
TYR A 956
GLY A 958
LEU A 928
 None
 0.73A 1jlbA-4bocA:
2.3		 1jlbA-4bocA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A1128
LEU A1127
THR A1047
ILE A1050
LEU A1054
 None
 1.13A 1qzfA-4bocA:
undetectable		 1qzfA-4bocA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A1128
LEU A1127
THR A1047
ILE A1050
LEU A1054
 None
 1.12A 1qzfB-4bocA:
undetectable		 1qzfB-4bocA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A1128
LEU A1127
THR A1047
ILE A1050
LEU A1054
 None
 1.12A 1qzfC-4bocA:
undetectable		 1qzfC-4bocA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A1128
LEU A1127
THR A1047
ILE A1050
LEU A1054
 None
 1.13A 1qzfD-4bocA:
undetectable		 1qzfD-4bocA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A1128
LEU A1127
THR A1047
ILE A1050
LEU A1054
 None
 1.13A 1qzfE-4bocA:
undetectable		 1qzfE-4bocA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 479
LEU A 578
PHE A 229
CYH A 233
GLN A 238
 None
 1.17A 1skxA-4bocA:
undetectable		 1skxA-4bocA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.06A 1t85A-4bocA:
undetectable		 1t85A-4bocA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 851
VAL A 846
THR A 894
ASP A 870
 None
 0.98A 1uyuA-4bocA:
undetectable		 1uyuA-4bocA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.06A 1uyuB-4bocA:
undetectable		 1uyuB-4bocA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 408
LEU A 404
LEU A 526
LEU A 665
ARG A 518
 None
 1.09A 2ceoA-4bocA:
undetectable		 2ceoA-4bocA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 717
VAL A 820
LEU A 720
ASP A 819
 None
 1.01A 2ddwA-4bocA:
undetectable		 2ddwA-4bocA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.05A 2feuA-4bocA:
undetectable		 2feuA-4bocA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 277
THR A 346
VAL A 347
LEU A 320
ILE A 316
 None
 1.39A 2fj1A-4bocA:
2.1		 2fj1A-4bocA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.37A 2vxaA-4bocA:
undetectable
2vxaC-4bocA:
undetectable
2vxaE-4bocA:
undetectable		 2vxaA-4bocA:
4.91
2vxaC-4bocA:
4.91
2vxaE-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.36A 2vxaA-4bocA:
undetectable
2vxaB-4bocA:
undetectable
2vxaK-4bocA:
undetectable		 2vxaA-4bocA:
4.91
2vxaB-4bocA:
4.91
2vxaK-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.38A 2vxaB-4bocA:
undetectable
2vxaC-4bocA:
undetectable
2vxaG-4bocA:
undetectable		 2vxaB-4bocA:
4.91
2vxaC-4bocA:
4.91
2vxaG-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.37A 2vxaD-4bocA:
undetectable
2vxaF-4bocA:
undetectable
2vxaI-4bocA:
undetectable		 2vxaD-4bocA:
4.91
2vxaF-4bocA:
4.91
2vxaI-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.33A 2vxaD-4bocA:
undetectable
2vxaE-4bocA:
undetectable
2vxaL-4bocA:
undetectable		 2vxaD-4bocA:
4.91
2vxaE-4bocA:
4.91
2vxaL-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 659
GLN A 565
ARG A 516
GLN A 522
 None
 1.38A 2vxaB-4bocA:
undetectable
2vxaG-4bocA:
undetectable
2vxaH-4bocA:
undetectable		 2vxaB-4bocA:
4.91
2vxaG-4bocA:
4.91
2vxaH-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 516
GLN A 522
HIS A 659
GLN A 565
 None
 1.37A 2vxaH-4bocA:
undetectable
2vxaI-4bocA:
undetectable
2vxaJ-4bocA:
undetectable		 2vxaH-4bocA:
4.91
2vxaI-4bocA:
4.91
2vxaJ-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 659
GLN A 565
ARG A 516
GLN A 522
 None
 1.33A 2vxaD-4bocA:
undetectable
2vxaJ-4bocA:
undetectable
2vxaL-4bocA:
undetectable		 2vxaD-4bocA:
4.91
2vxaJ-4bocA:
4.91
2vxaL-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 659
GLN A 565
ARG A 516
GLN A 522
 None
 1.36A 2vxaH-4bocA:
undetectable
2vxaJ-4bocA:
undetectable
2vxaK-4bocA:
undetectable		 2vxaH-4bocA:
4.91
2vxaJ-4bocA:
4.91
2vxaK-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 659
GLN A 565
ARG A 516
GLN A 522
 None
 1.34A 2vxaA-4bocA:
undetectable
2vxaK-4bocA:
undetectable
2vxaL-4bocA:
undetectable		 2vxaA-4bocA:
4.91
2vxaK-4bocA:
4.91
2vxaL-4bocA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 408
LEU A 404
LEU A 526
LEU A 665
ARG A 518
 None
 1.00A 2xn6A-4bocA:
undetectable
2xn6B-4bocA:
undetectable		 2xn6A-4bocA:
14.02
2xn6B-4bocA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 408
LEU A 404
LEU A 526
LEU A 665
ARG A 518
 None
 0.97A 2xn7A-4bocA:
undetectable
2xn7B-4bocA:
undetectable		 2xn7A-4bocA:
14.11
2xn7B-4bocA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 851
VAL A 846
THR A 894
ASP A 870
 None
 0.99A 2zaxA-4bocA:
undetectable		 2zaxA-4bocA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.06A 2zuiA-4bocA:
undetectable		 2zuiA-4bocA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 963
VAL A 965
GLN A 972
PHE A 984
 None
 1.40A 3bjwB-4bocA:
undetectable		 3bjwB-4bocA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 466
CYH A 232
PHE A 470
THR A 236
 None
 0.96A 3bpxA-4bocA:
2.6
3bpxB-4bocA:
3.1		 3bpxA-4bocA:
8.72
3bpxB-4bocA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 GLY A1118
LEU A1127
SER A1126
ILE A1061
SER A1057
ILE A1179
 None
 1.42A 3frqB-4bocA:
undetectable		 3frqB-4bocA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 851
VAL A 846
THR A 894
ASP A 870
 None
 1.05A 3fwgB-4bocA:
undetectable		 3fwgB-4bocA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET A 268
CYH A 319
PRO A 294
 None
 1.26A 3h52C-4bocA:
undetectable		 3h52C-4bocA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 270
ALA A 276
ALA A 242
ALA A 301
ASN A 265
 None
 1.08A 3jb3A-4bocA:
undetectable		 3jb3A-4bocA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH201_1
(PROTEIN S100-A4)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A1010
PHE A1024
PRO A1021
GLY A 983
PHE A 984
 None
 1.46A 3ko0H-4bocA:
undetectable
3ko0I-4bocA:
0.0		 3ko0H-4bocA:
7.15
3ko0I-4bocA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 297
LEU A 234
GLY A 270
ALA A 272
LEU A 280
 None
 1.05A 3n8zB-4bocA:
undetectable		 3n8zB-4bocA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LYS A 853
GLY A 958
ALA A 960
ASP A 954
VAL A 955
 None
 1.21A 3nvkF-4bocA:
2.0
3nvkJ-4bocA:
undetectable		 3nvkF-4bocA:
17.55
3nvkJ-4bocA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 853
ARG A 987
ASP A1151
 None
None
C  R   9 ( 2.8A)
 1.44A 3o7wA-4bocA:
undetectable		 3o7wA-4bocA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 924
PHE A1217
VAL A1222
ALA A 932
HIS A 930
 None
 0.89A 3u9fG-4bocA:
undetectable
3u9fH-4bocA:
undetectable		 3u9fG-4bocA:
10.89
3u9fH-4bocA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.03A 3wrlA-4bocA:
undetectable		 3wrlA-4bocA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASP A 937
THR A1047
VAL A 944
SER A1045
 None
 1.44A 3wxoA-4bocA:
1.5		 3wxoA-4bocA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 575
LEU A 578
GLN A 585
ALA A 448
THR A 508
 None
 0.97A 4fn9A-4bocA:
undetectable		 4fn9A-4bocA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 MET A1064
LEU A1204
ARG A1190
PRO A1110
 None
 1.39A 4kmmB-4bocA:
undetectable		 4kmmB-4bocA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.13A 4l4dA-4bocA:
undetectable		 4l4dA-4bocA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 484
LEU A 487
LEU A 490
ALA A 489
LEU A 434
 None
 1.20A 4ltwA-4bocA:
undetectable		 4ltwA-4bocA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ALA A 580
HIS A 608
PHE A 497
LEU A 606
 None
 1.13A 4lufA-4bocA:
0.0		 4lufA-4bocA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ALA A 580
HIS A 608
PHE A 497
LEU A 606
 None
 1.14A 4luhA-4bocA:
2.7		 4luhA-4bocA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A1172
LEU A1180
ALA A 933
LEU A1127
PHE A1123
 None
 1.40A 4qdcA-4bocA:
undetectable		 4qdcA-4bocA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 297
LEU A 234
GLY A 270
ALA A 272
LEU A 280
 None
 1.07A 5ikqB-4bocA:
undetectable		 5ikqB-4bocA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A1229
TYR A1153
THR A1135
VAL A1222
 None
 1.02A 5wk9A-4bocA:
undetectable		 5wk9A-4bocA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 HIS A1030
TRP A1026
GLU A1027
ARG A 976
 None
 1.26A 6b8kA-4bocA:
undetectable		 6b8kA-4bocA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 854
ARG A 987
ASP A 954
 None
 0.98A 6d8pA-4bocA:
undetectable		 6d8pA-4bocA:
22.69